actn2
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  • Official Full Name
  • actinin, alpha 2
  • Background
  • Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
  • Synonyms
  • ACTN2; actinin, alpha 2; CMD1AA; alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle;
Cat.#:ACTN2-1023HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACTN2 Protein, MYC/DDK-tagged
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Cat.#:ACTN2-31382THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTN2, His-tagged
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Cat.#:ACTN2-361HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTN2 protein, His/MBP-tagged
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Cat.#:Actn2-539MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Actn2 Protein, His-tagged
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Cat.#:ACTN2-6875CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTN2
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Involved Pathway

ACTN2 involved in several pathways and played different roles in them. We selected most pathways ACTN2 participated on our site, such as Focal adhesion, Adherens junction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
VAV1; ACTN2B; PRKCB; HRASB; MYLPFB; AKT2L; VWF; MAPK4; PARVAA; ROCK2A
Adherens junction
MAPK3; WASF2; TCF7L2; PVRL1B; SSX2IPA; INSRA; AASS; PVRL3; WASF3; FYN
Tight junction
PARD3; ACTB1; RHOAA; SHROOM2; HCLS1; MYL12.1; HRAS; RAB3B; SHROOM3; HRASA
Leukocyte transendothelial migration
ITGA4; ARHGAP5; ITGAL; PTK2B; MYL10; JAM3; GNAI3; PTK2; MMP2; CLDN14
Regulation of actin cytoskeleton
RRAS2; ITGB1; Itgam&Itgb2; MAP2K2B; RHOAD; FGF2; PIP5K1AA; MYL5; FGD1; ITGAV
Amoebiasis
GNAQ; PLCB2; ACTN2; C9; TLR4; SERPINB1B; SERPINB9; VCL; COL5A2; COL24A1
Viral carcinogenesis
POLB; CCND3; RAC1; HIST1H2BO; CCNA2; ATP6V0D1; NFKBIA; TTC6; CCND1; PIK3R2
Systemic lupus erythematosus
FCGR3B; HIST1H3G; HIST1H3C; IFNG; C1QA; HIST2H4; HLA-DRB4; H3F3B; FCGR3A; HLA-DQB1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
LEF1; ITGB6; TCF7; CACNB1; CACNG7; ITGA2; ACTN1; CACNG1; ITGB5; JUP

Protein Function

ACTN2 has several biochemical functions, for example, FATZ binding, LIM domain binding, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTN2 itself. We selected most functions ACTN2 had, and list some proteins which have the same functions with ACTN2. You can find most of the proteins on our site.
Function
Related Protein
Function FATZ binding
Related Protein MYOZ1; ACTN2; TCAP
Function LIM domain binding
Related Protein LDB1B; LDB1; ACTN2; LDB2A; LDB2; TLN1; RPH3AL; LDB2B; CSRP2BP; RIPK2
Function actin filament binding
Related Protein CTNNAL1; MYO18A; MYH9; CTNNA2; ANXA8; PPP1R9A; CORO6; EGFR; TMOD1; CORO1C
Function calcium ion binding
Related Protein TMEM8C; LPCAT1; CALR3; NELL2; PCDHGA2; PCDH2G12; TPT1; PVALB9; CIB1; EDIL3
Function cytoskeletal protein binding
Related Protein EPB41L3B; PKD2; PTPN4B; TOR1A; ANXA2; EPB41L4B; NEBL; EZRA; MYLIP; CAPN2
Function identical protein binding
Related Protein SMG9; MAP3K13; L3MBTL1; TRADD; TRAF6; KHDRBS1; CBS; BRAF; MCPH1; DPP9
Function integrin binding
Related Protein KDR; ICAM1; LYN; CD226; WISP1A; ICAM3; CTGFB; DST; TLN1; ADAM15
Function ion channel binding
Related Protein GRINA; FAM115C; HOMER1; ID2; CALM1; PACS2; AP2M1; PKD1; CDH5; FYN
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein RAB35; COMMD1; TULP3; TULP1; EXOC1; SYT1; PFN2; FAM21C; RPH3A; SCIN
Function protein binding
Related Protein YAF2; SLC22A2; IKZF2; MTX2; SYNJ2BP; CCDC101; PMF1; TMIGD2; SENP6; RPL14
Function protein dimerization activity
Related Protein BHLHA15; ACTN2; NPAS1; MYCLA; ATOH7; AHRR; MYCLB; LDB1A; HIF3A; ASCL1A
Function protein domain specific binding
Related Protein WNT5A; TFDP2; WHRN; ICA1L; TACC2; PPP3R1; ST13; MITD1; ARFIP2B; FOXA2
Function protein homodimerization activity
Related Protein CRYBA2; CPOX; S100A16; CDA; AMICA1; GLA; UGT1A6B; TCF3B; HSPB6; BCL2L10
Function structural constituent of muscle
Related Protein MYL2; DMD; MYBPC2; TPM1; JPH1; MYBPC1; MYL9; MYL1; TCAP; TPM4
Function thyroid hormone receptor coactivator activity
Related Protein NCOA2; ACTN2; MED16; MED1
Function titin Z domain binding
Related Protein ACTN2; TCAP
Function titin binding
Related Protein ANKRD1; MYBPC1; CAPN3; TRIM63; CALM; ACTN2; ANKRD2; ANKRD23; SLC14A2; CALM2

Interacting Protein

ACTN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTN2.
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