CYP7B1
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Official Full Name
cytochrome P450, family 7, subfamily B, polypeptide 1
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Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. -
Synonyms
CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha hydroxylase), polypeptide 1 , spastic paraplegia 5A (autosomal recessive) , SPG5A; 25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P45;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CYP7B1-2292H | Recombinant Human CYP7B1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | CYP7B1-7098HCL | Recombinant Human CYP7B1 293 Cell Lysate | HEK293 | N/A | ||
Human | CYP7B1-2484HF | Recombinant Full Length Human CYP7B1 Protein, GST-tagged | In Vitro Cell Free System | GST | 506 amino acids | |
Mouse | Cyp7b1-2426M | Recombinant Mouse Cyp7b1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | CYP7B1-1758R | Recombinant Rat CYP7B1 Protein | Mammalian Cell | His | ||
Rat | CYP7B1-1417R | Recombinant Rat CYP7B1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CYP7B1-1417R-B | Recombinant Rat CYP7B1 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
CYP7B1 involved in several pathways and played different roles in them. We selected most pathways CYP7B1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Primary bile acid biosynthesis | CYP46A1.3;CH25HL1.2;CH25H;ACOX2;SCP2;CH25HL2;CYP7A1A;AKR1C4;CYP46A1.2 |
Steroid hormone biosynthesis | CYP1A;UGT1A6;HSD17B8;UGT1A9;SULT1E1;CYP3A65;CYP2C38;SRD5A3;COMTA |
CYP7B1 has several biochemical functions, for example, 25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7B1 itself. We selected most functions CYP7B1 had, and list some proteins which have the same functions with CYP7B1. You can find most of the proteins on our site.
Function | Related Protein |
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25-hydroxycholesterol 7alpha-hydroxylase activity | |
heme binding | IDO1;EIF2AK1;CYP1A;NOS1;CYP2K17;AMBP;NOX5;CYP4V2;CYP27C1 |
iron ion binding | AOX1;AOX3L1;CYP46A1.3;EGLN1B;CYP4V7;CYP2K19;BA1;CYP2R1;CYP17A2 |
oxysterol 7-alpha-hydroxylase activity |
CYP7B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7B1.
- Q&As
- Reviews
Q&As (5)
Ask a questionCYP7B1 is involved in the conversion of dehydroepiandrosterone (DHEA) into 7α-hydroxy-DHEA, which can further be metabolized into active androgenic and estrogenic steroids.
Dysregulation of CYP7B1 activity can contribute to disruptions in bile acid homeostasis, potentially leading to metabolic disorders such as cholestasis or dyslipidemia.
While no specific drugs targeting CYP7B1 are currently available, research into modulating CYP7B1 activity may hold promise for future therapeutic interventions.
Genetic testing for mutations in the CYP7B1 gene and biochemical assays measuring bile acid intermediates may be used to assess CYP7B1 protein function.
Understanding the role of CYP7B1 in steroid hormone synthesis may offer potential therapeutic targets for conditions such as hormone-dependent cancers or endocrine disorders.
Customer Reviews (3)
Write a reviewIts robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.
Incorporating the CYP7B1 protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.
Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.
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