• Official Full Name
  • homeobox C4
  • Background
  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5 non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.
  • Synonyms
  • HOXC4; homeobox C4; homeo box C4 , HOX3, HOX3E; homeobox protein Hox-C4; CP 19; CP19; Homeo box 3E; Homeo box C4; Homeo box protein HoxC4; Homeobox 3E; Homeobox protein CP19; Homeobox protein Hox C4; Homeobox protein Hox-3E; Homeobox protein HoxC4; Homeobox3E; HomeoboxC4; HOX 3; Hox 3E; HOX C4; HOX3; Hox3E; HOXC 4; HXC4_HUMAN; OTTHUMP00000217392; OTTHUMP00000217393
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HOXC4 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HOXC4, GST-tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HOXC4
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HOXC4 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HOXC4 Protein, His-tagged
Source (Host):Species:Human
Product nameRecombinant Human HOXC4 293 Cell Lysate

Protein Function

HOXC4 has several biochemical functions, for example, HMG box domain binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXC4 itself. We selected most functions HOXC4 had, and list some proteins which have the same functions with HOXC4. You can find most of the proteins on our site.
Related Protein
Function HMG box domain binding
Related Protein UTF1; PAX3; DLX5; ALX4; OLIG2; POU3F3; CEBPA; PRRX1; SP1; MEOX1
Function protein binding
Related Protein UNC13B; LEPR; Tnfrsf23; PTTG1; SHARPIN; HILPDA; SMAD5; CD37; PTPN13; DIABLO
Function sequence-specific DNA binding
Related Protein ELK4; FOXG1B; PRDM16; NKX2.4B; NR2F1; ZNF711; HOXD12; POU2F2; NR4A2B; KLF2
Function transcription factor activity, sequence-specific DNA binding
Related Protein SALL1; NR1D1; HOXA3; EVX1; DMRT3A; GATA6; ATF4B1; TCF19; ZNF577; ZFP639

Interacting Protein

HOXC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXC4.

HOXC4 Related Articles

White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).
Zan, H; Casali, P; et al. Regulation of Aicda expression and AID activity. AUTOIMMUNITY 46:83-101(2013).