ep400
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  • Official Full Name
  • E1A binding protein p400
  • Background
  • Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.
  • Synonyms
  • EP400;E1A binding protein p400;Rabbit;Human;Rabbit Anti-Human EP400 Polyclonal Antibody;Rabbit Anti-Human EP400;Polyclonal Antibody;Rabbit Anti-Human EP400 Antibody;Polyclonal;Rabbit Anti-Human EP400 Polyclonal;Antibody;Rabbit Anti-Human E1A binding protein p400 Antibody;Rabbit Anti-Human E1A binding protein p400 Polyclonal;Anti-Human EP400 Antibody;Anti-Human EP400 Polyclonal;Anti-Human E1A binding protein p400 Antibody;Anti-Human E1A binding protein p400 Polyclonal;Anti-Human EP400;Anti-EP400;Anti-Human E1A binding protein p400;Anti-E1A binding protein p400;
Cat.#:EP400-3347HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EP400 Protein, GST-tagged
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Cat.#:EP400-2361CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EP400
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Cat.#:EP400-559HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EP400 cell lysate
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Involved Pathway

EP400 involved in several pathways and played different roles in them. We selected most pathways EP400 participated on our site, such as Cellular Senescence, Cellular responses to stress, Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP400 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular Senescence
E2F3; H1F0; Txn1; PHC3; CBX4; PHC2; POT1A; AGO1; HIST1H1E; ERF
Cellular responses to stress
EED; RB1CC1; HBXIP; AGO1; WIPI2; NUPL2; HIST3H2BB; AMBRA1; DYNLL2A; KDM6B
Chromatin modifying enzymes
GATAD2B; PADI4; HMG20B; PRMT7; KDM5D; KAT7; MSL2B; SAP30L; ELP4; MBIP
Chromatin organization
KDM3B; ANO9A; KDM5C; PADI1; MTA1; KDM3A; SMARCA4; ATF7IP; PRDM16; KAT7B
DNA Damage/Telomere Stress Induced Senescence
POT1A; HMGA1-RS1; CABIN1; RAD50; HMGA1B; HIST1H1D; HTATIP; HIRA; H1F0; TERF2IP
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
H1F0; HMGA1-RS1; HIST1H1C; HIST1H1B; CABIN1; HIST1H1D; ASF1A; HIRA; HMGA1B; EP400
HATs acetylate histones
PHF20B; BRD8; MSL1A; MORF4L1; DMAP1; MEAF6; KANSL2; MSL2; ACTL6A; C20orf20

Protein Function

EP400 has several biochemical functions, for example, ATP binding, DNA binding, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EP400 itself. We selected most functions EP400 had, and list some proteins which have the same functions with EP400. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYH1; DYRK2; RUNX2A; NLRC4; KITA; JAK2; PKN3; GNE; ATP13A1; RIOK1
Function DNA binding
Related Protein TLR8; VEPH1; ZNF302; SYCP2; SOX19A; ZNF182; HIST2H2AC; ZNF468; ZNF582; PLAGL1
Function helicase activity
Related Protein UPF1; HLTF; DDX58; MCM6L; HELZ2; TDRD12; MCM9; DHX57; PL10; SMARCA4
Function protein binding
Related Protein ECE2; SCO1; TANK; TOR1B; TBL1XR1; CCDC109A; NUCB1; ABL2; MYOD1; SLC9A3R2

Interacting Protein

EP400 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP400 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP400.
ALAS1; MYC; Dlg4; ACTL6A; FOS; PARP1; BRD8; RUVBL2; TBC1D4; ESR1; MRGBP; DYRK1B