fmo2
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  • Official Full Name
  • flavin containing monooxygenase 2 (non-functional)
  • Background
  • The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
  • Synonyms
  • FMO2; flavin containing monooxygenase 2 (non-functional); flavin containing monooxygenase 2; dimethylaniline monooxygenase [N-oxide-forming] 2; MGC28212; OTTMUSP00000028687; 2310008D08Rik; 2310042I22Rik; AW107733; Dimethylaniline monooxygenase [N oxide forming] 2; Dimethylaniline oxidase 2; Flavin containing monooxygenase 2 (non functional); FLJ40826; FMO 1B1; FMO 2; FMO; FMO pulmonary; FMO1B1; OTTMUSP00000028686; Pulmonary flavin containing monooxygenase 2; FMO, pulmonary; pulmonary flavin-containing monooxygenase 2
Cat.#:FMO2-4392HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FMO2 Protein, GST-tagged
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Cat.#:FMO2-736HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FMO2 Protein, His-tagged
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Cat.#:Fmo2-737RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fmo2 Protein, His-tagged
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Cat.#:FMO2-5938MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FMO2 Protein
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Cat.#:FMO2-1730RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FMO2 Protein, His-tagged
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Cat.#:FMO2-6183HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FMO2 293 Cell Lysate
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Involved Pathway

FMO2 involved in several pathways and played different roles in them. We selected most pathways FMO2 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Drug metabolism - cytochrome P
MAOA; GSTM7; GSTT1B; FMO3; UGT1A7C; FMO6P; GSTT2B; UGT2B15; UGT1AB; UGT2A3

Protein Function

FMO2 has several biochemical functions, for example, N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO2 itself. We selected most functions FMO2 had, and list some proteins which have the same functions with FMO2. You can find most of the proteins on our site.
Function
Related Protein
Function N,N-dimethylaniline monooxygenase activity
Related Protein FMO1; FMO2; FMO5; FMO3
Function NADP binding
Related Protein FMO2; ASPDH; POR; SPR; MIOX; NDOR1; FMO3; NOS2; HMGCRB; CRYZL1
Function flavin adenine dinucleotide binding
Related Protein NOX4; AOX1; NOS3; DUS1L; ACOX1; ACAD11; AIFM3; DUS4L; ACOX2; XDH
Function monooxygenase activity
Related Protein CH25HL2; CYP20A1; CYP3A5; CYP17A2; CYP3C4; CYP2V1; CYP21A1; CYP2B6; CYP2B19; YWHAE1

Interacting Protein

FMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO2.
q81qv1_bacan; ilvC2

FMO2 Related Articles

Pruitt, SR; Bertoni, C; et al. Efficient and Accurate Fragmentation Methods. ACCOUNTS OF CHEMICAL RESEARCH 47:2786-2794(2014).
Kitsukawa, M; Tsuchiyama, H; et al. Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA). JOURNAL OF TOXICOLOGICAL SCIENCES 39:545-550(2014).