actn2
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  • Official Full Name
  • actinin, alpha 2
  • Background
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
  • Synonyms
  • ACTN2; actinin, alpha 2; CMD1AA; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle;
Cat.#:ACTN2-1023HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACTN2 Protein, MYC/DDK-tagged
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Cat.#:ACTN2-31382THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTN2, His-tagged
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Cat.#:ACTN2-361HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTN2 protein, His/MBP-tagged
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Cat.#:Actn2-539MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Actn2 Protein, His-tagged
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Cat.#:ACTN2-6875CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTN2
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Involved Pathway

ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion, Adherens junction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
PDGFAA; GRB2B; PAK2A; MET; XIAP; DOCK1; ACTN2; IBSP; PTENB; MAP2K1
Adherens junction
PVRL3B; CDC42L2; SRC; WASF3B; ACTN3; PTPRM; VCL; PTBP3; BAIAP2A; SSX2IP
Tight junction
CLDN15; INADL; CLDNE; SHROOM2; CLDNB; PPP2R2A; RHOAC; PRKCG; PARD6A; MYL9A
Leukocyte transendothelial migration
ICAM1; PECAM1; GNAI3; CLDN7; MYL5; NIPAL1; PRKCG; ACTN4; PXN; THY1
Regulation of actin cytoskeleton
PIK3CA; MYLPFB; PIK3R3B; TMSB; ARHGAP35; ITGA3B; SCINLA; SSH3; ITGA8; PPP1R12A
Amoebiasis
COL4A5; CXCL8; SERPINB2; IL-8; COL4A6; RELA; TGFB3; COL4A3; SERPINB6B; RAB7B
Viral carcinogenesis
HDAC7A; CCND2; GSN; HIST1H2BD; DLG1; STAT5A; CCND1; HDAC2; YWHAG; HLA-G
Systemic lupus erythematosus
HIST1H4I; HIST1H2BJ; HIST2H3C2; HLA-DRB3; HLA-DPA1; HIST1H2AB; H2AFJ; C1S; HIST1H2AK; HLA-DRA
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ACTB; DES; CACNG7; SGCG; CACNA2D4; ITGA2; DAG1; RYR2; LMNA; GJA1

Protein Function

ACTN2 has several biochemical functions, for example, FATZ binding, LIM domain binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.
Function
Related Protein
Function FATZ binding
Related Protein MYOZ1; ACTN2; TCAP
Function LIM domain binding
Related Protein LDB1A; LDB2; LDB2B; RPH3AL; LDB2A; LDB1B; ACTN2; LDB1; RIPK2; CSRP2BP
Function actin filament binding
Related Protein CORO1C; MTSS1; SHROOM3; EGFR; MYO3A; TTN; FSCN2A; PANX1; MYH9A; WIPF2
Function calcium ion binding
Related Protein CLSTN3; PCDH2AA1; MMP25; F9; CAPSLB; NCALDA; TC2N; S100V2; PCDH1G22; TMPRSS6
Function cytoskeletal protein binding
Related Protein FABP3; PTPN3; DES; ANXA2B; MYLIP; MSNB; MSNA; PKD2; ANXA2; EZRA
Function identical protein binding
Related Protein CTSC; PARP1; NLRC4; BRAP; USP2; COL7A1; E2F7; GOT2A; PSME3; DYNLRB1
Function integrin binding
Related Protein CXADR; CIB2; COL4A3; CYR61L1; SRC; ICAM4; EGFL6; NF2; L1CAM; ANGPTL3
Function ion channel binding
Related Protein KCNQ1; CIB1; RIMS3; KCNIP2; S100A10; LRRK2; KCNIP1; NOS1; USP10; ACTN2
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein RPH3A; TIRAP; KCNJ2; MAPKAP1; KCNJ1; CCDC167; STXBP6L; PFN1; ASAP1; SLC9A1
Function protein binding
Related Protein UBASH3A; RHOA; DAP3; FTH1; ERAL1; DUSP15; SLAMF7; RNF7; COL6A2; CTNNA3
Function protein dimerization activity
Related Protein NPAS4A; NHLH1; PEX3; STRA8; MESPAB; NEUROG2; ATOH7; NPAS4; AIFM1; TFEB
Function protein domain specific binding
Related Protein YWHABB; BASP1; YWHAZ; KCNN2; SLC34A2; TRIM11; SNCA; CASKIN1; CAPG; SERPINB1A
Function protein homodimerization activity
Related Protein PDK2; PVRL3; MYOM1; LGALS1; LCN2; TYMS; TFAP4; PLEK; PTS; ADRA2A
Function structural constituent of muscle
Related Protein MYH11; MYBPC3; MYOT; CAPN3; MYL2; PDLIM3; MYBPC2; MYOM1; SMTN; ANKRD2
Function thyroid hormone receptor coactivator activity
Related Protein ACTN2; NCOA2; MED16; MED1
Function titin Z domain binding
Related Protein ACTN2; TCAP
Function titin binding
Related Protein ANKRD23; TRIM63; MYBPC3; CAPN3; CALM1; ANKRD1; SLC14A2; ACTN2; OBSCN; CALM

Interacting Protein

ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.
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