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SLC12A3

Official Full Name

solute carrier family 12 (sodium/chloride transporters), member 3
Overview

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartters syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SLC12A3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3; NCCT; Na-Cl symporter; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; NaCl electroneutral thiazide-se;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
Myc
DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC12A3-1203H	Recombinant Human SLC12A3 protein, His-tagged	E.coli	His	Glu3~Cys146	Inquiry
Human	SLC12A3-2020H	Recombinant Human SLC12A3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SLC12A3-6672H	Recombinant Human SLC12A3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SLC12A3-2020H-B	Recombinant Human SLC12A3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SLC12A3-1562HFL	Recombinant Full Length Human SLC12A3 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Mouse	SLC12A3-15209M	Recombinant Mouse SLC12A3 Protein	Mammalian Cell	His		Inquiry
Mouse	SLC12A3-8217M	Recombinant Mouse SLC12A3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Slc12a3-5903M	Recombinant Mouse Slc12a3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SLC12A3-8217M-B	Recombinant Mouse SLC12A3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SLC12A3-4132Z	Recombinant Zebrafish SLC12A3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC12A3 Related Research Area

SLC12A3 involved in several pathways and played different roles in them. We selected most pathways SLC12A3 participated on our site, such as Cation-coupled Chloride cotransporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cation-coupled Chloride cotransporters	SLC12A3;SLC12A5B;SLC12A4;SLC12A1;SLC12A7
SLC-mediated transmembrane transport	SLC28A1;SLC5A6B;SLC38A4;PDZD11;SLC1A3B;SLC35D2;SLC22A18;SLC39A14;SLC30A3
Transmembrane transport of small molecules	SLC9A3.2;AQP1A.2;SLC30A5;RHCG2A;ANKH;TRPC4APA;SLC2A10;TRPA1A;SLC35A3B
Transport of inorganic cations/anions and amino acids/oligopeptides	SLC24A5;SLC4A2A;SLC7A10;SLC15A2;SLC26A7;SLC12A7;SLC43A2;SLC6A6A;SLC26A3.1

SLC12A3 has several biochemical functions, for example, cation:chloride symporter activity, enzyme binding, sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A3 itself. We selected most functions SLC12A3 had, and list some proteins which have the same functions with SLC12A3. You can find most of the proteins on our site.

Function	Related Protein
cation:chloride symporter activity	SLC12A10.2;SLC12A2;SLC12A5B;SLC12A10.3;SLC12A3;SLC12A10.1
enzyme binding	C6orf211;BRCA1;ESR2;ATP2A2;HSPA2;DNM2;UGT1A7;CABYR;TP53
sodium ion transmembrane transporter activity	SLC12A10.2;SLC12A10.1;SLC12A10.3;CNNM4;SLC12A3;SLC23A1;ASIC4;SLC12A1;TRAPPC10
sodium:chloride symporter activity	SLC12A1;SLC12A10.1;SLC12A10.3;SLC12A3;SLC12A10.2
symporter activity	SLC24A4;SLC1A7B;SLC5A8L;SLC34A3;SLC16A9;SLC5A8;SLC17A6B;SLC5A11;SLC38A3
transporter activity	AQP3;SLC5A3A;SLC23A1;SLC5A9;AP3B2;CLVS1;HIATL2;GABRA5;ABCA7

SLC12A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A3.

Ywhaz

Renal Markers

Glial Lineage Markers