• Official Full Name
  • deiodinase, iodothyronine, type III
  • Background
  • The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
  • Synonyms
  • DIO3; deiodinase, iodothyronine, type III; TXDI3; type III iodothyronine deiodinase; Type 3 DI; D3; 5DIII; Deiodinase iodothyronine type 3; Deiodinase iodothyronine type III; Dio 3; DIOIII; MGC124117; MGC124118; type-III 5 deiodinase; type-III 5-deiodinase; type 3 iodothyronine selenodeiodinase; iodothyronine deiodinase, placental type; thyroxine deiodinase type III (selenoprotein)
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat DIO3 Protein (37-278 aa), His-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DIO3 Protein, GST-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat DIO3 Protein, His/MBP-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DIO3 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat DIO3 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DIO3

Involved Pathway

DIO3 involved in several pathways and played different roles in them. We selected most pathways DIO3 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway

Protein Function

DIO3 has several biochemical functions, for example, oxidoreductase activity, thyroxine 5-deiodinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO3 itself. We selected most functions DIO3 had, and list some proteins which have the same functions with DIO3. You can find most of the proteins on our site.
Related Protein
Function oxidoreductase activity
Related Protein CYP4A14; CYP4V7; HADHAB; GMPR2; TXNRD3; ALDH9A1B; CYP2AA3; TYRP1B; Aldh1a7; CYP2AD2
Function thyroxine 5-deiodinase activity
Related Protein DIO1; DIO3; DIO3A; DIO3B; DIO2