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ATF6

  • Official Full Name

    activating transcription factor 6

  • Overview

    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
  • Synonyms

    ATF6; activating transcription factor 6; ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATF6-26190TH Recombinant Human ATF6, His-tagged E.coli His
Human ATF6-873H Recombinant Human ATF6, GST-tagged Wheat Germ GST
Human ATF6-144HCL Recombinant Human ATF6 cell lysate N/A
Human ATF6-0152H Recombinant Human ATF6 Protein (Met1-Thr192), N-His-tagged E.coli N-His Met1-Thr192
Human ATF6-3759H Recombinant Human ATF6 protein, GST-tagged E.coli GST 81-194 aa
Mouse ATF6-2069M Recombinant Mouse ATF6 Protein Mammalian Cell His
Mouse ATF6-2070M Recombinant Mouse Atf6 protein, His/T7-tagged E.coli His/T7 Met1~Leu377
Mouse ATF6-815M-B Recombinant Mouse ATF6 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATF6-815M Recombinant Mouse ATF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATF6-841R Recombinant Rat ATF6 Protein Mammalian Cell His
Rat ATF6-497R-B Recombinant Rat ATF6 Protein Pre-coupled Magnetic Beads HEK293
Rat ATF6-497R Recombinant Rat ATF6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL-3371HF Recombinant Full Length Human Cyclic Amp-Dependent Transcription Factor Atf-6 Alpha(Atf6) Protein, His-Tagged E.coli expression system His Full Length (1-670)
Zebrafish ATF6-6204Z Recombinant Zebrafish ATF6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATF6 Related Articles

ATF6 involved in several pathways and played different roles in them. We selected most pathways ATF6 participated on our site, such as Protein processing in endoplasmic reticulum, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumRAD23A;CAPN2;PLAA;SEC13;ERP29;DAD1;AMFR;UGGT2;LMAN1
Alzheimers diseaseNDUFB1;NDUFV2;LPL;COX6C;ADAM17;NDUFS1;EIF2AK3;PSEN2;NDUFB11

ATF6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, cAMP response element binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF6 itself. We selected most functions ATF6 had, and list some proteins which have the same functions with ATF6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingOSR2;SP1;ZSCAN2;ZNF480;TRP53;PHOX2B;XBP1;DMBX1;KLF12
cAMP response element bindingCREB3L3;CREB1;CREB3;CREB3L3A;CREB3L2;CREB3L1;HMGA2;ATF6B;E4F1
protein bindingC12orf5;MIEN1;DUSP19;CTAGE5;GIMAP5;PEX5;SDC1;CCPG1;TNS4
protein heterodimerization activityIRAK1;LTC4S;MAFGB;HER1;PKNOX1;HIST1H2AI;IRAK2;SOX15;RRAGD
transcription coactivator activityACTL6B;NR1I3;KDM5A;PIAS2;TAF7L;TADA3;E4F1;CALCOCO1;GTF2A1L
transcription factor activity, sequence-specific DNA bindingFOXI3A;ZSCAN4C;ATOH1;ZNF193;MYT1;KLF5;NR1D2A;HOXC5;TBX6

ATF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF6.

CREB3L3; XBP1; Klc2; BPGM; CREB1; TNFRSF1A; DDC; p27958-pro_0000037575; NNMT; BALF4 (provisional); NFYC; dppA; papC; fhuB; q8d1i7_yerpe; y1009_yerpe

Wang, JJ; Cheng, QY; et al. Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus. AMERICAN JOURNAL OF THE MEDICAL SCIENCES 348:465-473(2014).
Park, KS; Bayles, I; et al. Transcription Elongation Factor ELL2 Drives Ig Secretory-Specific mRNA Production and the Unfolded Protein Response. JOURNAL OF IMMUNOLOGY 193:4663-4674(2014).
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