HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Autoi | IFNA12,HLA-B,HLA-G,TG,IFNA2,IFNA5,GZMB,HLA-DQA2,IFNA16,FAS |
| Herpes simplex infection | CDC34A,ABCB3L1,IFNGR2,BLB2,TAB2,TTC6,C3A.1,SRSF3,IKBKB,IFNA1 |
| Type I diabetes mellitus | HLA-DMB,PTPRN2,GZMB,HSPD1,GAD1,CD86,HLA-DPB1,Fasl,INS,H2-AA |
| Epstein-Barr virus infection | IL10RB,EIF2AK2,GTF2E2,RELB,HSPA6,FGR,HLA-DPB1,TBP,HDAC5,GTF2E1 |
| Endocytosis | SMAD2,MET,CYTH4,IL2RA,CHMP6B,ARPC5LB,ARAP2,ADRB1,ARF6,DAB2 |
| Antigen processing and presentation | HLA-DQA2,LGMN,IFI30,HLA-C,HLA-DPA1,PSME2,CD4,CD8A,IFNG,HSPA4 |
| Allograft rejection | HLA-C,HLA-A,IFNG,HLA-B,H2-AB1,H2-AA,MICA,HLA-DRA,HLA-G,HLA-DMB |
| Cell adhesion molecules (CAMs) | CLDN8,ITGA6,NRCAM,H2-AA,SDC1,ITGB1B.2,HLA-DRB5,MHC2DAB,CLDN5A,CD8B |
| Graft-versus-host disease | KIR3DL2,HLA-DPB1,HLA-C,HLA-G,KIR2DL1,HLA-DMB,HLA-A,HLA-DQA1,CD28,Fasl |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1UIA,BF2,MHC1ZE,MHC1UJA,MAML1,TRGV3,MHC1ZFA,MHC1UKA,MHC1UFA,HLA-DRB3 |
| TAP1 binding | TAP2,TAPBP,TAP1 |
| TAP2 binding | TAPBP,TAP1 |
| receptor binding | ICOSLG,AGXT,ACOT2,KNG1,ANG,MIF,TESPA1,EDN3,INSL4,ARPP19A |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
