HLA-F

  • Official Full Name

    major histocompatibility complex, class I, F
  • Overview

    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms

    HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli Human His 21-298 aa
HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli Human His 22-305aa
HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 Human Non

    Involved Pathway

    HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HTLV-I infection EP300,Fzd4,IL6,IKBKB,APC,PPP3CB,CD3D,FZD8,H2-AB1,CCND2
    Type I diabetes mellitus HLA-A,ICA1,FASLG,CPE,CD28,HLA-DMB,INS,PRF1,IL12A,LTA
    Autoi CD28,IFNA6,HLA-DOA,H2-AA,FASLG,TSHB,Il2,IFNA2,TG,IFNA14
    Antigen processing and presentation H2-AB1,IFNG,HLA-DOA,PSME2,HLA-E,HLA-DMB,NFYB,HSP90AB1,HSPA8,CD8A
    ne thyroid disease IFNA13,IFNA14,Il2,HLA-G,TPO,IFNA7,TSHR,HLA-DMB,CD28,CD80
    Viral carcinogenesis RANBP1,CCND2,CDK1,SCIN,GTF2H2C,LTBR,PIK3R2,HIST2H4A,PIK3CB,PKM
    Endocytosis TGFB2,CHMP6B,CAPZA1B,SMURF1,DNM2B,PARD6B,RHOAA,BIN1,CAV2,ADRB3
    Phagosome ATP6V0D2,TUBA8L3,HGS,FCGR3,THBS4B,ATP6V0E1,HLA-DQB1,ITGB1A,ATP6V1C2,TUBA1L2
    Allograft rejection FASLG,H2-AB1,IL12A,HLA-DRB4,HLA-DRB3,IL10,TNF,HLA-DQB1,HLA-DPB1,IFNG

    Protein Function

    HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding HLA-B,MHC1ZKA,CLEC4M,MHC1UHA,TUBB3,MR1,HLA-DRB5,HLA-DRA,TAPBP,HLA-DRB1
    TAP1 binding TAP2,TAPBP,TAP1
    receptor binding CXCL10,SELPLG,UCN2,SCP2,PTK2B,DHRS4,ABL1,TRDN,CD72,GNB2L1
    TAP2 binding TAPBP,TAP1

    Interacting Protein

    HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

    q81nr7_bacan;ilvD

    Resources

    References

    • Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    • Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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