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SLC6A11

  • Official Full Name

    solute carrier family 6 (neurotransmitter transporter, GABA), member 11

  • Overview

    Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the;uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters,;such as SLC6A11 (Borden et al., 1994 (PubMed 7874447)).
  • Synonyms

    SLC6A11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11; sodium- and chloride-dependent GABA transporter 3; GAT-3; GABA transporter GAT-3; solute carrier family 6 member 11; Gat3; Gabt4;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC6A11-666H Recombinant Human SLC6A11 Protein, GST-tagged Wheat Germ GST 1-208 aa
Human SLC6A11-6812HF Recombinant Full Length Human SLC6A11 Protein, GST-tagged In Vitro Cell Free System GST 208 amino acids
Mouse SLC6A11-15492M Recombinant Mouse SLC6A11 Protein Mammalian Cell His
Mouse SLC6A11-8404M Recombinant Mouse SLC6A11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SLC6A11-8404M-B Recombinant Mouse SLC6A11 Protein Pre-coupled Magnetic Beads HEK293
Rat SLC6A11-5562R Recombinant Rat SLC6A11 Protein Mammalian Cell His
Rat SLC6A11-5221R Recombinant Rat SLC6A11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC6A11-5221R-B Recombinant Rat SLC6A11 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SLC6A11-4302R Recombinant Rhesus monkey SLC6A11 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLC6A11-4118R Recombinant Rhesus Macaque SLC6A11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SLC6A11-4118R-B Recombinant Rhesus Macaque SLC6A11 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC6A11 Related Articles

SLC6A11 involved in several pathways and played different roles in them. We selected most pathways SLC6A11 participated on our site, such as GABA synthesis, release, reuptake and degradation, Na+/Cl- dependent neurotransmitter transporters, Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GABA synthesis, release, reuptake and degradationSLC6A1A;ABAT;SNAP25B;RAB3AB;CCDC167;SLC6A12;SYT1A;SLC6A11;SLC6A1B
Na+/Cl- dependent neurotransmitter transportersSLC6A20B;SLC6A12;SLC6A7;SLC6A15;SLC6A20;SLC6A20A;SLC6A1B;SLC6A18;SLC6A9
Neuronal SystemKCNA1;KCNJ1A.4;PPFIA4;CACFD1;SNAP25B;KCNG3;KCNH5A;KCNJ11;KCNC1
Neurotransmitter Release CycleARL6IP5A;SLC1A2A;CPLX1;SLC6A1B;SYT1A;Apba1;SLC17A7A;SLC18A3A;LIN7C
Reuptake of GABASLC6A1B;SLC6A1A;SLC6A11
SLC-mediated transmembrane transportSLC3A2B;SLC16A8;SLC2A13;SLC22A18;SLC13A1;SLC39A1;SLC28A2;SLC26A7;SLC39A14
Transmembrane transport of small moleculesSLC26A7;SLC12A1;ATP10A;SLC29A4;SLC43A2;AQP8A.1;SLC1A2A;SLC9A10;PIP
Transmission across Chemical SynapsesARL6IP5B;LIN7B;PPFIA1;SLC6A1A;ARL6IP5A;GRIP1;CACNG2B;PICK1;SLC1A7A

SLC6A11 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity, neurotransmitter binding, neurotransmitter:sodium symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A11 itself. We selected most functions SLC6A11 had, and list some proteins which have the same functions with SLC6A11. You can find most of the proteins on our site.

Function Related Protein
gamma-aminobutyric acid:sodium symporter activitySLC6A12;SLC6A11A;SLC6A1;SLC6A13L;SLC6A13;SLC6A1A;SLC6A1B;SLC6A11
neurotransmitter bindingGRIN3B;GRIN1;NIPSNAP1;SLC6A13;SLC6A11;GRIN2A
neurotransmitter:sodium symporter activitySLC6A12;SLC6A20A;SLC6A18;SLC6A13;SLC6A8;SLC6A1B;SLC6A16B;SLC6A11A;SLC6A6
symporter activitySLC6A1A;SLC24A4;SLC22A5;SLC5A8;MFSD2AA;SLC16A7;SLC17A6;SLC34A2;SLC16A6

SLC6A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A11.

Dikow, N; Maas, B; et al. 3p25.3 Microdeletion of GABA Transporters SLC6A1 and SLC6A11 Results in Intellectual Disability, Epilepsy and Stereotypic Behavior. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3061-3068(2014).
Ramirez, O; Olalde, I; et al. Analysis of structural diversity in wolf-like canids reveals post-domestication variants. BMC GENOMICS 15:-(2014).
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