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INSC

  • Official Full Name

    inscuteable homolog

  • Overview

    In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion;mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling;complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 (PubMed;16458856)).
  • Synonyms

    INSC; inscuteable homolog (Drosophila); protein inscuteable homolog;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INSC-5099H Recombinant Human INSC Protein, GST-tagged Wheat Germ GST
Human INSC-5981HF Recombinant Full Length Human INSC Protein, GST-tagged In Vitro Cell Free System GST 579 amino acids
  • INSC Related Articles

INSC involved in several pathways and played different roles in them. We selected most pathways INSC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INSC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

INSC has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by INSC itself. We selected most functions INSC had, and list some proteins which have the same functions with INSC. You can find most of the proteins on our site.

Function Related Protein

INSC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSC here. Most of them are supplied by our site. Hope this information will be useful for your research of INSC.

Du, QS; Stukenberg, PT; et al. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. NATURE CELL BIOLOGY 3:1069-1075(2001).
  • Q&As
  • Reviews

Q&As (7)

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What structural domains are present in the INSC protein? 10/04/2022

INSC contains a transmembrane domain and an intracellular domain with tyrosine phosphatase activity.

What is the primary function of the INSC protein? 10/02/2022

The primary function of the INSC protein is to regulate insulin secretion in pancreatic beta cells.

In which tissues or cells is INSC predominantly expressed? 02/07/2022

INSC is predominantly expressed in pancreatic islet cells, specifically in beta cells.

How is the expression of INSC regulated at the transcriptional level? 09/09/2021

The expression of INSC is regulated by glucose levels and other factors at the transcriptional level.

Is there any association between INSC and human diseases? 01/18/2018

Mutations in the INSC gene have been associated with autoimmune diabetes and other autoimmune disorders.

Which gene is responsible for encoding the INSC protein? 05/11/2017

The INSC protein is encoded by the INSC gene.

Does INSC play a role in cellular signaling pathways? 05/09/2016

Yes, INSC plays a crucial role in cellular signaling pathways related to insulin secretion.

Customer Reviews (3)

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Reviews
06/22/2020

    Precise immunoprecipitation results consistently reflected the product's quality.

    05/05/2017

      Replicating results underscored the reliability and relevance of the product's effects.

      05/14/2016

        Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

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