hspa1l
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  • Official Full Name
  • heat shock 70kDa protein 1-like
  • Background
  • This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.
  • Synonyms
  • HSPA1L; heat shock 70kDa protein 1-like; heat shock 70kD protein like 1; heat shock 70 kDa protein 1-like; HSP70 HOM; hum70t; heat shock 70 kDa protein 1L; heat shock 70kD protein-like 1; heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom; H
Cat.#:HSPA1L-5103HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HSPA1L Protein, GST-tagged
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Cat.#:HSPA1L-13985HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA1L, GST-tagged
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Cat.#:HSPA1L-1452HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HSPA1L protein, His-tagged
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Cat.#:HSPA1L-27084THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human HSPA1L
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Cat.#:Hspa1l-1453RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hspa1l protein, His-tagged
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Cat.#:HSPA1L-2945RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HSPA1L Protein
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Cat.#:HSPA1L-5356HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HSPA1L 293 Cell Lysate
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Involved Pathway

HSPA1L involved in several pathways and played different roles in them. We selected most pathways HSPA1L participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
SMX5; HSPA1A; SNRPE; PRPF40B; LSM7; NHP2L1B; SYF2; TXNL4A; HNRPK; SNRPA1
MAPK signaling pathway
CACNA1SB; FLNA; PPP3R1; RAC2; MYCB; MAP3K11; CD14; DDIT3; PRKACBB; TGFB2
Protein processing in endoplasmic reticulum
RRBP1; UBE2D2; HSPA1L; CAPN2A; HSPBP1; MAPK8; CRYAA; XBP1; WFS1; MAP2K7
Endocytosis
CHMP4B; WIPF1A; SMAP2; CAV1; SRC; ACAP3; CLINT1A; CHMP4A; PML; CBLC
Antigen processing and presentation
KIR2DL3; KLRC1; IFI30; PDIA3; HLA-DRB4; HSP90AB1; H2-Q10; KLRC4; CALR; CTSS
Estrogen signaling pathway
PIK3R1; MAPK3; FKBP4; SRC; HSPA1A; MAP2K1; ITPR1; SHC1; SHC3; CREB3L3
Legionellosis
IL6; TLR5; VCP; CXCL1; CD14; Casp3; MYD88; SAR1A; RAB1; CLK1
Toxoplasmosis
MAPK13; BIRC7; HLA-DQA2; PIK3R5; IRGM; HLA-DRB3; H2-AA; TYK2; AKT2; MAPK3
Measles
IL1B; IFNGR1; FCGR2B; TNFSF10; Ifna11; CD209B; IFNAR1; CCNE2; TNFRSF10D; CD3E
Influenza A
CXCL8; MYD88; PML; IFNA8; CASP9; EIF2AK4; TLR3; Ccl12; CPSF4; DNAJB1
Epstein-Barr virus infection
POLR2L; CD19; POLR2A; MAPK12; TBPL1; HLA-DQA2; NFKBIA; MAP2K3; TBPL2; PSMD12

Protein Function

HSPA1L has several biochemical functions, for example, ATP binding, heat shock protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1L itself. We selected most functions HSPA1L had, and list some proteins which have the same functions with HSPA1L. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MCM4; PRPF4BA; MAP2K4A; ACTR1B; TYK2; ACVRL1; DDX19; PAK1; CSNK1A1; AARS
Function heat shock protein binding
Related Protein KCNJ11; PDXP; DNAJA3A; DNAJC9; NFKB1; HSPA8; PARK2; TOMM34; LIMK1; DNAJB6
Function protein binding
Related Protein RPS15; APTX; NLRP12; ZNF792; ELF3; CD5; SPACA3; FKBP1B; RAB1A; ALS2
Function ubiquitin protein ligase binding
Related Protein PINK1; TCP1; SCN5A; YWHAZ; TRIB3; MUL1; HSPA9; NKD2; UBE2G1; HSPA8
Function unfolded protein binding
Related Protein SPG7; DNAJB2; HSP90AA1.2; HSP26; AHSP; SRSF12; DNAJA3A; CALRL2; LMAN1; SERPINH1

Interacting Protein

HSPA1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1L here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1L.
TP53; TRAF2; MAP3K1; TAB1; NFKB2; NFKBIE; IKBKB; MAP3K7; MAP3K7; RIPK2; TNFRSF1A; NFKB1; TNFRSF1B; NFKBIA; MAP3K8; YWHAZ

HSPA1L Related Articles

Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
Zhang, XM; Tanguay, RM; et al. Variants of HSPA1A in Combination with Plasma Hsp70 and Anti-Hsp70 Antibody Levels Associated with Higher Risk of Acute Coronary Syndrome. CARDIOLOGY 119:57-64(2011).