Mast Cell
About Mast Cell
Mast cells are a type of white blood cell that is involved in the immune response and play a crucial role in allergic reactions. They are found in connective tissues throughout the body, particularly in areas that are in contact with the external environment, such as the skin, respiratory tract, and digestive system.
Mast cells are specialized immune cells that play a vital role in allergic reactions, immune defense against pathogens, and tissue repair. Understanding the complex functions of mast cells is crucial for developing treatments for allergies, immune disorders, and inflammatory conditions.
Physiologic Functions of Mast Cell
Allergic Reactions: Mast cells are well-known for their role in allergic reactions. When exposed to an allergen, such as pollen, dust mites, or certain foods, mast cells release chemical mediators, including histamine, leukotrienes, and prostaglandins. These mediators cause the symptoms associated with allergies, such as itching, swelling, redness, and respiratory difficulties.
Immune Response: Mast cells are an integral part of the body's immune system. They express receptors on their surface that can recognize and respond to various pathogens, including bacteria, viruses, and parasites. When activated, mast cells release immune mediators that help recruit and activate other immune cells, such as neutrophils and eosinophils, to the site of infection, enhancing the immune response against the invading pathogens.
Inflammation: Mast cells play a crucial role in the initiation and regulation of inflammation. Upon activation, mast cells release inflammatory mediators, such as histamine, cytokines, chemokines, and growth factors. These mediators help to recruit immune cells to the site of injury or infection, promote blood vessel dilation, and increase vascular permeability, all of which are essential components of the inflammatory response.
Tissue Repair and Remodeling: Mast cells are involved in tissue repair and remodeling processes. They release factors that promote the growth of blood vessels (angiogenesis) and stimulate the migration and proliferation of fibroblasts, which are cells responsible for collagen production and wound healing. Mast cells are also involved in tissue remodeling associated with conditions like asthma and fibrosis.
Defense against Parasites: Mast cells play a critical role in defense against parasitic infections. When activated by parasites, mast cells release mediators that help eliminate the parasites and recruit other immune cells, such as eosinophils, which are effective in fighting parasitic infections.
Neuroimmune Interactions: Mast cells have a close relationship with the nervous system. They interact with nerve fibers and release mediators that can modulate nerve activity, contributing to neuroimmune communication and regulating various physiological processes.
Fig.2 Potential interactions between MCs and airway immune cells. (Bradding P, et al., 2016)
Available Resources for Mast Cell
At Creative BioMart, we are dedicated to providing a wide selection of products related to mast cells, including recombinant proteins and more. Our main focus is to meet the specific needs of researchers in academia and the biopharmaceutical industry. We understand the unique requirements of these sectors, and therefore, we offer personalized services tailored to their specific needs.
In addition to our diverse product range and customized services, we are proud to offer a comprehensive range of resources covering all aspects of mast cells. Our resources provide detailed information on involved pathways, protein functions, interacting proteins, relevant articles, comprehensive research area overviews, and in-depth discussions on various related topics.
Our commitment is to support your research and development efforts in the dynamic field of mast cells. We encourage you to thoroughly explore our product portfolio, take advantage of our customization services, and leverage the wealth of detailed resources we provide to advance your scientific pursuits.
Fig.3 Mechanisms of mast cell signaling in anaphylaxis - Signaling pathways that lead from activated KIT and aggregated FcϵRI to mast cell responses. (Metcalfe DD, et al., 2009)
Our Featured Products
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References:
- Bradding P, Arthur G. Mast cells in asthma--state of the art. Clin Exp Allergy. 2016;46(2):194-263. doi:10.1111/cea.12675
- Walker ME, Hatfield JK, Brown MA. New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta. 2012 Jan;1822(1):57-65. doi: 10.1016/j.bbadis.2011.02.009.
- Metcalfe DD, Peavy RD, Gilfillan AM. Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol. 2009 Oct;124(4):639-46; quiz 647-8. doi: 10.1016/j.jaci.2009.08.035.
