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SLC2A4

  • Official Full Name

    solute carrier family 2 (facilitated glucose transporter), member 4

  • Overview

    This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
  • Synonyms

    SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; GLUT4; solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; OTTHUMP00000128376; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Human
  • Mouse
  • Rat
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC2A4-038H Active Recombinant Human SLC2A4 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human SLC2A4-112H Recombinant Human SLC2A4 protein, GST-tagged Wheat Germ GST
Human SLC2A4-2746H Recombinant Human SLC2A4, GST-tagged E.coli GST 228-292aa
Human SLC2A4-113H Recombinant Human SLC2A4 protein, GST-tagged Wheat Germ GST
Human SLC2A4-1644H Recombinant Human SLC2A4 protein, His & GST-tagged E.coli His/GST Arg228~Val292 (Accession # P14672)
Human SLC2A4-2171H Recombinant Human SLC2A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SLC2A4-805HFL Recombinant Full Length Human SLC2A4 Protein, C-Flag-tagged Mammalian cells Flag
Human SLC2A4-2658H Recombinant Human SLC2A4 Protein (Cys223-Leu278), N-SUMO tagged E.coli N-SUMO Cys223-Leu278
Human SLC2A4-632HF Recombinant Full Length Human SLC2A4 Protein, GST-tagged In Vitro Cell Free System GST 509 amino acids
Human SLC2A4-2029H Recombinant Human SLC2A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SLC2A4-2657H Recombinant Human SLC2A4 Protein (Cys223-Leu287), SUMO tagged E.coli SUMO Cys223-Leu287
Human SLC2A4-2029H-B Recombinant Human SLC2A4 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC2A4-15365M Recombinant Mouse SLC2A4 Protein Mammalian Cell His
Mouse SLC2A4-8314M Recombinant Mouse SLC2A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Slc2a4-5920M Recombinant Mouse Slc2a4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Slc2a4-2695M Recombinant Mouse Slc2a4 Protein, His&GST-tagged E.coli N-His&GST Arg228-Val292
Mouse SLC2A4-8314M-B Recombinant Mouse SLC2A4 Protein Pre-coupled Magnetic Beads HEK293
Rat SLC2A4-5498R Recombinant Rat SLC2A4 Protein Mammalian Cell His
Rat SLC2A4-5157R Recombinant Rat SLC2A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SLC2A4-5157R-B Recombinant Rat SLC2A4 Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL28664CF Recombinant Full Length Dog Solute Carrier Family 2, Facilitated Glucose Transporter Member 4(Slc2A4) Protein, His-Tagged E.coli expression system His Full Length (1-162)
Sus scrofa (Pig) RFL9141SF Recombinant Full Length Pig Solute Carrier Family 2, Facilitated Glucose Transporter Member 4(Slc2A4) Protein, His-Tagged E.coli expression system His Full Length (1-174)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLC2A4 Related Research Area

SLC2A4 involved in several pathways and played different roles in them. We selected most pathways SLC2A4 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC2A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayGADD45AA;FASLG;KLF2;PRKAA2;PLK2;G6PCA.1;IL7R;CDKN1BB;BCL6A
AMPK signaling pathwayEEF2K;PFKP;ACACA;ADIPOR1;G6PC;ADIPOQ;STRADB;CREB5;GYS1
Insulin signaling pathwayFLOT2A;INPPL1A;PPP1CAA;INSRA;PRKACA;PRKAR1AB;PPP1R3C;GRB2A;PRKACBB
Adipocytokine signaling pathwayRELA;PRKAA2;ADIPOQ;RXRA;PRKAG3;MAPK8A;LEPR;RXRBA;CPT1A
Type II diabetes mellitusHK1;INS1;INSR;CACNA1G;PIK3R5;HK3;SOCS1;MAPK1;PIK3R1
Insulin resistanceINSRA;PPARAB;SLC2A1;PTPN11A;AKT1;CREB3L3A;INSR;G6PCA.1;RPS6KA3B

SLC2A4 has several biochemical functions, for example, D-glucose transmembrane transporter activity, glucose transmembrane transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC2A4 itself. We selected most functions SLC2A4 had, and list some proteins which have the same functions with SLC2A4. You can find most of the proteins on our site.

Function Related Protein
D-glucose transmembrane transporter activitySLC2A4;SLC2A2;SLC2A1;SLC2A13B
glucose transmembrane transporter activitySLC2A8;SLC2A3A;SLC2A9L1;SLC2A15A;SLC2A3;SLC2A11B;SLC2A6;SLC2A15B;SLC2A11L
protein bindingRAB2B;GIPC1;TEAD4;TRAF3IP3;MIS18A;OFD1;PRDX6;VAV1;MAP3K2

SLC2A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC2A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC2A4.

DAXX; tax

  • Q&As
  • Reviews

Q&As (5)

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How does SLC2A4 protein relate to heart health? 02/09/2023

SLC2A4 dysfunction may contribute to impaired glucose metabolism in the heart, potentially impacting cardiac function and increasing the risk of heart disease.

How does exercise affect SLC2A4 protein expression and function? 11/11/2022

Regular exercise can enhance SLC2A4 expression and translocation to the cell membrane, improving glucose uptake and insulin sensitivity.

Can SLC2A4 protein be targeted for therapeutic interventions? 05/07/2020

Yes, SLC2A4 is a potential target for developing drugs to improve glucose uptake and insulin sensitivity in diabetes.

What are the potential implications of SLC2A4 protein in cancer? 08/21/2017

Some studies suggest that SLC2A4 may play a role in the metabolism of cancer cells, and its expression levels could be linked to cancer progression and prognosis.

Can genetic variations in the SLC2A4 gene influence individual response to antidiabetic medications? 02/18/2017

Yes, genetic variations in SLC2A4 may impact how individuals respond to certain antidiabetic medications, such as insulin sensitizers.

Customer Reviews (3)

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Reviews
02/08/2023

    The SLC2A4 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).

    11/13/2022

      Its purity and reliability ensure reliable and reproducible results in a variety of research applications.

      07/29/2019

        The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.

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