HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | HLA-A,FCGR1A,NCF1,THBS4B,TUBB,ATP6V0A4,BLA,ITGB5,SFTPD,FCGR3A |
| Allograft rejection | HLA-DQA1,CD28,HLA-DRB1,HLA-DMB,HLA-DMA,H2-Q10,TNF,Fasl,HLA-DOB,Il2 |
| ne thyroid disease | IFNA14,HLA-A,HLA-DPB1,HLA-DMA,TSHR,HLA-DMB,IFNA17,HLA-B,IFNA5,CD40 |
| Viral carcinogenesis | TRADD,HIST1H2BL,RHOA,HDAC1,HDAC3,MAPK1,Casp3,PRKACG,HDAC11,EGR3 |
| Epstein-Barr virus infection | POLR2J2,IKBKB,EIF2AK4,POLR2E,Fcer2a,PIK3R1,RIPK1,GTF2E1,MAPK8,PSMD13 |
| Cell adhesion molecules (CAMs) | VCAN,HLA-DRB1,CNTNAP2,CADM1A,CNTN1A,PVRL3B,SELP,F11R,PVRL1,NTNG1 |
| Endocytosis | RET,KIF5A,ARPC4,PSD,PML,CHMP2B,TGFBR1A,EPS15,RAB11FIP5,WIPF2B |
| Herpes simplex infection | IFNA6,IFNA17,STAT1,MHC2DAB,STAT1A,NXF1,PPP1CB,BF1,TAP2,MAVS |
| Type I diabetes mellitus | IL1B,INS2,CD86,HLA-DQA2,CPE,HLA-DQA1,Il2,LTA,PRF1,GZMB |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAP1,TAPBP,TAP2 |
| peptide antigen binding | MHC1ZFA,MHC1UHA,BF2,MHC1UXA2,MHC1UBA,HLA-DRA,HLA-DRB1,MHC1UFA,HLA-E,HLA-DRB4 |
| TAP2 binding | TAP1,TAPBP |
| receptor binding | PLG,AGRP2,IL29,RIPK2,GNPAT,LYN,HAO2,FGF10A,Icosl,GFRA3 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
