HLA-F
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Official Full Name
major histocompatibility complex, class I, F
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Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | His | 22-305aa | |
Human | HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | N/A | ||
Human | HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | His | 21-298 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-F Related Articles
- HLA-F Related Gene Family
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | ARPC5A;PML;CAV3;ARFGEF1;RAB11FIP3;SRC;RAB11FIP2;IL2RB;H2-Q10 |
Phagosome | TUBA1L;BMA2;MHC2DAB;FAM49BA;TLR4;MHC2DCB;HLA-DMB;TUBAL3;PIKFYVE |
Cell adhesion molecules (CAMs) | CADM1B;MHC1UEA;NEGR1;CLDN3;PECAM1;CLDN5;CD28;CLDN19;BF1 |
Antigen processing and presentation | KIR2DS2;HLA-DOB;HSPA4;HLA-B;KIR3DL2;CD8B1;KIR2DS5;HSP90AA1;KLRC2 |
Type I diabetes mellitus | HLA-A;CD86;HLA-E;IL1B;GAD1;HLA-DQB1;H2-Q10;HLA-DMA;INS |
HTLV-I infection | RANBP1;DVL3;PPP3CA;ELK1;WNT8A;FZD6;APC2;FZD5;MAP2K4 |
Herpes simplex infection | IFNA12;JAK2A;NFKBIA;PER1A;MHC1UEA;OAS1;POLR2A;HLA-DPA1;SP100 |
Epstein-Barr virus infection | PTMA;HSPB1;HDAC5;PSMD2;PSMD7;PIK3CB;DDX58;ENTPD3;PIK3R5 |
Viral carcinogenesis | HIST1H2BA;BAK1;HIST1H2BK;TRAF5;HIST1H4N;CREB3L1;HIST1H4G;HIST1H2BG;VAC14 |
Autoi | CD40LG;HLA-DRB5;CD86;IFNA12;HLA-DPA1;IFNA4;HLA-DPB1;IFNA7;H2-AB1 |
ne thyroid disease | HLA-A;HLA-DQA1;Ifna11;HLA-DRB3;IFNA16;CD40LG;IFNA13;HLA-DQA2;HLA-DRB4 |
Allograft rejection | CD28;HLA-DRB3;HLA-DRB4;HLA-DRB5;PRF1;HLA-F;HLA-DQB1;HLA-DMB;IL10 |
Graft-versus-host disease | HLA-B;HLA-DMB;HLA-G;KIR3DL1;TNF;HLA-DPB1;GZMB;HLA-DOA;KLRC1 |
Viral myocarditis | RAC2;H2-Q10;CD80;HLA-DPA1;HLA-DQA2;EIF4G3;HLA-DPB1;ITGB2;CCND1 |
HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
Function | Related Protein |
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TAP1 binding | TAP2;TAP1;TAPBP;HLA-F |
TAP2 binding | HLA-F;TAPBP;TAP1 |
peptide antigen binding | HLA-C;HLA-DRB1;MHC1UEA;HLA-G;MHC1ZKA;TAPBP;HLA-DRB3;HLA-B;MR1 |
receptor binding | UCN2;MSN;PGR;PLXNC1;HLA-B;IAPP;CADM2;HFE;WNT5B |
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan; ilvD
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