ACTN2
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Official Full Name
actinin, alpha 2 -
Overview
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] -
Synonyms
ACTN2;actinin, alpha 2;CMD1AA;alpha-actinin-2;F-actin cross-linking protein;alpha-actinin skeletal muscle
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- His
- MBP
- DDK
- Myc
- GST
- Avi
- Fc
- Flag
Involved Pathway
ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion,Adherens junction,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | ARHGAP35,PIK3R1,CLDN17,ITGB2L,ITGAL,PRKCA,CLDN15,ACTN4,RAC1,CLDN3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSC2,ATP2A2,ACTN4,CACNB4,ITGA6,DAG1,ITGA8,CACNA2D3,PKP2,ITGA7 |
| Tight junction | RRAS2,PRKCE,MYH11A,PRKCI,GNAIA,SHROOM1,CLDN15A,PTEN,CLDN11,PARD6A |
| Amoebiasis | IL-8,COL1A2,PIK3R3,SERPINB3,COL24A1,SERPINB6,LAMC1,ITGAM,PLCB2,SERPINB1A |
| Regulation of Actin Cytoskeleton | PIK3CG,PIP5K1B,ITGA11A,FGF8A,ACTN3A,ITGB1B.2,GSN,PIP5K1C,INS,FGF22 |
| Adherens junction | MAP3K7,ACTN1,IGF1R,WASLB,FGFR1,SRC,WASF2,SNAI2,PVRL4,ERBB2 |
| Viral carcinogenesis | PRKACA,HLA-B,REL,NFKB2,GTF2B,TRP53,TP53,HIST1H2BM,MAPK1,NFKBIA |
| Focal adhesion | FLT1,IGF1RA,VCL,ITGB1A,CDC42L,ERBB2,PTK6,BCL2,VEGFAA,PAK2 |
| Systemic lupus erythematosus | H2AFY,C1QB,HIST1H2AO,HIST2H2AC,HIST1H2BB,HIST2H2BB,GRIN2A,HIST1H4C,C2,H2AFJ |
Protein Function
ACTN2 has several biochemical functions, for example, FATZ binding,LIM domain binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TWIST1,USH1G,ZBTB16,C16orf89,MYO7A,TREX2,HSPB6,GDF7,CDH13,CD8A |
| cytoskeletal protein binding | NEBL,ABI1,CDK5,LIN7C,ALDOB,CAPN1,NF2A,MYPN,EPB41L3B,NCKIPSD |
| integrin binding | ILK,COL5A1,ICAM1,COL16A1,EMP2,P4HB,CYR61L1,ICAM3,LYN,ANXA7 |
| titin Z domain binding | TCAP |
| calcium ion binding | CAPN1A,PCDHGB1,PLCG1,CDH6,STIM2,CDH5,PCDH1G32,GUCA1E,FLG,FSTL1B |
| protein domain specific binding | NLRP1,IRS2,ARFIP2,DDX20,HIST2H4A,NEFL,AKAP5,LIN7C,GNAI3,CRB3 |
| identical protein binding | MRAP2,CLDN20,COMMD1,FHL2,RCAN1,SIAH1A,TRAF2,TRAF6,CD74,ATL2 |
| ion channel binding | NEDD4L,AASS,KCND3,USP10,PRKCSH,SCN3B,SNTA1,PACS1,KCNH1,YES1 |
| thyroid hormone receptor coactivator activity | MED1,MED16,NCOA2 |
Interacting Protein
ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.
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