Recombinant Human SLC4A4, His-tagged

• Cat.No.: SLC4A4-31419TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-424 of human SLC4A4 fused to His tag at N-terminus; 460 amino acids, 51.5 kDa.

Specification

• Description: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 i
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 0.5mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGE EDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVD HQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKL PRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIAGIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ
• Sequence Similarities: Belongs to the anion exchanger (TC 2.A.31) family.

Gene Information

• Gene Name: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 [ Homo sapiens ]
• Official Symbol: SLC4A4
• Synonyms: SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; SLC4A5; electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; NBC1; NBC2; pNBC
• Gene ID: 8671
• mRNA Refseq: NM_001098484
• Protein Refseq: NP_001091954
• MIM: 603345
• Uniprot ID: Q9Y6R1
• Chromosome Location: 4q21
• Pathway: Bicarbonate transporters, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem
• Function: anion transmembrane transporter activity; inorganic anion exchanger activity; protein binding; sodium:bicarbonate symporter activity; symporter activity