Recombinant Human ERCC1 Protein, GST-tagged

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Recombinant Human ERCC1 Protein, GST-tagged

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Cat.No. : ERCC1-3455H
Product Overview : Human ERCC1 full-length ORF ( NP_973730.1, 1 a.a. - 323 a.a.) recombinant protein with GST-tag at N-terminal.
Description : The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 62 kDa
AA Sequence : MDPGKDKEGVPQPSG PPARKKFVIPLDEDE VPPGVAKPLFRSTQS LPTVDTSAQAAPQTY AEYAISQPLEGAGAT CPTGSEPLAGETPNQ ALKPGAKSNSIIVSP RQRGNPVLKFVRNVP WEFGDVIPDYVLGQS TCALFLSLRYHNLHP DYIHGRLQSLGKNFA LRVLLVQVDVKDPQQ ALKELAKMCILADCT LILAWSPEEAGRYLE TYKAYEQKPADLLME KLEQDFVSRVTECLT TVKSVNKTDSQTLLT TFGSLEQLIAASRED LALCPGLGPQKVRAL GKNPRSWGKERAPNK HNLRPQSFKVKKEPK TRHSGFRL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) [ Homo sapiens ]
Official Symbol : ERCC1
Synonyms : ERCC1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); DNA excision repair protein ERCC-1; RAD10; UV20; COFS4;
Gene ID : 2067
mRNA Refseq : NM_001166049
Protein Refseq : NP_001159521
MIM : 126380
UniProt ID : P07992

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