lin7b
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  • Official Full Name
  • lin-7 homolog B
  • Background
  • Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
  • Synonyms
  • LIN7B; lin-7 homolog B (C. elegans); protein lin-7 homolog B; LIN 7B; MALS 2; VELI2; hLin7B; hVeli2; veli-2; vertebrate lin-7 homolog 2; mammalian lin-seven protein 2; MALS2; LIN-7B; MALS-2
Cat.#:LIN7B-386HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human lin-7 homolog B (C. elegans), His-tagged
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Cat.#:LIN7B-9118MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LIN7B Protein
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Cat.#:LIN7B-3415RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LIN7B Protein
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Cat.#:LIN7B-2521RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LIN7B Protein, His-tagged
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Cat.#:LIN7B-2747CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LIN7B
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Cat.#:LIN7B-2877ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LIN7B
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Cat.#:LIN7B-4729HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LIN7B 293 Cell Lysate
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Involved Pathway

LIN7B involved in several pathways and played different roles in them. We selected most pathways LIN7B participated on our site, such as Dopamine Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dopamine Neurotransmitter Release Cycle
SYN2; CCDC167; CPLX1; RERG; Apba1; PPFIA1; LIN7C; LIN7B; LIN7A; SYN3
Neuronal System
CCDC167; KCNH1B; GLS2B; KCNN1B; CPLX1; PANX2; KCNB2; KCNN4; KCNK7; KCNH5A
Neurotransmitter Release Cycle
SNAP25A; PPFIA1; SLC1A2B; LIN7C; SYN2; CPLX2L; SLC6A1B; STXBP1A; ARL6IP5A; SYN1
RHO GTPase Effectors
CLIP1; NUF2; ERCC6L; BAIAP2; RHOGA; MIS12; RCC2; NSL1; PMF1; SPDL1
RHO GTPases Activate Rhotekin and Rhophilins
RHPN1; RTKN; LIN7B; TAX1BP3; ROPN1; RHOC; RHPN2
Signal Transduction
AMOTL2B; MKS1; TJP2B; RBP4; TAGAP1; TLE2; IFT172; OPN5; OR56A1; DHRS3
Signaling by Rho GTPases
FMNL2; RHOT2; STARD13; RHOT1B; DEPDC7; PRC1; MKL1; KTN1; ARHGAP36; CIT
Transmission across Chemical Synapses
LIN7C; SLC1A7B; SLC6A11; CAMKK1B; CACNG2B; SLC1A7A; ARL6IP5B; RERG; GABRR2A; SLC18A3A

Protein Function

LIN7B has several biochemical functions, for example, L27 domain binding, PDZ domain binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN7B itself. We selected most functions LIN7B had, and list some proteins which have the same functions with LIN7B. You can find most of the proteins on our site.
Function
Related Protein
Function L27 domain binding
Related Protein LIN7B; LIN7C; LIN7A; DLG1
Function PDZ domain binding
Related Protein ARHGAP29; CRIPT; CCDC88C; GRIA1; LLGL2; Apba1; SNTA1; CIT; GRID2; ACCN3
Function protein domain specific binding
Related Protein ITGA3; WNT1; YWHAE; PRKAR2B; NFASC; TUBB; LAMP1; HSPA5; HIST2H4A; ARFIP2B

Interacting Protein

LIN7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN7B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN7B.
KCNJ4; ABCA1

LIN7B Related Articles

Mizuno, M; Matsumoto, A; et al. Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. JOURNAL OF NEUROCHEMISTRY 132:61-69(2015).
Kultima, K; Jergil, M; et al. Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity. REPRODUCTIVE TOXICOLOGY 30:457-468(2010).