HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | BF2,CADM3,CD34,CD22,CLDN11A,NRXN3,NLGN4A,NLGN1,CLDN14,CLDN10A |
| Viral myocarditis | CYCS,SGCG,CXADR,HLA-A,HLA-DQB1,BID,LAMA2,SGCA,RAC3,ICAM1 |
| Endocytosis | RNF41,SMAD3A,VPS37D,HSPA6,RAB35B,ARR3B,SNX3,ARF3B,HSP70,TGFB1A |
| Autoi | IL5,CD40LG,Fasl,IFNA13,H2-AB1,IFNA17,IFNA4,HLA-DRB3,CD28,HLA-DOA |
| Allograft rejection | HLA-DRB3,CD86,CD28,HLA-DQA1,CD40LG,IL12B,IFNG,IL12A,HLA-C,HLA-E |
| ne thyroid disease | H2-Q10,Il2,PRF1,HLA-DOA,HLA-DRB1,HLA-DPA1,HLA-DQA2,CD28,HLA-C,IFNA8 |
| Phagosome | THBS3,FCGR3B,HLA-DOB,MHC2DEB,ITGAM,TUBA8L,HLA-DRB3,FCGR1,HLA-E,C1R |
| Herpes simplex infection | TBPL2,SRSF3,BLB1,SRPK1B,CDK1,FAS,PPP1CAA,PVRL1B,TAF13,IL12B |
| Epstein-Barr virus infection | RBPJ,HDAC4,IRAK1,IL10RB,CR2,NFKBIB,CCNA1,POLR3G,MDM2,TBPL2 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1UXA2,HLA-DRB1,MAML1,HLA-DRB5,MHC1UBA,MHC1ZDA,MHC1ZE,HLA-B,MHC1UDA,MHC1UFA |
| receptor binding | NRG2B,CXCL1,HAND2,DIAPH1,REN,CADM2,SMAGP,TNFSF12,LGI1,CADM1B |
| TAP1 binding | TAPBP,TAP2,TAP1 |
| TAP2 binding | TAPBP,TAP1 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
