HLA-F
-
Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | CDK1,HLA-DRB5,HDAC1,PRKACA,PSMC5,YWHAE,PSMC4,PSMC2,HLA-A,HLA-DRB4 |
| HTLV-I infection | NFATC3,MYBL2,WNT16,FZD9,NFATC2,FOS,CDC27,WNT9A,DVL3,TRP53INP1 |
| Viral myocarditis | HLA-C,ICAM1,CASP8,ACTG1,HLA-DRB4,HLA-DOB,CD86,BID,HLA-B,ITGAL |
| ne thyroid disease | IFNA12,Ifna15,HLA-DRB5,IFNA10,IFNA21,HLA-DRB3,HLA-DMA,GZMB,FASLG,HLA-B |
| Phagosome | CD209B,RAB5AA,TUBB2B,TFRC,SFTPA1,MBL1,TUBA1L2,SEC22BB,DYNC2H1,OLR1 |
| Graft-versus-host disease | HLA-DPA1,IL1A,IL6,FAS,KIR3DL2,HLA-DQA1,IFNG,GZMB,HLA-DRA,KIR2DL1 |
| Antigen processing and presentation | HSPA1L,HLA-DQB1,IFI30,TAP2,HLA-DPA1,KIR2DS3,KIR2DL1,KIR2DS5,Ctsl,KIR2DL3 |
| Autoi | HLA-DOB,Fasl,HLA-DPA1,HLA-G,TSHR,Il2,IFNA10,FAS,IFNA12,H2-AB1 |
| Herpes simplex infection | TRP53,CSNK2A2A,HLA-B,CLOCK,PPP1CBL,Ccl12,IFNA5,SRSF7,BF1,NFKBIA |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAPBP,TAP1,TAP2 |
| peptide antigen binding | HLA-DRA,HLA-G,MR1,HLA-DPB1,HLA-B,MHC1ZHA,MAML1,H2-Q10,MHC1UEA,HLA-A |
| receptor binding | CROT,EDN3,IL1RAPL1,IDUA,ABL1,GDNF,LGI1,HSPA1A,UTS2,FGF8A |
| TAP2 binding | TAPBP,TAP1 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
Resources
Gene Families
Related Services
Related Products
References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
