HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Allograft rejection | H2-AA,TNF,IL5,HLA-DOB,HLA-DQA1,IFNG,HLA-DRB3,CD28,IL10,HLA-DOA |
| Autoi | IL5,HLA-DOB,HLA-DRB5,IFNA13,HLA-DPA1,IFNA6,TPO,FAS,TSHB,Ifna11 |
| Graft-versus-host disease | KIR2DL3,HLA-DQA2,H2-Q10,HLA-DQA1,HLA-DRA,HLA-DPA1,HLA-DRB5,KLRC1,HLA-DRB1,HLA-DRB3 |
| Cell adhesion molecules (CAMs) | HLA-DRB4,CLDNB,MHC2DCB,ICAM2,CD40LG,PVRL2,PTPRFB,BLA,OCLN,PTPRC |
| Endocytosis | ARPC5L,FMNL3,CHMP2BA,GRK1,ADRB1,TGFBR2,DNM3,BF2,CYTH4,CAPZA2 |
| Herpes simplex infection | HLA-DPA1,SRSF7A,HLA-DQA1,PILRA,MHC1UXA2,HCFC2,CASP3B,BF1,IFNA12,TRAF2 |
| Type I diabetes mellitus | PTPRN2,PTPRN,GAD1,HLA-DMB,HLA-C,Il2,TNF,HLA-DOA,HLA-DRB3,HLA-DRB4 |
| Antigen processing and presentation | CTSL1,HSPA8,HLA-DOA,RFXANK,HSPA5,HLA-DQA2,CALR,HLA-DPA1,Ctsl,KIR2DL3 |
| Phagosome | Itgam&Itgb2,Cd209g,HLA-G,RAB5AA,STX12,TLR4,TUBA1B,ITGA5,RAB7A,CTSSB.1 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAPBP,TAP2,TAP1 |
| receptor binding | EDA,DDO,HCST,RARA,LPL,CADM3,NRTN,NRG4,CSK,HFE2 |
| peptide antigen binding | TRGV3,CD209,MAML1,HLA-DQA1,BF2,HLA-DRB3,MHC1UDA,CLEC4M,HLA-DQB1,MHC1UKA |
| TAP2 binding | TAP1,TAPBP |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
