klrc2
Share
  • Official Full Name
  • killer cell lectin-like receptor subfamily C, member 2
  • Background
  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.
  • Synonyms
  • KLRC2; killer cell lectin-like receptor subfamily C, member 2; NKG2-C type II integral membrane protein; CD159c; NKG2 C; NK cell receptor C; NKG2-C-activating NK receptor; CD159 antigen-like family member C; NKG2C; NKG2-C; MGC138244
Cat.#:KLRC2-4914HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLRC2 Protein
+Inquiry
Cat.#:KLRC2-7062HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLRC2 protein, His & T7-tagged
+Inquiry
Cat.#:KLRC2-2436RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KLRC2 Protein, His-tagged
+Inquiry
Cat.#:KLRC2-4895HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KLRC2 293 Cell Lysate
+Inquiry

Involved Pathway

KLRC2 involved in several pathways and played different roles in them. We selected most pathways KLRC2 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
HLA-DQB1; CD4; HLA-DPA1; KLRC4; HLA-DQA2; RFXANK; PSME1; KIR3DL2; CTSS; HLA-DPB1
Natural killer cell mediated cytotoxicity
KRAS; KIR3DL1; GZMB; Raet1c; PRKCA; IFNGR1; ULBP2; PTPN11; Fasl; NFATC2

Protein Function

KLRC2 has several biochemical functions, for example, MHC class I protein complex binding, carbohydrate binding, protein antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC2 itself. We selected most functions KLRC2 had, and list some proteins which have the same functions with KLRC2. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class I protein complex binding
Related Protein KLRC1; KLRD1; KLRC2
Function carbohydrate binding
Related Protein WBSCR17; NPTX2; GALNTL1; CLEC4E; CLEC2D; CD55; ATRNL1; CD302; PRG3; LGALS2A
Function protein antigen binding
Related Protein ITGA4; KLRD1; EP300; H2-AB1; KLRC2
Function protein binding
Related Protein SSU72; NUP133; EDDM3B; CBLN3; OSBPL6; CYTIP; TFR2; TLR3; SDHAF2; LNX1
Function transmembrane signaling receptor activity
Related Protein CALCRLA; CLEC2H; ENG; KIR2DS2; CD72; P2RX6; OR12D3; VIPR1B; DNER; CD3G

Interacting Protein

KLRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC2.
TYROBP; FBP1