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API5

  • Official Full Name

    apoptosis inhibitor 5

  • Overview

    This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    API5; apoptosis inhibitor 5; AAC 11; AAC11; API5 like 1; API5L1; fibroblast growth factor 2 interacting factor 2; migration inducing protein MIG8; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human API5-1171H Recombinant Human API5 protein, His-tagged E.coli His Pro2~Phe360
Human API5-681H Recombinant Human API5 protein, GST-tagged Wheat Germ GST
Human API5-3005H Recombinant Human API5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human API5-2310H Recombinant Human API5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human API5-301104H Recombinant Human API5 protein, GST-tagged E.coli GST Leu155-Lys504
Mouse Api5-3581M Recombinant Mouse Api5, His-tagged E.Coli or Yeast His 504
Mouse API5-1770M Recombinant Mouse API5 Protein Mammalian Cell His
Mouse API5-620M Recombinant Mouse API5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Api5-628M Recombinant Mouse Api5 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse API5-620M-B Recombinant Mouse API5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque API5-356R Recombinant Rhesus monkey API5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque API5-185R Recombinant Rhesus Macaque API5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque API5-185R-B Recombinant Rhesus Macaque API5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish API5-9945Z Recombinant Zebrafish API5 Mammalian Cell His
Chicken API5-1613C Recombinant Chicken API5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • API5 Related Articles

API5 involved in several pathways and played different roles in them. We selected most pathways API5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with API5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

API5 has several biochemical functions, for example, fibroblast growth factor binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by API5 itself. We selected most functions API5 had, and list some proteins which have the same functions with API5. You can find most of the proteins on our site.

Function Related Protein
fibroblast growth factor bindingFGFR4;SCN5A;Api5;GLG1B;FGFR1;FGFR2;S100A13;FGFR1A;RPS2
poly(A) RNA bindingTUFM;UCHL5;SRPR;CS;GNL2;RPL28;HDGF;ALG13;XRCC6

API5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with API5 here. Most of them are supplied by our site. Hope this information will be useful for your research of API5.

Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
What are the detection methods for API5 gene mutation in tumor patients? 09/17/2022

The mutation of API5 gene can be detected by PCR, sequencing, immunohistochemistry and other methods.

What is the application prospect of API5 in prognostic diagnosis? 09/11/2022

Recombinant API5 protein has an important clinical application prospect in prognostic diagnosis, and can provide an important basis for accurate treatment.

What is the role of API5 in the process of tumor metastasis? 06/26/2022

Recombinant API5 protein can promote the metastasis of tumor cells and further promote tumor growth and progression.

What are the adverse reactions of API5 in antitumor therapy? 08/30/2021

The specific adverse reactions need to be determined on a case-by-case basis. So far, studies have shown no serious adverse reactions.

How to evaluate the efficacy of API5 in tumor therapy? 07/12/2021

Clinical trials can be conducted to evaluate the efficacy of recombinant API5 protein in the treatment of tumors.

What is the prospect of recombinant API5 protein in the treatment of tumors? 06/08/2021

Current studies have shown that recombinant API5 protein can play important biological functions in cancer cells and their microenvironment, and has a wide range of therapeutic prospects.

How to improve the targeting and specificity of API5 ? 05/07/2021

The targeting and specificity of API5 can be improved by constructing targeted drugs, probes, antibodies and other means.

What is the role of API5 in tumor radiotherapy? 03/13/2021

Recombinant API5 protein can enhance the tolerance of tumor cells to radiotherapy by inhibiting apoptosis of tumor cells.

What is the main function of API5 ? 03/11/2021

API5 is an inhibitor of apoptosis, which has the function of inhibiting apoptosis in cells and promoting cell survival.

What are the interactions between API5 s and other proteins? 10/31/2020

Recombinant API5 proteins can bind to other apoptosis-related cytokines and proteins, thereby regulating cell survival and apoptosis signaling pathways.

What are the potential advantages of the combination of API5 and tumor immunotherapy? 07/08/2020

Recombinant API5 protein can enhance the effect of tumor immunotherapy by inhibiting the apoptosis of immune cells.

How to optimize the expression and purification of API5 ? 07/01/2020

The expression and purification of API5 can be optimized by optimizing the carrier, culture conditions, purification methods and other means.

How to improve the stability of API5 in vivo? 06/27/2020

The stability of API5 in vivo can be improved by building a stable expression system, nucleic acid drug targeting, nanotechnology and other means.

What is the genetic structure of API5 ? 06/11/2020

The protein encoded by the API5 gene is composed of 359 amino acids with a molecular weight of about 40kDa and contains a apoptosis inhibition domain (AID) domain.

How to detect the expression level of API5 ? 04/12/2020

The expression level of API5 can be detected by Western blot, immunohistochemistry, PCR and other methods.

How to efficiently deliver API5 to tumor cells? 01/26/2020

The recombinant API5 protein can be efficiently delivered to tumor cells by means of nanotechnology, gene transfection, cell delivery, etc.

How to evaluate the pharmacokinetics and toxicology of API5 ? 11/27/2019

The pharmacokinetics and toxicology of API5 s can be evaluated through animal studies and in vitro studies.

How to improve the biological activity of API5 ? 10/22/2019

The biological activity of API5 can be improved by point mutation, structural optimization and sensitivity improvement.

In which diseases does recombinant API5 play an important role? 07/07/2019

Recombinant API5 protein plays an important role in the occurrence, growth, metastasis and progression of a variety of tumors.

How to prepare API5 ? 04/06/2019

Recombinant API5 proteins can usually be prepared in E. coli or eukaryotic cells by gene recombination techniques.

Customer Reviews (3)

Write a review
Reviews
09/17/2022

    Characteristics of short half-life and high clearance provide greater potential for recombinant proteins in the treatment of various diseases, and are expected to become a new generation of therapeutic drugs.

    08/06/2020

      The stability of API5 is excellent, and its structure and function remain stable even after multiple freeze-thaw cycles, showing excellent product quality.

      05/16/2019

        Western blot experiments using API5 can obtain very consistent results, indicating its high repeatability and reproducibility.

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