mad1l1
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  • Official Full Name
  • MAD1 mitotic arrest deficient-like 1 (yeast)
  • Background
  • Mitotic arrest deficient-like 1 (yeast) is also known as MAD1 and MAD1L1. It is part of the MAD1 family which is crucial to development. MAD1 acts as a checkpoint gene during mitotic spindle assembly. During anaphase and telophase MAD1 is located at the spindle mid-zone of the cell, where it prevents anaphase until the chromosome is aligned at the metaphase plate. During metaphase MAD1 is located at the centrosome. MAD1 participates in cell cycle control and tumor suppression. MAD1 functions as a homodimer and interacts with MAD2L1. It is thought that MAD1 recruits to MAD2, which then promotes binding of MAD2 to CDC20.
  • Synonyms
  • MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1 (mitotic arrest deficient, yeast, homolog) like 1; mitotic spindle assembly checkpoint protein MAD1; HsMAD1; MAD1; PIG9; TP53I9; TXBP181; MAD1-like protein 1; tax-binding protein 181; tumor protein p53 inducible protein 9; mitotic checkpoint MAD1 protein homolog; mitotic arrest deficient 1-like protein 1; mitotic-arrest deficient 1, yeast, homolog-like 1
Cat.#:MAD1L1-176HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAD1L1 Protein, MYC/DDK-tagged
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Cat.#:MAD1L1-682HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAD1L1, His-tagged
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Cat.#:MAD1L1-9427MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAD1L1 Protein
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Cat.#:MAD1L1-11153ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAD1L1
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Danese, S; Panes, J; et al. Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases. GASTROENTEROLOGY 147:981-989(2014).
Allocca, M; Fiorino, G; et al. Blockade of lymphocyte trafficking in inflammatory bowel diseases therapy: importance of specificity of endothelial target. EXPERT REVIEW OF CLINICAL IMMUNOLOGY 10:885-895(2014).