SLC22A18

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described.

SLC22A18; solute carrier family 22, member 18; BWSCR1A, IMPT1, ORCTL2, SLC22A1L, solute carrier family 22 (organic cation transporter), member 1 like; solute carrier family 22 member 18; BWR1A; ITM; TSSC5; IMPT1; OTTMUSP00000030800; Beckwith Wiedemann syndrome chromosomal region 1 candidate gene A protein; BWSCR1A; DKFZp667A184; Efflux transporter like protein; HET; Imprinted multi membrane spanning polyspecific transporter related protein 1; MGC94186; ORCTL 2; ORCTL2; Organic cation transporter like protein 2; OTTMUSP00000030799; p45 Beckwith Wiedemann region 1 A; p45 BWR1A; SLC22A1L; Solute carrier family 22 member 1 like; TSSC5v; Tumor suppressing STF cDNA 5 protein; Tumor suppressing subchromosomal transferable fragment candidate gene 5 protein; ORCTL-2; OTTHUMP00000011731; OTTHUMP00000011732; OTTHUMP00000011733; OTTHUMP00000012598; efflux transporter-like protein; p45 Beckwith-Wiedemann region 1A; organic cation transporter-like 2; p45-Beckwith-Wiedemann region 1 A; tumor-suppressing STF cDNA 5 protein; organic cation transporter-like protein 2; Beckwith-Wiedemann syndrome chromosome region 1, candidate A; beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; imprinted multi-membrane spanning polyspecific transporter-related protein 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein; p45-BWR1A;