• Official Full Name
  • apoptosis inhibitor 5
  • Background
  • This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • API5; apoptosis inhibitor 5; AAC 11; AAC11; API5 like 1; API5L1; fibroblast growth factor 2 interacting factor 2; migration inducing protein MIG8; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein
Source (Host):HEK293Species:Human
Product nameRecombinant Human API5 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human API5 protein, His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human API5 protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse API5 Protein
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Api5, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey API5 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken API5
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish API5

Protein Function

API5 has several biochemical functions, for example, fibroblast growth factor binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by API5 itself. We selected most functions API5 had, and list some proteins which have the same functions with API5. You can find most of the proteins on our site.
Related Protein
Function fibroblast growth factor binding
Related Protein HSPA9; RPS19; FIBP; FGFR2; Api5; FGFR1A; FGFR3; FGFBP1; FIBPB; FGFBP3
Function poly(A) RNA binding
Related Protein PRPF6; CDC42EP4; LGALS1; PAN3; PIN4; RPUSD4; LSM14A; SMC1A; NHP2L1; C1orf131

API5 Related Articles

Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).