HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | FAM49BA,ITGB1B.2,THBS1,CTSL1B,THBS3,HLA-C,FCGR3,TUBA1L,CANX,TLR4BA |
| Viral myocarditis | SGCD,CD40LG,CASP8,RAC2,HLA-B,ABL1,HLA-DMB,HLA-C,CCND1,CAV1 |
| Viral carcinogenesis | HDAC8,HIST1H4N,CCNE2,HDAC11,NFKB1,HIST2H4A,HIST1H4C,IRF3,DNAJA3,HNRNPK |
| Endocytosis | CSF1RA,ERBB3B,TGFB1A,H2-Q10,GRK5,ASAP2A,HSPA1B,SNX1,VPS25,MHC1UXA2 |
| Autoi | HLA-DRB3,PRF1,HLA-DRB4,FAS,CD40,IFNA13,Ifna15,HLA-DPB1,IFNA5,IL5 |
| Epstein-Barr virus infection | TRAF5,POLR2I,PRKACA,PSMC4,POLR3H,TRAF3,ENTPD1,NFKBIE,EIF2AK3,RBPJL |
| ne thyroid disease | CD40,IFNA12,IFNA17,H2-Q10,HLA-DRB4,FAS,Ifna15,TPO,HLA-DMB,HLA-DRB5 |
| Antigen processing and presentation | HLA-DRB5,CD74,HSP90AB1,HLA-DQA2,NFYA,NFYC,HLA-A,CANX,HLA-C,HLA-DRB3 |
| HTLV-I infection | IL6,GM-CSF,HLA-B,KRAS,TSPO,CDC26,IL15,ICAM1,CCND2,HLA-E |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP2,TAPBP,TAP1 |
| receptor binding | ANG,JAK2,FYNA,HRG,FGF8A,SLC9A3R1,CCDC129,YES1,WNT7AA,NPFF |
| peptide antigen binding | HLA-DRB5,HLA-B,MHC1ZHA,MHC1UHA,AZGP1,TRGV3,CD209,HLA-DQA1,H2-AA,HLA-DQB1 |
| TAP2 binding | TAPBP,TAP1 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
