grik3
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  • Official Full Name
  • glutamate receptor, ionotropic, kainate 3
  • Background
  • Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
  • Synonyms
  • GRIK3; glutamate receptor, ionotropic, kainate 3; glutamate receptor, ionotropic kainate 3; GLUR7; EAA5; Excitatory amino acid receptor 5; GLR 7; GLR7; GLU R7; GLUR 7; GluR 7a; GluR7a; Glutamate receptor 7; Glutamate receptor ionotropic kainate 3; GRIK 3; gluR-7; dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
Cat.#:GRIK3-5338HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRIK3 Protein, GST-tagged
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Cat.#:GRIK3-7266MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GRIK3 Protein
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Cat.#:GRIK3-2697RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRIK3 Protein
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Involved Pathway

GRIK3 involved in several pathways and played different roles in them. We selected most pathways GRIK3 participated on our site, such as Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
MC5RA; HTR2A; CHRNA1; NPBWR2; F2; GRIN2A; CCKBR; GABRR1; GRIA3A; CHRNA5
Glutamatergic synapse
GNG11; Adcy4; PPP3CB; GNB1; PRKCA; PLA2G4D; PRKACB; ITPR1; GRIA3; GNG4

Protein Function

GRIK3 has several biochemical functions, for example, adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, extracellular-glutamate-gated ion channel activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK3 itself. We selected most functions GRIK3 had, and list some proteins which have the same functions with GRIK3. You can find most of the proteins on our site.
Function
Related Protein
Function adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
Related Protein GRIK3
Function extracellular-glutamate-gated ion channel activity
Related Protein GRIA1A; GRIN3A; GRIN3B; GRIA2; GRIK5; GRIK2; GRIA3B; GRIK3; GRIK4; GRIN2BB
Function glutamate receptor activity
Related Protein GRIK3; GRIA1; GRM3; GRM6; GRID2; GRM2; GRIK5; GRM7; GRM5; GRM1
Function ion channel activity
Related Protein SCN8AA; DDX1; TRPC4B; TRPN1; P2RX8; CHRNA1; GRIA4B; TRPM1B; TRPM1A; KCNF1A
Function ionotropic glutamate receptor activity
Related Protein GRIN3B; GRIK3; KBP; GRIA2A; GRIN1B; GRID2; GRIA2B; GRIN1A; GRIA4B; GRIA1A
Function kainate selective glutamate receptor activity
Related Protein GRIK1; GRIK3; GRIK4; GRIK5; GRIK2
Function protein binding
Related Protein SERBP1; WBP1; PDLIM2; TMEM194; WDR74; BBS1; ENO1; FGB; HSPA1L; ATG4A
Function receptor activity
Related Protein RAMP3; NOTCH4; GFRA1B; LDLR; ADIPOR2; NLGN4X; AMHR2; VMN1R49; NOTCH2; NOTCH1B

GRIK3 Related Articles

Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).
Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).