ERCC1
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Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
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Overview
The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. -
Synonyms
ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ERCC1 Related Articles
- ERCC1 Related Research Area
ERCC1 involved in several pathways and played different roles in them. We selected most pathways ERCC1 participated on our site, such as Nucleotide excision repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide excision repair | RFC1;ERCC5;INO80B;ERCC4;ERCC3;GTF2H1;INO80E;RPA4;COPS5 |
| Fanconi anemia pathway | POLN;BLM;MUS81;WDR48;CDK5R2;RMI1;FANCG;POLI;FANCB |
ERCC1 has several biochemical functions, for example, TFIID-class transcription factor binding, damaged DNA binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC1 itself. We selected most functions ERCC1 had, and list some proteins which have the same functions with ERCC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TFIID-class transcription factor binding | ZNHIT6;ERCC1;FBL;NOP58;ERCC4 |
| damaged DNA binding | RAD23A;TP53BP1;XRCC6;RBBP8;HMGB2;FANCG;ERCC3;XRCC1;POLB |
| protein C-terminus binding | SHANK3;VGLL2;PPP1R9B;LIG4;AGO2;PDZD11;MID1IP1;SDCBP2;NCF2 |
| protein binding | POLD1;PPP1R12B;ALDH3A1;SERPINC1;INO80;NPHP1;GNPDA2;NOMO2;DBNDD2 |
| protein domain specific binding | ARFIP2;FOXH1;KCTD13;CHMP1A;STAMBP;PTPN11;LIN7B;SHROOM2;TJP2 |
| single-stranded DNA binding | HMGB1;FBXO18;CTC1;PMS1;RAD51AP1;ALYREF;TEN1;OBFC1;XRCC2 |
| contributes_to single-stranded DNA endodeoxyribonuclease activity | ERCC1;RAD50 |
| contributes_to structure-specific DNA binding | ERCC1;ERCC4 |
ERCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC1.
UBL7; SLX4; EGFR
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