HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ARRB2A,KIF5B,CHMP7,CXCR4B,GRK1,CHMP2A,PLD2,RAB11FIP5,RAB11FIP1,SH3GL3A |
| Viral carcinogenesis | RBL1,HIST1H2BE,TRADD,RHOA,IRF3,HLA-A,HIST2H4,HIST1H2BQ,MAPK1,H2BFWT |
| Herpes simplex infection | FASLG,SKP1,IKBKB,DAXX,MYD88,MHC2A,TAF13,CD74A,IFNA13,C1QBP |
| Epstein-Barr virus infection | PRKACB,IRAK1,PSMC5,POLR3K,SPI1,HSPA6,CD19,HSPA8,TBPL2,EIF2AK3 |
| Allograft rejection | H2-AA,HLA-E,HLA-DMB,H2-Q10,HLA-DRB3,IL10,HLA-DRB4,HLA-DPA1,H2-AB1,HLA-DRB5 |
| Cell adhesion molecules (CAMs) | ITGA6,BLA,CLDNE,NCAM1A,NRCAM,ESAM,ITGB7,CLDN16,ICOSLG,ITGAL |
| Autoi | HLA-A,TPO,HLA-DQB1,CD40,GZMB,HLA-DQA2,HLA-B,HLA-G,HLA-DRA,IFNA4 |
| ne thyroid disease | FASLG,IFNA2,HLA-B,Il2,IFNA4,CD86,IFNA16,CD80,CD40,IFNA13 |
| Graft-versus-host disease | HLA-DMA,HLA-DRA,HLA-DPA1,KIR2DL3,HLA-DOB,IL1A,HLA-G,HLA-DMB,HLA-DQA2,GZMB |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP1,TAPBP,TAP2 |
| receptor binding | PDGFRB,CRTAM,PLA2G1B,LTA,CD70,FGG,SRMS,GLA,PLAUR,RARRES2 |
| TAP2 binding | TAP1,TAPBP |
| peptide antigen binding | HLA-DPB1,DHCR24,H2-AB1,TAPBP,HLA-DRB3,BF2,HLA-B,TUBB3,H2-Q10,HLA-DRB5 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
