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Official Full Name lipoprotein, Lp(a)
Background Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophage white blood cells and promoted by low-density lipoproteins (plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high density lipoproteins (HDL), (see apoA-1 Milano). It is commonly referred to as a hardening or furring of the arteries. It is caused by the formation of multiple plaques within the arteries.
Synonyms Oxidized Lipoprotein (a); Oxidized Lp (a); Lipoprotein(a) Oxidized-Lp(a); Oxidized Lipoprotein; LPA
    • Species :
    • Human
    • LP
    • Source :
    • E.coli
    • Human plasma
    • LP
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    LP LPA-352L Native Legionella Pneumophila Antigen Protein LP N/A
    Human LPA-7813H Recombinant Human LPA protein, His-tagged E.coli His
    Human LPA-8453H Native Human LPA Human plasma N/A

    LPA involved in several pathways and played different roles in them. We selected most pathways LPA participated on our site, such as LDL-mediated lipid transport, Lipid digestion, mobilization, and transport, Lipoprotein metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    LDL-mediated lipid transport CETP; LPA; APOBB.1; APOF
    Lipid digestion, mobilization, and transport Alb; APOC2; APOA4B.1; CLPS; FABP12; LMF1; APOA1B; APOA4B.2; APOA4A; FABP11A
    Lipoprotein metabolism CETP; APOA5; APOA4B.1; APOBB.1; LPA; APOEB; APOC2; APOA1B; ABCA1; APOA4B.2
    Metabolism DUT; SLC25A1; TYMP; PPP1R2; ACOT9.1; AKR1C21; CPT2; PAOX; PITPNB; SLC25A16
    Metabolism of lipids and lipoproteins ACOT12; SLC27A2; APOA5; AKR1C6; ALOX5B.3; INSIG2; ACSF3; DGAT1B; SLC27A5; ARSD
    amb2 Integrin signaling CYR61; HP; MST1; NIPAL1; LPA; MST1R; ELANE

    LPA has several biochemical functions, for example, apolipoprotein binding, endopeptidase inhibitor activity, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPA itself. We selected most functions LPA had, and list some proteins which have the same functions with LPA. You can find most of the proteins on our site.

    Function Related Protein
    apolipoprotein binding PCSK9; PLG; VLDLR; LPA; LPL; MAPT; LIPC; LRP1; LRP6; CANX
    endopeptidase inhibitor activity CST14B.1; RENBP; SERPINA1A; Hc; UCHL5; C3A.6; C5; STFA1; STFA2; C4A
    fibronectin binding CTSS; CTSL1; IGFBP5A; IGFBP5; LACRT; VEGFA; PLEKHA2; ITGAV; CCDC80; FSTL3
    heparin binding THBS4; PTCH1; COL5A1; APPB; FGFRL1; APLP1; ZFP207; APOB; FGFR2; RPL29
    protein binding ZBTB7A; IFIT3; SPSB4; ITGB4; SPTSSB; MID2; NPHP4; ANG; DGCR8; RPL36AL
    serine-type endopeptidase activity TMPRSS11B; PRSS44; F12; PRSS41; TPSB2; PRSS59.1; KLKB1; TRY; RHBDD3; CTSH

    LPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPA here. Most of them are supplied by our site. Hope this information will be useful for your research of LPA.

    APOH; FN1

    Leblanc, R; Lee, SC; et al. Interaction of platelet-derived autotaxin with tumor integrin alpha(V)beta(3) controls metastasis of breast cancer cells to bone. BLOOD 124:3141-3150(2014).
    Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).

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