ipo7
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  • Official Full Name
  • importin 7
  • Background
  • The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Rans GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
  • Synonyms
  • IPO7; importin 7; RAN binding protein 7 , RANBP7; importin-7; Imp7; FLJ14581; Imp 7; Importin7; IPO 7; IPO7_HUMAN; MGC138673; Ran binding protein 7; Ran-binding protein 7; RANBP 7; RANBP7; OTTHUMP00000230867
Cat.#:IPO7-5076HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IPO7 Protein, GST-tagged
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Cat.#:IPO7-8265MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IPO7 Protein
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Cat.#:IPO7-11148ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IPO7
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Involved Pathway

IPO7 involved in several pathways and played different roles in them. We selected most pathways IPO7 participated on our site, such as PluriNetWork, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PluriNetWork
RCOR2; ZMYM2; XPO4; ZFP143; ZFP57; SMARCC1; IPO7; SALL3; ZSCAN10; KLF5

Protein Function

IPO7 has several biochemical functions, for example, Ran GTPase binding, histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO7 itself. We selected most functions IPO7 had, and list some proteins which have the same functions with IPO7. You can find most of the proteins on our site.
Function
Related Protein
Function Ran GTPase binding
Related Protein IPO13; RANBP1; XPO4; RANBP3; TNPO2; RANBP2; XPO5; KPNB1; XPO1; DPY19L2
Function histone binding
Related Protein PIH1D1; HIST1H4E; SIRT1; H3F3A; HIST1H4C; HIST1H3A; MCM2; DNAJC2; BRD7; CTSL1
Function protein binding
Related Protein RPP38; LRRFIP1; FTCD; HIST3H3; LONP1; CABLES1; PSMC1; KLF2; CITED2; LXN
Function protein transporter activity
Related Protein IPO11; RANBP6; AP1S3B; XPO5; L7RN6; DPY19L2; SOSTDC1B; KPNB3; IPO4; SEC62

Interacting Protein

IPO7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO7.
Ywhae; Ywhah; Tmem173; Iqcb1; Rpgrip1l; Aire

IPO7 Related Articles

Demyanenko, SV; Uzdensky, AB; et al. PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:262-270(2014).
Yu, G; Yan, TH; et al. Ser9 phosphorylation causes cytoplasmic detention of I-2(PP2A)/SET in Alzheimer disease. NEUROBIOLOGY OF AGING 34:1748-1758(2013).