Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed;under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid;tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels;as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1;contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced;by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along;with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53.BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth;suppressor of glioblastomas.
BAI1 involved in several pathways and played different roles in them. We selected most pathways BAI1 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAI1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
BAI1 has several biochemical functions, for example, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BAI1 itself. We selected most functions BAI1 had, and list some proteins which have the same functions with BAI1. You can find most of the proteins on our site.
Function G-protein coupled receptor activity
Related Protein CXCR4; S1PR5A; GPRC5BB; FZD5; MRGPRB3; OLFR13; FPR-RS4; LPAR2B; PTGER4C; TPRA1
BAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAI1.
MAGI3; BAIAP3; EIF3H; Dlg4
BAI1 Related Articles
Sokolowski, JD; Nobles, SL; et al. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor. BRAIN BEHAVIOR AND IMMUNITY 25:915-921(2011).
Zhao, P; Gao, CF; et al. Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells. CANCER LETTERS 291:209-216(2010).