LIN7B Protein, lin-7 homolog B


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Official Full Name lin-7 homolog B
Background Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
Synonyms LIN7B; lin-7 homolog B (C. elegans); protein lin-7 homolog B; LIN 7B; MALS 2; VELI2; hLin7B; hVeli2; veli-2; vertebrate lin-7 homolog 2; mammalian lin-seven protein 2; MALS2; LIN-7B; MALS-2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIN7B-386H Recombinant Human lin-7 homolog B (C. elegans), His-tagged E.coli His
    Human LIN7B-4729HCL Recombinant Human LIN7B 293 Cell Lysate HEK293 N/A
    Mouse LIN7B-9118M Recombinant Mouse LIN7B Protein Mammalian Cell His
    Rat LIN7B-3415R Recombinant Rat LIN7B Protein Mammalian Cell His
    Rhesus Macaque LIN7B-2521R Recombinant Rhesus monkey LIN7B Protein, His-tagged Mammalian Cell His
    Chicken LIN7B-2747C Recombinant Chicken LIN7B Mammalian Cell His
    Zebrafish LIN7B-2877Z Recombinant Zebrafish LIN7B Mammalian Cell His

    LIN7B involved in several pathways and played different roles in them. We selected most pathways LIN7B participated on our site, such as Dopamine Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dopamine Neurotransmitter Release Cycle LIN7B; LIN7A; CCDC167; SYN1; UNC13B; PPFIA4; SYN2; PPFIA1; PPFIA2; SYN3
    Neuronal System CPLX1; HAND2; KCNV1; PANX1; CHRNA2; KCNJ1B; CHRNA4; UNC13B; CCDC167; KCNK1A
    Neurotransmitter Release Cycle BZRAP1; SLC6A1B; UNC13B; SLC1A3B; SYN1; SNAP25A; GLS2B; Apba1; RAB3AA; SLC6A1A
    RHO GTPase Effectors LIN7B; WIPF2; KIF14; MKL1B; RANGAP1B; PRC1; ABI1; DIAPH1; ZW10; NUF2
    RHO GTPases Activate Rhotekin and Rhophilins ROPN1; LIN7B; RTKN; RHOC; RHPN1; TAX1BP3; RHPN2
    Signal Transduction TRIM33; ARHGAP25; ROR2; PTPRK; PRDM4; HEBP1; RGS4; FGFBP2; HEYL; GPR132B
    Signaling by Rho GTPases WIPF3; FAM13B; MYO9B; GDI2; ARHGEF16; RHOT1; RTKN; FGD2; ARHGEF17; FGD4
    Transmission across Chemical Synapses BZRAP1; Apba1; CACNG2B; RAB3AA; CACNB4B; PICK1; SLC1A2A; SYN1; GABRR2A; SNAP25A

    LIN7B has several biochemical functions, for example, L27 domain binding, PDZ domain binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN7B itself. We selected most functions LIN7B had, and list some proteins which have the same functions with LIN7B. You can find most of the proteins on our site.

    Function Related Protein
    L27 domain binding LIN7A; LIN7B; LIN7C; DLG1
    PDZ domain binding LPAR1; GNG5; FZD7; EXOC4; ARHGEF16; LIN7B; LNX2; PDZK1; ACCN3; PARK2
    protein domain specific binding ARRB2; ARR3; TACC1; SHC4; ACSL3; CNTROB; VPS11; RARA; TADA3; SLC34A2

    LIN7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN7B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN7B.

    KCNJ4; ABCA1

    Mizuno, M; Matsumoto, A; et al. Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. JOURNAL OF NEUROCHEMISTRY 132:61-69(2015).
    Kultima, K; Jergil, M; et al. Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity. REPRODUCTIVE TOXICOLOGY 30:457-468(2010).

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