What is PPP2R2A Protein

PPP2R2A is a protein encoding gene whose full name is protein phosphatase 2 regulatory subunit B Alpha. The PPP2R2A protein belongs to a family of proteins that are integral to various functional processes within cells and have significant roles in sending signals that control cell proliferation, differentiation, migration, and apoptosis.

(Lenaerts, L. et al. 2021)

Function of PPP2R2A Protein

The PPP2R2A protein is essential for cellular function as it is a significant part of the protein phosphatase 2 (PP2A), a major Ser/Thr phosphatase. PP2A is a heterotrimeric holoenzyme consisting of a structural subunit A, a regulatory subunit B, and a catalytic subunit C. PPP2R2A encodes a member of the B family, which contributes to the functional diversity of PP2A.

The holoenzyme of PP2A, and therefore the PPP2R2A protein, acts as a modulator of many biological processes. It has a pivotal role in regulating cell development, growth, division, signal transduction and transcription processes, response to stress, metabolism, and apoptosis.

PPP2R2A Protein Related Signal Pathway

The variety of intracellular processes regulated by the PPP2R2A protein is due to its reciprocal relationship with numerous metabolic and signaling pathways. One of these signaling pathways is the PTEN/PI3K/AKT/mTOR pathway that plays a critical role in cell cycle progression, promoting cell growth and survival. PPP2R2A as part of PP2A counteracts the activity of the AKT protein, leading to decreased cell survival and proliferation.

Another noteworthy pathway is the MAPK signaling pathway. In this pathway, PP2A acts as a negative regulator by dephosphorylating MAPK, ultimately disrupting the continuation of signals that are critical for mitogenic stimuli, differentiation, survival, and apoptosis.

PPP2R2A Protein Related Diseases

Given its vital role in various cell biological processes, dysregulation of PPP2R2A can contribute to the development of numerous diseases such as cancer. Mutations that inactivate PPP2R2A have been detected in various types of cancer such as breast and ovarian cancers, gliomas and melanomas. These mutations can lead to uncontrolled cell proliferation, hence fostering tumor development and growth.

Interestingly, late-onset Alzheimer's disease has also been linked to PPP2R2A, although the mechanism is not yet fully understood. Researchers have found an association between specific genetic variations in PPP2R2A and Alzheimer's disease risk, highlighting the importance of this protein in maintaining normal neurological function.

PPP2R2A Protein's Applications in Biomedical

Due to its roles in maintaining cell function and its links to various diseases, PPP2R2A protein has significant implications in biomedical science. One of the primary applications is in the field of oncology. By understanding the exact molecular mechanisms by which PPP2R2C contributes to tumor genesis and progression, researchers can develop targeted therapeutic strategies that can reactivate PP2A or inhibit the pathways it negatively regulates.

Moreover, the potential role of PPP2R2A in neurodegenerative disorders represents another field for further investigation. Therapies that can modulate PPP2R2A to reduce the risk or slow the progress of diseases such as Alzheimer's are of prime interest.

In conclusion, the PPP2R2A protein plays an indispensable role in various cell biological processes, maintaining growth, survival, and apoptosis. Its relationship with diverse signal pathways highlights the complex web of cellular activities. Understanding the PPP2R2A protein's role can better illuminate the mechanisms of multiple diseases, providing the foundation necessary for any future treatment interventions.

Our Featured Products

Cat.No.	Product Name	Species	Source (Host)	Tag
PPP2R2A-1916H	Recombinant Human PPP2R2A, His-tagged	Human	E.coli	His
PPP2R2A-7032M	Recombinant Mouse PPP2R2A Protein, His (Fc)-Avi-tagged	Mouse	HEK293	His (Fc)-Avi
PPP2R2A-4634R	Recombinant Rat PPP2R2A Protein	Rat	Mammalian Cell	His
PPP2R2A-807C	Recombinant Cynomolgus PPP2R2A Protein, His-tagged	Cynomolgus	Mammalian Cell	His
PPP2R2A-2577C	Recombinant Chicken PPP2R2A	Chicken	Mammalian Cell	His

Reference

• Lenaerts, L., Reynhout, S., Verbinnen, I., Laumonnier, F., Toutain, A., Hoorne, Y., Joss, S., Chassevent, A. K., Loeys, B., Joset, P., Steindl, K., Rauch, A., Mehta, S. G., Chung, W. K., Devriendt, K., Holder, S. E., Jewett, T., Baldwin, L. M., Wilson, W. G., . . .  Janssens, V. (2021). The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction. Genetics in Medicine, 23(2), 352-362. https://doi.org/10.1038/s41436-020-00981-2