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AVEN

  • Official Full Name

    apoptosis, caspase activation inhibitor

  • Overview

    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.
  • Synonyms

    AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; OTTHUMP00000159733;

  • Recombinant Proteins
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • DYKDDDDK
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AVEN-1041H Recombinant Human AVEN protein, GST-tagged Wheat Germ GST
Human AVEN-3208H Recombinant Human AVEN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AVEN-01H Recombinant Human AVEN Protein, DYKDDDDK-tagged Human Cell DYKDDDDK
Human AVEN-3034H Recombinant Human AVEN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AVEN-1254HF Recombinant Full Length Human AVEN Protein, GST-tagged In Vitro Cell Free System GST 362 amino acids
Mouse Aven-1790M Recombinant Mouse Aven Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish AVEN-4283Z Recombinant Zebrafish AVEN Mammalian Cell His
Chicken AVEN-1249C Recombinant Chicken AVEN Mammalian Cell His
  • AVEN Related Articles

AVEN involved in several pathways and played different roles in them. We selected most pathways AVEN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AVEN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AVEN has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by AVEN itself. We selected most functions AVEN had, and list some proteins which have the same functions with AVEN. You can find most of the proteins on our site.

Function Related Protein

AVEN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AVEN here. Most of them are supplied by our site. Hope this information will be useful for your research of AVEN.

Potty, ASR; Xenopoulos, A; et al. The Effect of Antiapoptosis Genes on Clarification Performance. BIOTECHNOLOGY PROGRESS 30:100-107(2014).
Ha, TK; Jeon, MK; et al. Effect of Bcl-x(L) Overexpression on Lactate Metabolism in Chinese Hamster Ovary Cells Producing Antibody. BIOTECHNOLOGY PROGRESS 29:1594-1598(2013).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What diseases are associated with AVEN? 12/30/2022

AVEN has been implicated in the development of some cancers, particularly acute promyelocytic leukemia (APL). The high expression of AVEN is closely related to the pathogenesis of APL.

How do you regulate AVEN's activities? 12/03/2022

The activity of AVEN can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These regulatory mechanisms can affect the function of AVEN.

What are the potential applications of AVEN in cancer therapy? 09/06/2022

Potential applications of AVEN in cancer therapy include therapeutic targets, diagnostic markers, and drug development candidates. Drug development for AVEN may help treat certain types of cancer.

Does AVEN inhibit apoptosis? 06/14/2022

It can interact with other members of the Bcl-2 protein family to inhibit the activation of the mitochondrial apoptotic pathway by blocking the activation of the pro-apoptotic proteins Bax and Bak.

Does AVEN function differently in different cell types? 12/06/2021

The role of AVEN in different types of cells may vary. Its function may be affected by factors such as cell type, tissue, and stage of development.

How is the expression level of AVEN regulated? 11/02/2020

The expression level of AVEN is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the AVEN gene, thereby regulating its expression level in cells.

Customer Reviews (3)

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Reviews
03/22/2023

    Endotoxin levels are low and do not interfere with the experimental results.

    03/10/2021

      AVEN is highly expressed and can be easily detected.

      06/30/2020

        It performs well in Western blots, even if stored for a long time, it will not affect its performance.

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