• Official Full Name
  • leucine zipper, putative tumor suppressor 1
  • Background
  • This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.
  • Synonyms
  • LZTS1; leucine zipper, putative tumor suppressor 1; F37/Esophageal cancer related gene coding leucine zipper motif; leucine zipper putative tumor suppressor 1; FEZ1; F37; F37/esophageal cancer-related gene-coding leucine-zipper motif; LZTS1_HUMAN; Psdzip70
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LZTS1 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LZTS1 Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LZTS1, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LZTS1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LZTS1 Protein
Source (Host):Species:Human
Product nameRecombinant Human LZTS1 293 Cell Lysate

Protein Function

LZTS1 has several biochemical functions, for example, DNA binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LZTS1 itself. We selected most functions LZTS1 had, and list some proteins which have the same functions with LZTS1. You can find most of the proteins on our site.
Related Protein
Function DNA binding
Related Protein ZNF573; ZNF436; HIST1H3D; TOP1L; ZNF74; TET3; ZNF784; ZNF227; LHX2A; ZNF395
Function protein binding
Related Protein FANCC; SOX2; SPRR3; ID2; KLF15; KLF13; IKZF1; SFRS9; SIRT7; PPP1R7
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU5F3; NFIL3-4; FOXG1C; TCF7L2; TRIM22; ASCL2; ZNF624; FOXD1; FOXG1A; ZNF7

Interacting Protein

LZTS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LZTS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LZTS1.