kcnk3
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  • Official Full Name
  • potassium channel, subfamily K, member 3
  • Background
  • This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
  • Synonyms
  • KCNK3; potassium channel, subfamily K, member 3; potassium channel subfamily K member 3; K2p3.1; TASK; TASK 1; cardiac potassium channel; two pore K(+) channel KT3.1; two P domain potassium channel; two pore potassium channel KT3.1; TWIK-related acid-sens
Cat.#:KCNK3-8532MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNK3 Protein
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Cat.#:KCNK3-3212RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNK3 Protein
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Involved Pathway

KCNK3 involved in several pathways and played different roles in them. We selected most pathways KCNK3 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aldosterone synthesis and secretion
CAMK1; PLCB3; ADCY1; CYP11A1; AKR1C1; AGTR1; HSD3B6; DDX1; ITPR1; ORAI1

Protein Function

KCNK3 has several biochemical functions, for example, S100 protein binding, ion channel activity, open rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK3 itself. We selected most functions KCNK3 had, and list some proteins which have the same functions with KCNK3. You can find most of the proteins on our site.
Function
Related Protein
Function S100 protein binding
Related Protein AGER; DDX1; AHNAK; FGF1A; ANXA2; S100A1; S100B; ATP2A2; KCNK3; S100A6
Function ion channel activity
Related Protein CLCN6; KCNQ2A; TPC3; GRIK3; CLCNKB; GRIA2A; CHRNA4B; TRPV2; KCNS3B; TRPC4B
Function open rectifier potassium channel activity
Related Protein DDX1; KCNK3A; KCNK3
Function potassium channel activity
Related Protein KCNK10; KCNF1; KCNK9; TMEM38B; KCNK2B; KCNK7; KCNK10B; KCNQ2A; KCNK5B; KCNK5
Function potassium ion leak channel activity
Related Protein KCNK16; KCNK13A; KCNK2B; TMEM175; KCNK4; KCNK5; KCNK1; KCNK3A; KCNK9; KCNK5B
Function protein C-terminus binding
Related Protein CLIC6; RAD51; RABAC1; NEIL1; AP2A1; ERBB2; TOP2B; CEP120; HESX1; TAF13
Function protein heterodimerization activity
Related Protein NOTCH1; ABCG8; H2AFB2; TLX1; DMRT1; HIST1H2AC; HER11; SMAD4; NAE1; ITGB1
Function protein homodimerization activity
Related Protein PVRL3B; NUDT21; ERP29; ASNSD1; MAP3K11; ABP1; AOC3; MASP1; G6PDX; CHEK2