kat8
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  • Official Full Name
  • K(lysine) acetyltransferase 8
  • Background
  • This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Synonyms
  • KAT8; K(lysine) acetyltransferase 8; MOF; hMOF; MYST1; ZC2HC8; histone acetyltransferase KAT8; MYST-1; lysine acetyltransferase 8; histone acetyltransferase MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; probable histone acetyltransferase MYST1; ortholog of Drosophila males absent on the first (MOF);
Cat.#:KAT8-1602HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human K(Lysine) Acetyltransferase 8, GST-tagged
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Cat.#:KAT8-6957HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human KAT8 , GST-tagged
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Cat.#:KAT8-8453MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KAT8 Protein
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Cat.#:KAT8-3158RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KAT8 Protein
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Cat.#:KAT8-12013ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KAT8
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Cat.#:KAT8-1162HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KAT8 cell lysate
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Involved Pathway

KAT8 involved in several pathways and played different roles in them. We selected most pathways KAT8 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
PADI1; JHDM1D; ATXN7L3; C20orf20; ING5B; DNMT3A; TADA3; KDM3B; TADA2B; GATAD2AB
Chromatin organization
BRD1; MSL2; TAF6L; SMARCE1; ASH2L; SMARCA2; KAT6A; KAT7; MBD3; KANSL3
HATs acetylate histones
PHF15; EPC1; ELP4; ING5B; ENY2; MORF4L1; MEAF6; USP22; KANSL2; CSRP2BP
p53 pathway
CSE1L; E4F1; FBXO11; SMYD2; TTC5; PPP1R13L; TRIM28; CSNK1G3; DYRK2; KAT8

Protein Function

KAT8 has several biochemical functions, for example, acetyltransferase activity, enzyme binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT8 itself. We selected most functions KAT8 had, and list some proteins which have the same functions with KAT8. You can find most of the proteins on our site.
Function
Related Protein
Function acetyltransferase activity
Related Protein MBOAT1; LPCAT3; KAT5; HHAT; EP300; KAT2B; AANAT2; ACNAT2; CREBBP; CML5
Function enzyme binding
Related Protein RPA3; SRC; RAD9A; PLCB1; SCNM1-PS; GOT2; MST1R; NOXA1; ITGB3; MAPK8
Function histone acetyltransferase activity
Related Protein HAT1; METTL8; MED24; TAF1; KAT7B; KAT6B; CDYL; HTATIP; TAF1L; CREBBP
Function contributes_to histone acetyltransferase activity (H4-K16 specific)
Related Protein PHF20B; OGT; HCFC1; MCRS1; KAT8; KANSL3; KIAA1267; KANSL2
Function contributes_to histone acetyltransferase activity (H4-K5 specific)
Related Protein KANSL3; MCRS1; PHF20B; KANSL2; KIAA1267; HCFC1; OGT; KAT8
Function contributes_to histone acetyltransferase activity (H4-K8 specific)
Related Protein KAT8; KIAA1267; KANSL3; KANSL2; PHF20B; OGT; MCRS1; HCFC1
Function metal ion binding
Related Protein ADO; ZFP865; CYP2P10; BCL11AB; TRIM35; CYP1D1; ZBTB24; NT5C2; MYO9B; ATP2A3
Function methylated histone binding
Related Protein DPPA3; CBX7; UHRF1; ING2; PHF2; CBX4; PHF8; FAM156A; LRWD1; MSL3
Function protein binding
Related Protein RASSF1; RECQL4; HNRNPF; GFER; GTF3C3; PLIN3; RRP8; SYT7; LBP; ZMYM2
Function transcription factor binding
Related Protein BCOR; TFDP1B; PARK7; RNF19A; POU1F1; JUN; DR1; CEBPG; DRAP1; DIP2A

Interacting Protein

KAT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT8.
KMT2A; TP53; RNF2; WDR5; RBBP5; HHF1; HST2; Kat8; ESRRA; H2AFX; ASH2L