HLA-F

  • Official Full Name

    major histocompatibility complex, class I, F
  • Overview

    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms

    HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli Human His 21-298 aa
HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli Human His 22-305aa
HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 Human Non

    Involved Pathway

    HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Type I diabetes mellitus HLA-DOB,HLA-DRB3,CD28,H2-Q10,HLA-DMA,INS2,CD80,HLA-DOA,HLA-DRB5,INS
    Cell adhesion molecules (CAMs) HLA-A,SDC4,SDC1,VTCN1,CLDN10,NLGN4X,NFASCA,SPN,CLDN15LB,CTLA4
    ne thyroid disease IFNA10,IFNA8,HLA-DMA,TSHR,HLA-G,Il2,HLA-DMB,IFNA1,TG,FAS
    Phagosome ATP6V1AA,TLR2,CD14,ATP6V0D1,FCGR4,TUBA4A,Cd209g,CALRL2,SEC22B,RAC1B
    HTLV-I infection WNT5A,CDC27,SPI1,HLA-DQB1,ETS1,POLE2,DVL3,SRF,PIK3R1,FZD9
    Autoi FASLG,HLA-DRB5,FAS,GZMB,H2-AA,HLA-DRB3,TSHB,IFNA8,HLA-DOA,CD40
    Viral myocarditis ABL2,H2-AA,PRF1,HLA-DQA2,ITGAL,CASP9,HLA-DOA,CD86,SGCB,MYH7
    Endocytosis PIP5K1BA,PSD2,SMURF1,FGFR4,CHMP4B,ITCH,CAPZA1,ARPC4L,DNM2,ARF5
    Graft-versus-host disease IL1B,HLA-DRB4,HLA-DOA,HLA-C,H2-AB1,HLA-DRB5,HLA-DQA2,KIR3DL2,IL6,HLA-DRB3

    Protein Function

    HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

    Function Related Protein
    TAP2 binding TAPBP,TAP1
    receptor binding ACOT2,GFRA3,PPP2R4,PANX1,DDO,PTK2AB,GSTK1,APOF,HAO1,GCG
    peptide antigen binding HLA-B,MHC1UEA,MHC1UIA,AZGP1,HLA-DPA1,MHC1UBA,H2-Q10,TAPBP,TAP1,CD209
    TAP1 binding TAPBP,TAP2,TAP1

    Interacting Protein

    HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

    q81nr7_bacan;ilvD

    Resources

    References

    • Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    • Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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