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Recombinant Human INSC Protein, GST-tagged

Cat.No. : INSC-5099H
Product Overview : Human INSC full-length ORF ( AAI56333.1, 1 a.a. - 579 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 63.7 kDa
AA Sequence : MRRPPGNGEAASEGPGGWGLWGVQE SRRLCCAGHDRCKQALLQIGINMMA LPGGRHLDSVTLPGQRLHLMQVDSV QRWMEDLKLMTECECMCVLQAKPIS LEEDAQGDLILAGGPGPGDPLQLLL KRGWVISTELRRIGQKLAQDRWARV HSMSVRLTCHARSMVSEYSAVSRNS LKEMGEIEKLLMEKCSELSAVTERC LQVENEHVLKSMKACVSETLSMLGQ HFGQLLELALTREVQALVRKIDASD NIYTTESTTGNLFSLTQEGAPLCRI IAKEGGVVALFKVCRQDSFRCLYPQ ALRTLASICCVEEGVHQLEKVDGVL CLADILTDNSHSEATRAEAAAVVAQ VTSPHLPVTQHLSSFLESMEEIVTA LVKLCQEASSGEVFLLASAALANIT FFDTMACEMLLQLNAIRVLLEACSD KQRVDTPYTRDQIVTILANMSVLEQ CASDIIQENGVQLIMGMLSEKPRSG TPAEVAACERVQQKAAVTLARLSRD PDVAREAVRLSCMSRLIELCRSPSE RNSSDAVLVACLAALRRLAGVCPEG LQDSDFQQLVQPRLVDSFLLCSNME ESFV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : INSC inscuteable homolog (Drosophila) [ Homo sapiens ]
Official Symbol : INSC
Synonyms : INSC; inscuteable homolog (Drosophila); protein inscuteable homolog;
Gene ID : 387755
mRNA Refseq : NM_001031853
Protein Refseq : NP_001027024
MIM : 610668
UniProt ID : Q1MX18

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What structural domains are present in the INSC protein? 10/04/2022

INSC contains a transmembrane domain and an intracellular domain with tyrosine phosphatase activity.

What is the primary function of the INSC protein? 10/02/2022

The primary function of the INSC protein is to regulate insulin secretion in pancreatic beta cells.

In which tissues or cells is INSC predominantly expressed? 02/07/2022

INSC is predominantly expressed in pancreatic islet cells, specifically in beta cells.

How is the expression of INSC regulated at the transcriptional level? 09/09/2021

The expression of INSC is regulated by glucose levels and other factors at the transcriptional level.

Is there any association between INSC and human diseases? 01/18/2018

Mutations in the INSC gene have been associated with autoimmune diabetes and other autoimmune disorders.

Which gene is responsible for encoding the INSC protein? 05/11/2017

The INSC protein is encoded by the INSC gene.

Does INSC play a role in cellular signaling pathways? 05/09/2016

Yes, INSC plays a crucial role in cellular signaling pathways related to insulin secretion.

Customer Reviews (3)

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Reviews
06/22/2020

    Precise immunoprecipitation results consistently reflected the product's quality.

    05/05/2017

      Replicating results underscored the reliability and relevance of the product's effects.

      05/14/2016

        Gel electrophoresis consistently displayed well-defined bands, affirming the product's purity and reliability.

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