ERCC1

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ERCC1

Official Full Name excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Background The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.
Synonyms ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ERCC1-12521H Recombinant Human ERCC1, GST-tagged E.coli GST
    Human ERCC1-2396H Recombinant Human ERCC1 E.coli N/A
    Human ERCC1-28691TH Recombinant Human ERCC1 E.coli N/A
    Human ERCC1-3455H Recombinant Human ERCC1 Protein, GST-tagged Wheat Germ GST
    Human ERCC1-6567HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 N/A
    Human ERCC1-6568HCL Recombinant Human ERCC1 293 Cell Lysate HEK293 N/A
    Human ERCC1-6778H Recombinant Human ERCC1, His-tagged E.coli His
    Zebrafish ERCC1-5967Z Recombinant Zebrafish ERCC1 Mammalian Cell His

    ERCC1 involved in several pathways and played different roles in them. We selected most pathways ERCC1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERCC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nucleotide excision repair NFRKB; RFC1; POLD2; MNAT1; ZNF830; GTF2H4; ERCC6; RPA2; RFC2; INO80C
    Fanconi anemia pathway FAN1; RPA3; POLI; PMS2; POLN; RPA4; BRCA2; BRCA1; MLH1; CDK5R2

    ERCC1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by ERCC1 itself. We selected most functions ERCC1 had, and list some proteins which have the same functions with ERCC1. You can find most of the proteins on our site.

    Function Related Protein
    TFIID-class transcription factor binding ZNHIT6; ERCC1; FBL; NOP58; ERCC4
    damaged DNA binding NEIL3; POLI; ERCC1; TRP63; TDG; CRY-DASH; XRCC5; BRCA1; HMGB1; FEN1
    protein C-terminus binding PEX16; PHB; PPP1R9B; FIGN; JAK2; SDC1; NCF2; GRIP1; VGLL3; ERCC3
    protein binding OLA1; SEMA4C; ZFP932; SMIM3; STEAP3; CDK2; ZNF180; DHX15; PELI3; CHD4
    protein domain specific binding E2F4; VAPA; TJP1; GSN; SFN; MPP7; DICER1; CNTROB; NEFL; SERPINB1A
    single-stranded DNA binding POLR2GL; C10orf2; RAD23B; ALYREF; ERCC4; CSDA; TSNAX; RAD51C; SSBP3A; CNBPA
    contributes_to single-stranded DNA endodeoxyribonuclease activity ERCC1; RAD50
    contributes_to structure-specific DNA binding ERCC1; ERCC4

    ERCC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERCC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERCC1.

    UBL7; SLX4; EGFR

    Kuhlmann, JD; Wimberger, P; et al. ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance. CLINICAL CHEMISTRY 60:1282-1289(2014).
    Dudas, J; Schartinger, VH; et al. Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer. TUMOR BIOLOGY 35:7807-7819(2014).

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