hla-f
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  • Official Full Name
  • major histocompatibility complex, class I, F
  • Background
  • This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms
  • HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12
Cat.#:HLA-F-239HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HLA-F, His-tagged
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Cat.#:HLA-F-331HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human HLA-F lysate
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Involved Pathway

HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
CYTH1B; ARRB2; CAPZA3; LDLRAP1A; EHD2; ADRB2A; ADRB2B; CXCR4A; EPN3; RNF103-CHMP3
Phagosome
C1R; DYNC1I2A; C3A.2; BLB1; TUBA3C; H2-AA; THBS4A; TFR1A; TUBB; NCF4
Cell adhesion molecules (CAMs)
CLDN8; NRCAM; CD274; CD8A; NEO1A; MHC2DAB; NEGR1; F11R; CDH1; ICOS
Antigen processing and presentation
HSPA2; HSP90AA1; TAPBP; RFX5; CALR; H2-Q10; HLA-E; CD8B; CTSL1; KIR3DL1
Type I diabetes mellitus
TNF; PRF1; H2-AB1; GAD2; IL12B; HLA-G; HLA-DRB1; FAS; ICA1; CD28
HTLV-I infection
STAT5B; HLA-E; EP300; SLC25A31; HLA-G; MYBL2; PIK3R3; WNT1; WNT3; Fzd4
Herpes simplex infection
POU2F3; MAPK10; SRSF5; IL12B; CUL1; SRSF7; CLOCKA; TP53; MAP3K7; SOCS3B
Epstein-Barr virus infection
CD44; PRKACB; RBPJL; SFPI1; CR2; HLA-E; GTF2B; HLA-DRA; MAP3K7; TRAF6
Viral carcinogenesis
HIST1H2BD; PSMC1; TBP; MAPK1; POLB; TRAF1; TRAF5; HIST1H2BJ; CCNE2; PIK3R5
Autoi
IFNA10; HLA-B; HLA-E; HLA-C; GZMB; IFNA21; Ifna15; CD80; H2-AA; IFNA17
ne thyroid disease
Fasl; PRF1; IFNA13; GZMB; IL5; HLA-DOA; TPO; IFNA4; IFNA2; FAS
Allograft rejection
IL10; IFNG; TNF; HLA-DOA; FAS; HLA-DPA1; IL5; CD40; HLA-B; HLA-DRB1
Graft-versus-host disease
KIR3DL1; HLA-B; PRF1; CD86; Il2; HLA-DOB; FASLG; HLA-DMA; HLA-E; HLA-DPA1
Viral myocarditis
RAC3; H2-Q10; HLA-DRB3; HLA-DQA1; SGCD; CASP8; HLA-DRB4; ITGB2L; SGCG; ABL1

Protein Function

HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
Function
Related Protein
Function TAP1 binding
Related Protein TAP2; HLA-F; TAPBP; TAP1
Function TAP2 binding
Related Protein TAP1; TAPBP; HLA-F
Function peptide antigen binding
Related Protein TRGV3; HLA-F; MHC1ZE; HLA-B; H2-AA; TAP1; MHC1UBA; AZGP1; MR1; MHC1UJA
Function receptor binding
Related Protein DDO; IDUA; HMGCL; GNPAT; TNFSF13B; IDE; ACOX1; CHRNA10; ENSA; GNB2L1

Interacting Protein

HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan; ilvD

HLA-F Related Articles

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

HLA-F Related Gene Family

Immunoglobulins