• Official Full Name
  • cytochrome P450, family 7, subfamily B, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
  • Synonyms
  • CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha hydroxylase), polypeptide 1 , spastic paraplegia 5A (autosomal recessive) , SPG5A; 25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P45
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP7B1 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CYP7B1 Protein
Source (Host):Species:Human
Product nameRecombinant Human CYP7B1 293 Cell Lysate

Involved Pathway

CYP7B1 involved in several pathways and played different roles in them. We selected most pathways CYP7B1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Primary bile acid biosynthesis
SCP2; CH25HL2; ACOX2; BRSK2; CH25H; AMACR; HSD3B7; CYP46A1.1; AKR1D1; CH25HL1.2
Steroid hormone biosynthesis

Protein Function

CYP7B1 has several biochemical functions, for example, 25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7B1 itself. We selected most functions CYP7B1 had, and list some proteins which have the same functions with CYP7B1. You can find most of the proteins on our site.
Related Protein
Function 25-hydroxycholesterol 7alpha-hydroxylase activity
Related Protein CYP7B1
Function heme binding
Related Protein CYP21A2; NOX4; HBD; PGRMC1; CYP4Z1; PTGS2A; SRC; HBAE3; CYP2P9; SDHC
Function iron ion binding
Related Protein ETHE1; P4HA1; CYP27A1; TPH2; ISCU; P4HA1B; PLOD1A; TYW1; CYP2AA2; ALKBH8
Function oxysterol 7-alpha-hydroxylase activity
Related Protein CYP7B1