• Official Full Name
  • APOBEC1 complementation factor
  • Background
  • Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
  • Synonyms
  • A1CF; APOBEC1 complementation factor; ACF; ACF64; ACF65; APOBEC1CF; ASP; apo-B RNA editing protein; APOBEC-1 stimulating protein; apobec-1 complementation factor (ACF) (ASP); RP11-564C4.2; MGC163391;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human A1CF Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat A1CF Protein
Source (Host):Species:Human
Product nameRecombinant Human A1CF 293 Cell Lysate

Involved Pathway

A1CF involved in several pathways and played different roles in them. We selected most pathways A1CF participated on our site, such as Formation of the Editosome, Gene Expression, mRNA Editing, which may be useful for your reference. Also, other proteins which involved in the same pathway with A1CF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Formation of the Editosome
Gene Expression
mRNA Editing
mRNA Editing: C to U Conversion

Protein Function

A1CF has several biochemical functions, for example, RNA binding, NOT double-stranded RNA binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by A1CF itself. We selected most functions A1CF had, and list some proteins which have the same functions with A1CF. You can find most of the proteins on our site.
Related Protein
Function RNA binding
Related Protein LSM5; METTL3; PUSL1; DDX19B; RPS25; OOEP; NOL9; HNRNPL2; EIF3BA; DDX3X
Function NOT double-stranded RNA binding
Related Protein A1CF
Function nucleotide binding
Related Protein MCM3L; IFT22; GC3; Adcy4; PRKACAA; CPSF7; RHOT1A; RBM12B; ATP1A1A.3; SEPT7A
Function protein binding
Related Protein BLM; ZC3H10; PI4KB; RPL22; CEP72; ALDH3A1; DNMT1; TBC1D17; PLOD3; RSPH1
Function single-stranded RNA binding
Related Protein JMJD6; LONP1; SNRPC; ZFP36; DDX58; IFIH1; CNBP; ANXA1; AGO3; POLR2GL

Interacting Protein

A1CF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with A1CF here. Most of them are supplied by our site. Hope this information will be useful for your research of A1CF.
REL; TRAF1; FHL3; uvrB; ssrna_au

A1CF Related Articles

Nonaka, T; Doi, T; et al. Carboxy-terminal domain of AID required for its mRNA complex formation in vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:2747-2751(2009).
Conticello, SG; et al. The AID/APOBEC family of nucleic acid mutators. GENOME BIOLOGY 9:-(2008).