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KATNA1

Official Full Name

katanin p60 (ATPase containing) subunit A 1
Overview

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms

KATNA1; katanin p60 (ATPase containing) subunit A 1; katanin p60 ATPase-containing subunit A1; EC 3.6.4.3; Katanin p60 ATPase containing subunit A1; Katanin p60 subunit A1; KTNA1_HUMAN; OTTHUMP00000017392; OTTHUMP00000042860; p60 katanin; katanin p60 (ATPase-containing) subunit A 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Cynomolgus Monkey
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KATNA1-7877H	Recombinant Human KATNA1 protein, His & T7-tagged	E.coli	His/T7	Glu8~Met229 (Accession # O75449)	Inquiry
Human	KATNA1-888HCL	Recombinant Human KATNA1 cell lysate		N/A		Inquiry
Human	KATNA1-2910H	Recombinant Human KATNA1 Protein (Met1-Gly168), His tagged	E.coli	His	Met1-Gly168	Inquiry
Human	KATNA1-2911H	Recombinant Human KATNA1 Protein (Met1-Lys167), N-His tagged	E.coli	N-His	Met1-Lys167	Inquiry
Mouse	Katna1-7878M	Recombinant Mouse Katna1 protein, His & T7-tagged	E.coli	His/T7	Lys260~Cys491 (Accession # Q9WV86)	Inquiry
Rat	KATNA1-3159R	Recombinant Rat KATNA1 Protein	Mammalian Cell	His		Inquiry
Rat	KATNA1-2815R-B	Recombinant Rat KATNA1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KATNA1-2815R	Recombinant Rat KATNA1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	KATNA1-635C	Recombinant Cynomolgus KATNA1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	KATNA1-381C	Recombinant Cynomolgus Monkey KATNA1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	KATNA1-381C-B	Recombinant Cynomolgus Monkey KATNA1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KATNA1-2784Z	Recombinant Zebrafish KATNA1	Mammalian Cell	His		Inquiry
Chicken	KATNA1-3440C	Recombinant Chicken KATNA1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KATNA1 Related Research Area

KATNA1 involved in several pathways and played different roles in them. We selected most pathways KATNA1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, which may be useful for your reference. Also, other proteins which involved in the same pathway with KATNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Lissencephaly gene (LIS1) in neuronal migration and development	NUDC;NDEL1;LRPAP1;KATNA1;MAP1B;VLDLR;DAB1;DCX;DYNLT1

KATNA1 has several biochemical functions, for example, ATP binding, dynein binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KATNA1 itself. We selected most functions KATNA1 had, and list some proteins which have the same functions with KATNA1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	UBE2O;SMC4;RIMKLA;MYH11;TARS;NLRP3;CDK18;DHX57;KIF6
dynein binding	BICD1;SMC3;PAFAH1B1;SNCA;WDR43;DNAAF1;PAFAH1B1A;LRRC50;DCTN6
microtubule binding	FAM154A;PPP5C;NDEL1A;KIF23;PLK1;BCL2L11;NME8;CCDC87;GABARAPL1
contributes_to microtubule-severing ATPase activity	KATNA1;KATNB1
protein binding	ZFP57;KIAA0319L;CD160;PIK3R4;NCOA1;PEX1;GSN;SPRR2E;SDHB
protein heterodimerization activity	UBXN6;OSTA;SAE1;PPP1CBL;INHA;H3F3C;GTF2A2;BOKA;NFYBB

KATNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KATNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KATNA1.

CIAO1; CD40; KATNBL1; SRSF2; AKR7A2; SORBS3; USP1; LATS1; CAPN1; SRPR; MAPT; SOAT1; SRSF3; SPTBN1; SLC30A7; KATNB1; ARHGAP39; KATNBL1; NCKAP5L

Microfilament-associated Proteins

Microtubules