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SLC6A18

Official Full Name

solute carrier family 6, member 18
Overview

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids,;and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for;solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 (PubMed 16125675)).
Synonyms

SLC6A18; solute carrier family 6, member 18; solute carrier family 6 (neurotransmitter transporter), member 18; sodium-dependent neutral amino acid transporter B(0)AT3; FLJ31236; Xtrp2; sodium channel-like protein; system B(0) neutral amino acid transport;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	SLC6A18-15498M	Recombinant Mouse SLC6A18 Protein	Mammalian Cell	His	Inquiry
Mouse	SLC6A18-8408M	Recombinant Mouse SLC6A18 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SLC6A18-8408M-B	Recombinant Mouse SLC6A18 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	SLC6A18-5567R	Recombinant Rat SLC6A18 Protein	Mammalian Cell	His	Inquiry
Rat	SLC6A18-5226R	Recombinant Rat SLC6A18 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	SLC6A18-5226R-B	Recombinant Rat SLC6A18 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SLC6A18-6491Z	Recombinant Zebrafish SLC6A18	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC6A18 Related Articles

SLC6A18 involved in several pathways and played different roles in them. We selected most pathways SLC6A18 participated on our site, such as Amino acid transport across the plasma membrane, Na+/Cl- dependent neurotransmitter transporters, SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Amino acid transport across the plasma membrane	SLC43A1A;SLC7A3A;SLC36A2;SLC7A8A;SLC43A2A;SLC1A4;SLC7A6;SLC38A5B;SLC7A3
Na+/Cl- dependent neurotransmitter transporters	SLC6A11;SLC6A15;SLC6A12;SLC6A1A;SLC6A20;SLC6A20A;SLC6A20B;SLC6A1B;SLC6A6
SLC-mediated transmembrane transport	SLC39A2;SLC22A7;SLC3A2B;SLC5A4;SLC2A10;CP;SLC30A8;SLC26A1;APOD
Transmembrane transport of small molecules	CLCNKA;BSND;CUTC;CLCA1;CLCN4;AQP11;SLC15A4;SLC9A8;WNK1
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	CP;SLC6A9;SLC22A12;SLC5A4;SLC2A15B;SLC39A1;SLC6A20A;SLC6A19B;SLC13A3
Transport of inorganic cations/anions and amino acids/oligopeptides	SLC6A6;SLC12A7;SLC6A19A;SLC3A2A;SLC26A3.1;SLC43A1A;SLC26A6L;SLC6A20;SLC24A5

SLC6A18 has several biochemical functions, for example, neurotransmitter:sodium symporter activity, protein binding, symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A18 itself. We selected most functions SLC6A18 had, and list some proteins which have the same functions with SLC6A18. You can find most of the proteins on our site.

Function	Related Protein
neurotransmitter:sodium symporter activity	SLC6A6B;SLC6A4A;SLC6A15;SLC6A12;SLC6A20B;SLC6A7;SLC6A20;SLC6A13;SLC6A8
protein binding	LRRC25;TRAPPC2;SPAG8;NUP62;MED9;ZCCHC8;CCBE1;BUD13;SCFD1
symporter activity	SLC6A19A;SLC6A4B;SLC6A13;MFSD2A;SLC38A4;SLC24A5;SLC17A4;SLC10A7;SLC16A14
transporter activity	CRABP1;FLVCR1;SLC15A1B;ATP5B;SLC5A12;CRABP2;CHP;ABCA7;SLCO4C1

SLC6A18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A18 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A18.

Wade, KH; Forouhi, NG; et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. AMERICAN JOURNAL OF CLINICAL NUTRITION 101:202-209(2015).

Grochans, E; Grzywacz, A; et al. The 5HTT and MAO-A polymorphisms associate with depressive mood and climacteric symptoms in postmenopausal women. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 45:125-130(2013).