HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | HLA-C,PIK3R3,SYK,VDAC3,MAD1L1,HIST1H2BJ,HNRNPK,RBL1,HIST1H4A,HIST1H2BD |
| Phagosome | TUBA7L,RAB7A,STX12,ACTB,ATP6V0C,HLA-DRB4,FCGR1A,ITGB2,HLA-C,TUBB2A |
| Viral myocarditis | CD86,HLA-DQB1,HLA-DRA,CD80,SGCB,ABL2,CD40,SGCG,RAC1,SGCD |
| HTLV-I infection | ATF3,NFATC1,CDC23,HLA-DQB1,MYB,TGFBR1,POLD2,HLA-DRB5,XIAP,RANBP1 |
| Type I diabetes mellitus | Fasl,INS,HLA-DQA1,CPE,HLA-B,IL12A,GZMB,HLA-DRB4,INS1,IL1B |
| Epstein-Barr virus infection | HLA-DQA1,PSMC5,NFKBIB,TNFAIP3,SKP2,MAPK9,POLR3F,IL10RA,HSPA2,TRAF6 |
| Antigen processing and presentation | HLA-DRB1,KIR2DS5,HLA-B,HSPA5,HLA-DRA,HLA-E,HLA-C,NFYA,PDIA3,HSPA1L |
| Autoi | HLA-DRA,CD40LG,PRF1,H2-AA,CD86,HLA-DRB5,IFNA4,IFNA14,IL5,H2-Q10 |
| Allograft rejection | HLA-DQB1,HLA-DRB5,H2-AB1,HLA-DRB3,HLA-DRB1,HLA-C,Il2,HLA-DRB4,CD80,TNF |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | MHC1ZDA,MHC1ZKA,MHC1UXA2,HLA-B,HLA-DRB1,MAML1,HLA-DRB4,H2-AA,MHC1ZBA,H2-AB1 |
| TAP2 binding | TAPBP,TAP1 |
| TAP1 binding | TAP2,TAP1,TAPBP |
| receptor binding | HRG,CCL2,MLN,NRTN,NTF7,HACL1,RASA1,CADM4,TNFSF13,FGF10A |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
