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SLC6A5

  • Official Full Name

    solute carrier family 6 (neurotransmitter transporter, glycine), member 5

  • Overview

    This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane;glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This;protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic;synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by;exaggerated startle responses and neonatal apnea.
  • Synonyms

    SLC6A5; solute carrier family 6 (neurotransmitter transporter, glycine), member 5; NET1; sodium- and chloride-dependent glycine transporter 2; GLYT2; Glycine transporter; Glycine transporter type 2; SC6AC5; SLC6A5 solute carrier family 6 neurotransmitter transporter, glycine member 5; Slc6a9; Sodium and chloride dependent glycine transporter 2; Solute carrier family 6 member 5; Solute carrier family 6 neurotransmitter transporter glycine member 5; OTTHUMP00000231736; GLYT-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • 8His
  • Strep,Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC6A5-118H Recombinant Human SLC6A5 protein, GST-tagged Wheat Germ GST
Human SLC6A5-683H Recombinant Human SLC6A5 Mammalian Cell His
Human SLC6A5-1704HCL Recombinant Human SLC6A5 293 Cell Lysate HEK293 N/A
Human SLC6A5-1207H Recombinant Human SLC6A5 Protein (D2-C797), 8×His-Strep, Flag tagged Insect Cell 8His-Strep,Flag D2-C797
Human SLC6A5-4083H Recombinant Human SLC6A5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SLC6A5-4083H-B Recombinant Human SLC6A5 Protein Pre-coupled Magnetic Beads HEK293
Human SLC6A5-2951H Recombinant Human SLC6A5 protein, His-tagged E.coli His 1-200 aa
Zebrafish SLC6A5-1947Z Recombinant Zebrafish SLC6A5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC6A5 Related Articles

SLC6A5 involved in several pathways and played different roles in them. We selected most pathways SLC6A5 participated on our site, such as Na+/Cl- dependent neurotransmitter transporters, SLC-mediated transmembrane transport, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Na+/Cl- dependent neurotransmitter transportersSLC6A2;SLC6A1B;SLC6A6;SLC6A9;SLC6A18;SLC6A19B;SLC6A11;SLC6A6A;SLC6A12
SLC-mediated transmembrane transportSLC12A5B;SLC13A5A;SLC4A1B;SLC13A5;SLC24A4A;SLC15A4;SLC5A9;SLC39A1;SLC2A15A
Transmembrane transport of small moleculesSLC24A5;ATP1A1A.2;SLC15A2;ABCC2;SLC39A5;TRPC5A;AQP1A.2;SLC41A1;SLC8A2A
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsSLC30A8;RHCGB;SLC39A6;SLC39A3;SLC5A4;SLC6A20A;SLC6A20B;SLC2A10;SLC13A1

SLC6A5 has several biochemical functions, for example, glycine:sodium symporter activity, neurotransmitter:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A5 itself. We selected most functions SLC6A5 had, and list some proteins which have the same functions with SLC6A5. You can find most of the proteins on our site.

Function Related Protein
glycine:sodium symporter activitySLC6A5;SLC6A9
neurotransmitter:sodium symporter activitySLC6A18;SLC6A20A;SLC6A6A;SLC6A11A;SLC6A13;SLC6A16B;SLC6A17;SLC6A9;SLC6A1A

SLC6A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A5.

Sherman, D; Worrell, JW; et al. Optogenetic perturbation of preBotzinger complex inhibitory neurons modulates respiratory pattern. NATURE NEUROSCIENCE 18:408-414(2015).
Arribas-Gonzalez, E; de Juan-Sanz, J; et al. Molecular Basis of the Dominant Negative Effect of a Glycine Transporter 2 Mutation Associated with Hyperekplexia. JOURNAL OF BIOLOGICAL CHEMISTRY 290:2150-2165(2015).
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