GRIK3 Protein, glutamate receptor, ionotropic, kainate 3


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Official Full Name glutamate receptor, ionotropic, kainate 3
Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
Synonyms GRIK3; glutamate receptor, ionotropic, kainate 3; glutamate receptor, ionotropic kainate 3; GLUR7; EAA5; Excitatory amino acid receptor 5; GLR 7; GLR7; GLU R7; GLUR 7; GluR 7a; GluR7a; Glutamate receptor 7; Glutamate receptor ionotropic kainate 3; GRIK 3; gluR-7; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRIK3-5338H Recombinant Human GRIK3 Protein, GST-tagged Wheat Germ GST
    Mouse GRIK3-7266M Recombinant Mouse GRIK3 Protein Mammalian Cell His
    Rat GRIK3-2697R Recombinant Rat GRIK3 Protein Mammalian Cell His

    GRIK3 involved in several pathways and played different roles in them. We selected most pathways GRIK3 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction GALR2; CHRNE; DRD4B; NR3C1; TAAR14F; CHRNA10; GABRG1; TACR1A; CYSLTR2; CSH1
    Glutamatergic synapse SHANK2; HOMER2; GRM6; GRIN2C; GNG7; PPP3R2; GRIN1; SLC1A7; TRPC1; SLC1A3

    GRIK3 has several biochemical functions, for example, adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, extracellular-glutamate-gated ion channel activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK3 itself. We selected most functions GRIK3 had, and list some proteins which have the same functions with GRIK3. You can find most of the proteins on our site.

    Function Related Protein
    adenylate cyclase inhibiting G-protein coupled glutamate receptor activity GRIK3
    extracellular-glutamate-gated ion channel activity GRIN1; GRIN3B; GRIA4; GRIK5; GRID2; GRIA1A; GRIA2; GRIN2C; GRIK3; GRIK4
    glutamate receptor activity GRM8; GRM2; GRIK3; GRM7; GRM3; GRM1; GRID2; GRIA1; GRM5; GRIK5
    ion channel activity CHRNB3; KCNV2; CATSPER2; KCNH1B; P2RX3A; KCNG4A; GRIA2B; KCNH5; AKR1C1; TRPM1A
    ionotropic glutamate receptor activity GRIN2BB; GRIK3; KBP; GRIA1B; GRIN2A; GRIA2A; GRID2; GRIA4B; GRIA4; GRIN3B
    kainate selective glutamate receptor activity GRIK2; GRIK3; GRIK1; GRIK5; GRIK4
    protein binding MCRS1; TBC1D15; CDC42EP4; ZBTB43; CENPO; TBC1D7; UQCC1; TEX19.1; ACTN2; ARFIP2
    receptor activity CD200R2; GRIN2BB; SELS; CD93; CD200R3; VMN1R46; CD244; ANTXR2B; GRIA2A; EIF2D

    GRIK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK3.

    Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).
    Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).

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