Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

CYP7B1

  • Official Full Name

    cytochrome P450, family 7, subfamily B, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
  • Synonyms

    CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha hydroxylase), polypeptide 1 , spastic paraplegia 5A (autosomal recessive) , SPG5A; 25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P45;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP7B1-2292H Recombinant Human CYP7B1 Protein, GST-tagged Wheat Germ GST
Human CYP7B1-7098HCL Recombinant Human CYP7B1 293 Cell Lysate HEK293 N/A
Human CYP7B1-2484HF Recombinant Full Length Human CYP7B1 Protein, GST-tagged In Vitro Cell Free System GST 506 amino acids
Mouse Cyp7b1-2426M Recombinant Mouse Cyp7b1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CYP7B1-1758R Recombinant Rat CYP7B1 Protein Mammalian Cell His
Rat CYP7B1-1417R Recombinant Rat CYP7B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CYP7B1-1417R-B Recombinant Rat CYP7B1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYP7B1 involved in several pathways and played different roles in them. We selected most pathways CYP7B1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Primary bile acid biosynthesisCYP46A1.3;CH25HL1.2;CH25H;ACOX2;SCP2;CH25HL2;CYP7A1A;AKR1C4;CYP46A1.2
Steroid hormone biosynthesisCYP1A;UGT1A6;HSD17B8;UGT1A9;SULT1E1;CYP3A65;CYP2C38;SRD5A3;COMTA

CYP7B1 has several biochemical functions, for example, 25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7B1 itself. We selected most functions CYP7B1 had, and list some proteins which have the same functions with CYP7B1. You can find most of the proteins on our site.

Function Related Protein
25-hydroxycholesterol 7alpha-hydroxylase activity
heme bindingIDO1;EIF2AK1;CYP1A;NOS1;CYP2K17;AMBP;NOX5;CYP4V2;CYP27C1
iron ion bindingAOX1;AOX3L1;CYP46A1.3;EGLN1B;CYP4V7;CYP2K19;BA1;CYP2R1;CYP17A2
oxysterol 7-alpha-hydroxylase activity

CYP7B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7B1.

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does the CYP7B1 protein contribute to steroid hormone synthesis? 05/05/2018

CYP7B1 is involved in the conversion of dehydroepiandrosterone (DHEA) into 7α-hydroxy-DHEA, which can further be metabolized into active androgenic and estrogenic steroids.

Can abnormalities in CYP7B1 expression or function lead to metabolic disorders? 08/23/2017

Dysregulation of CYP7B1 activity can contribute to disruptions in bile acid homeostasis, potentially leading to metabolic disorders such as cholestasis or dyslipidemia.

Are there any pharmacological agents targeting CYP7B1 for therapeutic purposes? 07/10/2017

While no specific drugs targeting CYP7B1 are currently available, research into modulating CYP7B1 activity may hold promise for future therapeutic interventions.

What diagnostic tests are available to assess CYP7B1 protein levels or function? 03/19/2017

Genetic testing for mutations in the CYP7B1 gene and biochemical assays measuring bile acid intermediates may be used to assess CYP7B1 protein function.

Are there any therapeutic implications of CYP7B1 in hormone-related conditions? 09/24/2016

Understanding the role of CYP7B1 in steroid hormone synthesis may offer potential therapeutic targets for conditions such as hormone-dependent cancers or endocrine disorders.

Customer Reviews (3)

Write a review
Reviews
11/27/2022

    Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.

    11/15/2021

      Incorporating the CYP7B1 protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.

      04/06/2018

        Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.

        Ask a Question for All CYP7B1 Products

        Required fields are marked with *

        My Review for All CYP7B1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends