HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Graft-versus-host disease | IL1B,KIR2DL1,HLA-DMA,KIR2DL3,HLA-DPA1,FASLG,HLA-DRB3,HLA-B,IL1A,HLA-DRA |
| ne thyroid disease | CD80,HLA-DMA,IL5,HLA-DRB5,IL4,TSHR,IFNA2,HLA-DOA,HLA-DQB1,Ifna15 |
| Cell adhesion molecules (CAMs) | ICAM2,NLGN4X,PTPRFB,PVRL1,PVRL1B,ALCAMA,ITGB2L,NEO1A,LRRC4,MHC2DAB |
| Herpes simplex infection | PVRL2,BMA2,C3,STAT1B,RELA,CDK1,NFKBIB,IL12BA,OAS1B,TRAF1 |
| Phagosome | MRC2,ATP6V1G1,HLA-C,THBS4A,FCAR,BLB2,ATP6V1B1,ACTB1,HLA-B,LAMP1 |
| HTLV-I infection | SFPI1,WNT9B,ANAPC5,ANAPC11,XPO1,CREM,MSX1,CANX,HLA-DRB3,NRP1 |
| Antigen processing and presentation | TAP2,KIR2DS4,CD8B,H2-AB1,PDIA3,CD74,Ctsl,KLRC2,KIR3DL2,HLA-DPB1 |
| Autoi | FAS,Fasl,IFNA13,HLA-DOA,IFNA1,HLA-DRB3,IL5,TPO,HLA-DQA1,FASLG |
| Viral myocarditis | SGCB,SGCD,CD28,PRF1,HLA-E,H2-AB1,H2-Q10,HLA-DQA1,BID,HLA-DRB3 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP2 binding | TAP1,TAPBP |
| receptor binding | NRG2B,NCK1,FGF12B,AMN,LYN,TDGF1,ARPP19,F7,HAO1,CADM4 |
| peptide antigen binding | MHC1UDA,CD209,HLA-DRB5,MHC1UKA,HLA-DQA1,MHC1UXA2,MHC1ZHA,HLA-G,HLA-B,H2-AB1 |
| TAP1 binding | TAPBP,TAP1,TAP2 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
