SLC2A4
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Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 4
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Overview
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). -
Synonyms
SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; GLUT4; solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; OTTHUMP00000128376; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Canis lupus familiaris (Dog) (Canis familiaris)
- Human
- Mouse
- Rat
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- SLC2A4 Related Research Area
SLC2A4 involved in several pathways and played different roles in them. We selected most pathways SLC2A4 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC2A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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FoxO signaling pathway | GADD45AA;FASLG;KLF2;PRKAA2;PLK2;G6PCA.1;IL7R;CDKN1BB;BCL6A |
AMPK signaling pathway | EEF2K;PFKP;ACACA;ADIPOR1;G6PC;ADIPOQ;STRADB;CREB5;GYS1 |
Insulin signaling pathway | FLOT2A;INPPL1A;PPP1CAA;INSRA;PRKACA;PRKAR1AB;PPP1R3C;GRB2A;PRKACBB |
Adipocytokine signaling pathway | RELA;PRKAA2;ADIPOQ;RXRA;PRKAG3;MAPK8A;LEPR;RXRBA;CPT1A |
Type II diabetes mellitus | HK1;INS1;INSR;CACNA1G;PIK3R5;HK3;SOCS1;MAPK1;PIK3R1 |
Insulin resistance | INSRA;PPARAB;SLC2A1;PTPN11A;AKT1;CREB3L3A;INSR;G6PCA.1;RPS6KA3B |
SLC2A4 has several biochemical functions, for example, D-glucose transmembrane transporter activity, glucose transmembrane transporter activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC2A4 itself. We selected most functions SLC2A4 had, and list some proteins which have the same functions with SLC2A4. You can find most of the proteins on our site.
Function | Related Protein |
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D-glucose transmembrane transporter activity | SLC2A4;SLC2A2;SLC2A1;SLC2A13B |
glucose transmembrane transporter activity | SLC2A8;SLC2A3A;SLC2A9L1;SLC2A15A;SLC2A3;SLC2A11B;SLC2A6;SLC2A15B;SLC2A11L |
protein binding | RAB2B;GIPC1;TEAD4;TRAF3IP3;MIS18A;OFD1;PRDX6;VAV1;MAP3K2 |
SLC2A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC2A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC2A4.
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- Q&As
- Reviews
Q&As (5)
Ask a questionSLC2A4 dysfunction may contribute to impaired glucose metabolism in the heart, potentially impacting cardiac function and increasing the risk of heart disease.
Regular exercise can enhance SLC2A4 expression and translocation to the cell membrane, improving glucose uptake and insulin sensitivity.
Yes, SLC2A4 is a potential target for developing drugs to improve glucose uptake and insulin sensitivity in diabetes.
Some studies suggest that SLC2A4 may play a role in the metabolism of cancer cells, and its expression levels could be linked to cancer progression and prognosis.
Yes, genetic variations in SLC2A4 may impact how individuals respond to certain antidiabetic medications, such as insulin sensitizers.
Customer Reviews (3)
Write a reviewThe SLC2A4 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).
Its purity and reliability ensure reliable and reproducible results in a variety of research applications.
The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.
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