A1CF Protein, APOBEC1 complementation factor

A1CF

Home / Products / A1CF

A1CF

Official Full Name APOBEC1 complementation factor
Background Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
Synonyms A1CF; APOBEC1 complementation factor; ACF; ACF64; ACF65; APOBEC1CF; ASP; apo-B RNA editing protein; APOBEC-1 stimulating protein; apobec-1 complementation factor (ACF) (ASP); RP11-564C4.2; MGC163391;
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human A1CF-641H Recombinant Human A1CF Protein, His-tagged E.coli His
    Human A1CF-9165HCL Recombinant Human A1CF 293 Cell Lysate HEK293 N/A
    Rat A1CF-376R Recombinant Rat A1CF Protein Mammalian Cell His

    A1CF involved in several pathways and played different roles in them. We selected most pathways A1CF participated on our site, such as Formation of the Editosome, Gene Expression, mRNA Editing, which may be useful for your reference. Also, other proteins which involved in the same pathway with A1CF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Formation of the Editosome APOBEC1; A1CF
    Gene Expression CSTF2; CLP1; PTBP1A; ANP32A; COBRA1; SNAPC3; TAF1D; PRDM7; POLR3H; TYW1
    mRNA Editing APOBEC1; ADARB1A; A1CF; ADARB1
    mRNA Editing: C to U Conversion APOBEC1; A1CF

    A1CF has several biochemical functions, for example, RNA binding, NOT double-stranded RNA binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A1CF itself. We selected most functions A1CF had, and list some proteins which have the same functions with A1CF. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding DDX53; RCL1; MOV10B.2; CWC15; THOC6; RPS16; RDBP; HNRNPL; RNMTL1B; RPS9
    NOT double-stranded RNA binding A1CF
    nucleotide binding PUF60A; HNRNPL; CNOT4; HSPA4L; EEF2A.2; RBM41; POLR2D; RMI1; DCLK2; SRSF2
    protein binding HSF1; SCUBE3; WEE1; LRRC29; SAFB; FAM81B; NUP85; GUCY1A3; ADORA2A; PADI4
    single-stranded RNA binding LONP1; IFIH1; AGO3; CBX7; HNRNPF; IFIT5; LSM14A; NXF1; HMGB1; AGO1

    A1CF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A1CF here. Most of them are supplied by our site. Hope this information will be useful for your research of A1CF.

    REL; TRAF1; FHL3; uvrB; ssrna_au

    Nonaka, T; Doi, T; et al. Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:2747-2751(2009).
    Conticello, SG; et al. The AID/APOBEC family of nucleic acid mutators. GENOME BIOLOGY 9:-(2008).

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy