HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-DRB5,HSPA1B,HSP90AB1,HLA-DQA2,CANX,IFNG,HLA-DQA1,TNF,HSPA1A,HLA-DQB1 |
| Allograft rejection | IL12B,HLA-DRB5,HLA-DOB,CD28,HLA-A,CD86,HLA-DOA,HLA-DRB3,HLA-C,FASLG |
| Herpes simplex infection | CSNK2A2A,ARNTL1B,IFNA7,IFNA8,ABCB3L1,TNFSF14,TLR2-1,HLA-DRB3,C3A.1,PKZ |
| Graft-versus-host disease | IL1B,HLA-DMB,FASLG,HLA-E,HLA-DQA2,CD80,KLRC1,Il2,HLA-G,H2-AB1 |
| Epstein-Barr virus infection | TAB1,HLA-DRB4,POLR2K,PLCG2,HDAC5,CSNK2B,ENTPD8,POLR2J2,POLR3GL,POLR3B |
| Type I diabetes mellitus | PTPRN2,IFNG,IL1A,HLA-B,H2-AB1,CPE,Fasl,HLA-C,HLA-E,HLA-DRB3 |
| ne thyroid disease | IFNA7,IFNA5,HLA-C,IFNA12,TSHB,H2-Q10,TSHR,IL4,IFNA21,HLA-DOB |
| Autoi | HLA-DQA2,IFNA2,HLA-G,HLA-B,TG,FASLG,CD28,IFNA16,HLA-A,HLA-DRB4 |
| Viral carcinogenesis | HDAC11,CREB3L3,HIST3H2BB-PS,PIK3CA,BAK1,HIST1H4D,SCRIB,H2-Q10,HIST1H4M,CCNE2 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP2,TAPBP,TAP1 |
| TAP2 binding | TAPBP,TAP1 |
| peptide antigen binding | MHC1UJA,MHC1ZDA,MHC1ZHA,MAML1,HLA-DRB5,HLA-DRA,MHC1UBA,HLA-C,TUBB3,TRGV3 |
| receptor binding | ACOT2,TNFSF15,Icosl,Artn,KNG1,TRDN,INSL3,FGF10A,WNT2BB,TNFSF9 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
