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HLA-F

Official Full Name

major histocompatibility complex, class I, F
Overview

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Synonyms

HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-F-239H	Recombinant Human HLA-F, His-tagged	E.coli	His	22-305aa	Inquiry
Human	HLA-F-331HCL	Recombinant Human HLA-F lysate	HEK293	N/A		Inquiry
Human	HLA-F-3439H	Recombinant Human HLA-F protein, His-tagged	E.coli	His	21-298 aa	$319 / 25ug

Involved Pathway
Protein Function
Interacting Protein
HLA-F Related Articles
HLA-F Related Gene Family

HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	PIP5K1BA;VPS37D;CDC42;CAV3;ERBB3A;MVB12BA;TFR1A;CYTH3;CHMP4A
Phagosome	ATP6V1A;TUBA3E;TUBA4L;CTSLA;TFR1A;HLA-DRB5;HLA-DRB1;OLR1;TUBA2
Cell adhesion molecules (CAMs)	CLDNJ;CLDN10;CLDNA;JAM3B;CLDN8;NRXN2;CADM3;CADM1;CLDNH
Antigen processing and presentation	HSPA6;HLA-B;HSPA1L;RFX5;CD8A;KLRC1;H2-Q10;KLRC4;HSPA1A
Type I diabetes mellitus	HLA-DRA;HLA-A;IL1A;HLA-DQB1;GAD1;FASLG;FAS;HSPD1;HLA-DRB5
HTLV-I infection	MSX2;Pdgfa&Pdgfb;KAT2B;TERT;Il2;ETS2;CDC27;PRKACG;NFKBIA
Herpes simplex infection	TAF5L;Ifna15;MAPK9;HLA-DRB4;SRSF4;SRSF9;MHC2DAB;IFIH1;HLA-DRB3
Epstein-Barr virus infection	MDM2;ENTPD1;IL10RB;MAPK10;MAP2K4;EIF2AK4;PLCG2;EIF2AK3;NEDD4
Viral carcinogenesis	MAPKAPK2;HIST1H4N;GTF2B;YWHAG;C3;PIK3R5;TTC6;YWHAE;NFKBIA
Autoi	FASLG;CD28;H2-AA;Il2;IFNA1;HLA-DRA;CD40LG;HLA-F;Ifna15
ne thyroid disease	HLA-A;IFNA7;CD40LG;CD28;HLA-DOA;IFNA4;IFNA6;HLA-DQB1;CD86
Allograft rejection	HLA-DRB4;CD40LG;FAS;HLA-DPA1;IL12A;HLA-DRB1;CD86;HLA-DMA;HLA-DQB1
Graft-versus-host disease	HLA-DMA;CD86;TNF;IFNG;HLA-DPA1;PRF1;HLA-DQA1;IL6;HLA-DRA
Viral myocarditis	SGCB;CAV1;ITGAL;ABL1;HLA-C;BID;HLA-DQA1;RAC1;SGCA

HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

Function	Related Protein
TAP1 binding	TAPBP;TAP2;TAP1;HLA-F
TAP2 binding	TAP1;HLA-F;TAPBP
peptide antigen binding	CLEC4M;MHC1ZFA;MHC1ZE;TUBB3;HLA-DRB3;TAP1;AZGP1;MHC1UIA;HLA-G
receptor binding	F7;NPFF;ANXA1;IFNL3;CHRNA10;MTSS1;LRP6;NPPC;NPY

HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

q81nr7_bacan; ilvD

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).

Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).