"SLC4A4" Related Products

Recombinant Human SLC4A4, His-tagged

Cat.No.: SLC4A4-31419TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-424 of human SLC4A4 fused to His tag at N-terminus; 460 amino acids, 51.5 kDa.
Description: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Conjugation: HIS
Source: E. coli
Tissue specificity: Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 i
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 0.5mM DTT, 0.1mM PMSF, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGE EDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVD HQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKL PRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIAGIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ
Sequence Similarities: Belongs to the anion exchanger (TC 2.A.31) family.
Gene Name: SLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 4 [ Homo sapiens ]
Official Symbol: SLC4A4
Synonyms: SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; SLC4A5; electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; NBC1; NBC2; pNBC;
Gene ID: 8671
mRNA Refseq: NM_001098484
Protein Refseq: NP_001091954
MIM: 603345
Uniprot ID: Q9Y6R1
Chromosome Location: 4q21
Pathway: Bicarbonate transporters, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem;
Function: anion transmembrane transporter activity; inorganic anion exchanger activity; protein binding; sodium:bicarbonate symporter activity; symporter activity;

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