• Official Full Name
  • apoptosis, caspase activation inhibitor
  • Background
  • Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.
  • Synonyms
  • AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; OTTHUMP00000159733
Source (Host):HEK293Species:Human
Product nameRecombinant Human AVEN Protein, MYC/DDK-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AVEN protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AVEN
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AVEN

AVEN Related Articles

Potty, ASR; Xenopoulos, A; et al. The Effect of Antiapoptosis Genes on Clarification Performance. BIOTECHNOLOGY PROGRESS 30:100-107(2014).
Ha, TK; Jeon, MK; et al. Effect of Bcl-x(L) Overexpression on Lactate Metabolism in Chinese Hamster Ovary Cells Producing Antibody. BIOTECHNOLOGY PROGRESS 29:1594-1598(2013).