HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral myocarditis | EIF4G2,ABL2,CAV1,ICAM1,HLA-DRB4,ITGB2L,CD40LG,HLA-DQB1,HLA-DQA1,SGCB |
| HTLV-I infection | IL1R2,ATM,NFKB2,Adcy4,WNT3,HLA-DRB4,BCL2L1,WNT9A,KAT2B,HLA-DMB |
| Endocytosis | MVB12BA,SNX2,ASAP2B,TSG101A,GRK7B,TFR1A,SMURF1,SPG20A,NEDD4,ACAP1 |
| Viral carcinogenesis | CDK1,HDAC7,PIK3CG,HIST1H4F,RBPJ,HIST1H2BH,NFKB1,HIST1H2BL,CREB5,HLA-G |
| Herpes simplex infection | CUL1A,MED8,NFKBIAB,IFNG1-2,CLOCK,H2-AB1,BF1,ARNTL,TRP53,HLA-DPB1 |
| Graft-versus-host disease | HLA-DRA,HLA-C,HLA-DRB1,IL1A,CD80,CD86,FASLG,FAS,HLA-DRB4,IL6 |
| Antigen processing and presentation | HLA-DOB,IFNG,TAP2,HLA-A,HSPA2,HLA-DQB1,CTSB,KLRC2,CTSS,HLA-DPA1 |
| Type I diabetes mellitus | HLA-G,HLA-C,FASLG,HLA-DQB1,CPE,PRF1,IL1B,HLA-DPB1,HLA-DMB,FAS |
| Autoi | IFNA4,HLA-DOA,Ifna15,IFNA10,HLA-DRA,Fasl,HLA-E,HLA-DMB,H2-AB1,HLA-B |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP1,TAP2,TAPBP |
| TAP2 binding | TAPBP,TAP1 |
| peptide antigen binding | H2-AB1,HLA-DQB1,MHC1ZDA,MHC1UXA2,MHC1ZHA,MHC1ZBA,MHC1UJA,HLA-DRB3,MR1,HLA-G |
| receptor binding | WNT11R,HILPDA,NMU,KNG1,SMARCD3,RARA,JAK2,AMN,BAAT,P2RX4 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
