The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias.
Wheeler, ML; Dong, MB; et al. Diacylglycerol Kinase zeta Limits B Cell Antigen Receptor-Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses. SCIENCE SIGNALING 6:-(2013).
Toriumi, K; Horikoshi, Y; et al. Carbon tetrachloride-induced hepatic injury through formation of oxidized diacylglycerol and activation of the PKC/NF-kappa B pathway. LABORATORY INVESTIGATION 93:218-229(2013).