katna1
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  • Official Full Name
  • katanin p60 (ATPase containing) subunit A 1
  • Background
  • Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.
  • Synonyms
  • KATNA1; katanin p60 (ATPase containing) subunit A 1; katanin p60 ATPase-containing subunit A1; EC 3.6.4.3; Katanin p60 ATPase containing subunit A1; Katanin p60 subunit A1; KTNA1_HUMAN; OTTHUMP00000017392; OTTHUMP00000042860; p60 katanin; katanin p60 (ATPase-containing) subunit A 1
Cat.#:KATNA1-7877HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KATNA1 protein, His & T7-tagged
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Cat.#:Katna1-7878MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Katna1 protein, His & T7-tagged
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Cat.#:KATNA1-3159RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KATNA1 Protein
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Cat.#:KATNA1-635CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus KATNA1 Protein, His-tagged
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Cat.#:KATNA1-3440CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KATNA1
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Cat.#:KATNA1-2784ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KATNA1
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Cat.#:KATNA1-888HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KATNA1 cell lysate
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Involved Pathway

KATNA1 involved in several pathways and played different roles in them. We selected most pathways KATNA1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, which may be useful for your reference. Also, other proteins which involved in the same pathway with KATNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lissencephaly gene (LIS1) in neuronal migration and development
DYNLT1; VLDLR; NDEL1; KATNA1; DCX; LRPAP1; NUDC; DAB1; MAP1B

Protein Function

KATNA1 has several biochemical functions, for example, ATP binding, dynein binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KATNA1 itself. We selected most functions KATNA1 had, and list some proteins which have the same functions with KATNA1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKG1A; PFKM; QARS; MAST4; ATP6V1B1; ERBB2; NLK; ORC5; EHD2; MYO5C
Function dynein binding
Related Protein LRRC50; WDR81; DNAAF1; PAFAH1B1B; KATNA1; KATNB1; BICD1; NEFH; SMC3; DCTN6
Function microtubule binding
Related Protein KIF9; KIF5B; BCL2L11; KIF23; PRC1; GAPDH; MAPRE3; DCX; PLK1; KIF14
Function contributes_to microtubule-severing ATPase activity
Related Protein KATNB1; KATNA1
Function protein binding
Related Protein SNRPA; KNG1; ZNF155; NKX2-1; TIMP1; CASP8; MAP1LC3B; PKM; GTF3C4; FNTB
Function protein heterodimerization activity
Related Protein SAE1; BMP2; HIST2H2BE; SYT10; KCNB2; PDSS2; TPD52; SDCBP; SOX8; SPNA1

Interacting Protein

KATNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KATNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KATNA1.
CIAO1; CD40; KATNBL1; SRSF2; AKR7A2; SORBS3; USP1; LATS1; CAPN1; SRPR; MAPT; SOAT1; SRSF3; SPTBN1; SLC30A7; KATNB1; ARHGAP39; KATNBL1; NCKAP5L