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SLC22A1

Official Full Name

solute carrier family 22 (organic cation transporter), member 1
Overview

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.
Synonyms

SLC22A1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22 member 1; OCT1; organic cation transporter 1; HOCT1; oct1_cds;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC22A1-6823HF	Recombinant Full Length Human SLC22A1 Protein, GST-tagged	In Vitro Cell Free System	GST	1049 amino acids	Inquiry
Human	SLC22A1-677H	Recombinant Human SLC22A1 Protein	Wheat Germ	N/A		Inquiry
Mouse	SLC22A1-15261M	Recombinant Mouse SLC22A1 Protein	Mammalian Cell	His		Inquiry
Mouse	SLC22A1-8255M-B	Recombinant Mouse SLC22A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SLC22A1-8255M	Recombinant Mouse SLC22A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLC22A1-5451R	Recombinant Rat SLC22A1 Protein	Mammalian Cell	His		Inquiry
Rat	SLC22A1-5110R	Recombinant Rat SLC22A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SLC22A1-5110R-B	Recombinant Rat SLC22A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC22A1 Related Research Area

SLC22A1 involved in several pathways and played different roles in them. We selected most pathways SLC22A1 participated on our site, such as Bile secretion, Choline metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Bile secretion	SULT2A1;ATP1B1;OSTA;ATP1B4;SLC9A3;ABCC2;OSTB;ADCY3;SLC22A1
Choline metabolism in cancer	SP1;PIP5K1B;SLC5A7;PIK3CA;WASF1;DGKQ;MAPK9;GPCPD1;LYPLA1

SLC22A1 has several biochemical functions, for example, acetylcholine transmembrane transporter activity, dopamine transmembrane transporter activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A1 itself. We selected most functions SLC22A1 had, and list some proteins which have the same functions with SLC22A1. You can find most of the proteins on our site.

Function	Related Protein
acetylcholine transmembrane transporter activity
dopamine transmembrane transporter activity	SLC6A3;SLC22A3;SLC22A2;SLC22A1
identical protein binding	ACPP;CLDN3;SERPINA1E;BAX;RUVBL2;FAM108A1;ERBB3;LUC7L;PFKL
monoamine transmembrane transporter activity	SLC6A4;SLC18A1;SLC18A2;SLC22A1;SLC6A3;SLC29A4;SLC6A2
norepinephrine transmembrane transporter activity	SLC22A1;SLC6A2
organic cation transmembrane transporter activity	SLC22A2;SLC7A8;SLC22A14;SLC22A3;SLC22A1
protein homodimerization activity	LCN2;MIXL1;SLC39A13;PSPH;TOX3;PYGB;CAV2;TRIM5;IMPA1
quaternary ammonium group transmembrane transporter activity	SLC22A5;SLC22A1;SLC22A2;SLC22A3
secondary active organic cation transmembrane transporter activity
transmembrane transporter activity	SLC22A23;SLC2A1A;SV2C;SLC2A9L1;SLC17A9B;SLC2A11B;SLC2A15B;SLC2A15A;SV2A
transporter activity	TMEM184A;SLC15A1B;LCN5;RBP2B;ATP5G3;MIP;ATP6AP1;ABCA9;FABP6

SLC22A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A1.

Glial Lineage Markers

Neurotransmitter Transporters