ercc1
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  • Official Full Name
  • excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
  • Background
  • The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.
  • Synonyms
  • ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4
Cat.#:ERCC1-3455HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERCC1 Protein, GST-tagged
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Cat.#:ERCC1-12521HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC1, GST-tagged
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Cat.#:ERCC1-2396HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC1
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Cat.#:ERCC1-28691THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC1
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Cat.#:ERCC1-6778HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERCC1, His-tagged
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Cat.#:ERCC1-5967ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERCC1
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Cat.#:ERCC1-6567HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC1 293 Cell Lysate
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Cat.#:ERCC1-6568HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ERCC1 293 Cell Lysate
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Involved Pathway

ERCC1 involved in several pathways and played different roles in them. We selected most pathways ERCC1 participated on our site, such as Nucleotide excision repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
GTF2H5; COPS3; RAD23B; ERCC6; ERCC3; XPC; CUL4A; USP45; RPA3; RFC4
Fanconi anemia pathway
SLX4; RPA4; C19orf40; HER6; UBE2T; POLN; RMI1; HES1; REV1; STRA13

Protein Function

ERCC1 has several biochemical functions, for example, TFIID-class transcription factor binding, damaged DNA binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC1 itself. We selected most functions ERCC1 had, and list some proteins which have the same functions with ERCC1. You can find most of the proteins on our site.
Function
Related Protein
Function TFIID-class transcription factor binding
Related Protein ZNHIT6; ERCC4; ERCC1; FBL; NOP58
Function damaged DNA binding
Related Protein CRY2; FANCG; APTX; TRPC2; TP53; RBBP8; PNKP; RPA2; EP300; BRCA1
Function protein C-terminus binding
Related Protein ATXN2; PPP2CA; MLLT4; MID1IP1; HSPB7; TCF4; SIAH1; ABL1; CORO1A; PQBP1
Function protein binding
Related Protein KLHL7; CLIC5; LETMD1; FRMD6; ZC3H11A; EEF2; MPHOSPH6; MSLN; MED11; ZFP259
Function protein domain specific binding
Related Protein DDX6; TACC1; NR0B1; VPS4A; FAF1; BASP1; HIST1H4D; ST13; TACC3; MRPL17
Function single-stranded DNA binding
Related Protein SSBP3A; FBXO18; CNBP; XPC; MLH3; HSPD1; SUB1; TTC6; PCBP1; NEIL3
Function contributes_to single-stranded DNA endodeoxyribonuclease activity
Related Protein RAD50; ERCC1
Function contributes_to structure-specific DNA binding
Related Protein ERCC1; ERCC4

Interacting Protein

ERCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC1.
UBL7; SLX4; EGFR

ERCC1 Related Articles

Kuhlmann, JD; Wimberger, P; et al. ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance. CLINICAL CHEMISTRY 60:1282-1289(2014).
Dudas, J; Schartinger, VH; et al. Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer. TUMOR BIOLOGY 35:7807-7819(2014).