fut4
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  • Official Full Name
  • fucosyltransferase 4 (alpha (1,3) fucosyltranasferase,myeloid-specific)
  • Background
  • The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).
  • Synonyms
  • LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV; FUT4; alpha-(1,3)-fucosyltransferase; Lewis X; fucT-IV; OTTHUMP 00000236888; fucosyltransferase IV; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; galactoside 3-L-fucosyltransferase; stage-specific embryonic antigen 1
Cat.#:FUT4-4563HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FUT4 Protein, GST-tagged
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Cat.#:FUT4-13044HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FUT4, His-tagged
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Cat.#:FUT4-3288HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FUT4, His-tagged
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Cat.#:Fut4-1447MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fut4 protein, His & T7-tagged
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Cat.#:FUT4-6093MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse FUT4 Protein
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Cat.#:FUT4-3134CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FUT4
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Involved Pathway

FUT4 involved in several pathways and played different roles in them. We selected most pathways FUT4 participated on our site, such as Other types of O-glycan biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Other types of O-glycan biosynthesis
B3GAT1; COLGALT2; ST6GAL2; MFNG; B3GAT2; B4GALT1; B4GALT2; LFNG; B4GALT3; FUT9
Glycosphingolipid biosynthesis - lacto and neolacto series
B3GNT2B; B3GNT3; B3GNTL2; B4GALT4; ST3GAL3B; GGTA1; B4GALT2; ST3GAL6; B3GALT5; B3GNT5B
Metabolic pathways
GGT1A; ALDH2.2; URAH; PIP5K1C; CTPS2; PDHA1B; MTHFD2; SUCLG2; XYLT2; ASMT

Protein Function

FUT4 has several biochemical functions, for example, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT4 itself. We selected most functions FUT4 had, and list some proteins which have the same functions with FUT4. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-(1->3)-fucosyltransferase activity
Related Protein B3GNT9; POC1BL; FUT11; POMGNT2; GALNTL4; DPY19L1; GLT8D1; B3GNT8; FUT9; FUT4
Function fucosyltransferase activity
Related Protein GLT8D1; UGGT1; FUT9B; GALNTL4; FUT4; FT2; FUT9; POC1BL; DPY19L1; B3GNT8

FUT4 Related Articles

Shan, X; Aziz, F; et al. Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1667-1676(2015).
Poulain, M; Frydman, N; et al. Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies. MOLECULAR HUMAN REPRODUCTION 20:960-971(2014).