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IPO7

Official Full Name

importin 7
Overview

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Rans GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.
Synonyms

IPO7; importin 7; RAN binding protein 7 , RANBP7; importin-7; Imp7; FLJ14581; Imp 7; Importin7; IPO 7; IPO7_HUMAN; MGC138673; Ran binding protein 7; Ran-binding protein 7; RANBP 7; RANBP7; OTTHUMP00000230867;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IPO7-5076H	Recombinant Human IPO7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	IPO7-2336H	Recombinant Human IPO7 Protein, His-tagged	E.coli	N-His	Met1-Val171	Inquiry
Human	IPO7-3676H	Recombinant Human IPO7 protein, GST-tagged	E.coli	GST	879-1016 aa	$319 / 25ug
Mouse	IPO7-8265M	Recombinant Mouse IPO7 Protein	Mammalian Cell	His		Inquiry
Mouse	IPO7-4582M-B	Recombinant Mouse IPO7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	IPO7-4582M	Recombinant Mouse IPO7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	IPO7-11148Z	Recombinant Zebrafish IPO7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IPO7 Related Articles

IPO7 involved in several pathways and played different roles in them. We selected most pathways IPO7 participated on our site, such as PluriNetWork, which may be useful for your reference. Also, other proteins which involved in the same pathway with IPO7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
PluriNetWork	ZFP143;ZMYM2;SMARCC1;SALL3;ZFP57;RCOR2;XPO4;ZSCAN10;IPO7

IPO7 has several biochemical functions, for example, Ran GTPase binding, histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IPO7 itself. We selected most functions IPO7 had, and list some proteins which have the same functions with IPO7. You can find most of the proteins on our site.

Function	Related Protein
Ran GTPase binding	RANGRF;CSE1L;IPO9;IPO11;KPNB1;BIRC5;IPO4;XPO6;IPO5
histone binding	H3F3B;L3MBTL1;HIST1H4L;HIST1H3A;HIST1H4H;HIST4H4;HJURP;PHF21A;RNF20
protein binding	XCL2;NELL2;SPI1;RAB6B;RNASE1;cgr2b;MAPK14;AUNIP;CEP170L
protein transporter activity	IPO7;RANBP6;XPO6;SEC61G;PPIAL4A;TSNAX;XPO1;KPNA4;AP1B1

IPO7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IPO7 here. Most of them are supplied by our site. Hope this information will be useful for your research of IPO7.

Ywhae; Ywhah; Tmem173; Iqcb1; Rpgrip1l; Aire

Demyanenko, SV; Uzdensky, AB; et al. PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:262-270(2014).

Yu, G; Yan, TH; et al. Ser9 phosphorylation causes cytoplasmic detention of I-2(PP2A)/SET in Alzheimer disease. NEUROBIOLOGY OF AGING 34:1748-1758(2013).