mad1l1
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  • Official Full Name
  • MAD1 mitotic arrest deficient-like 1 (yeast)
  • Background
  • Mitotic arrest deficient-like 1 (yeast) is also known as MAD1 and MAD1L1. It is part of the MAD1 family which is crucial to development. MAD1 acts as a checkpoint gene during mitotic spindle assembly. During anaphase and telophase MAD1 is located at the spindle mid-zone of the cell, where it prevents anaphase until the chromosome is aligned at the metaphase plate. During metaphase MAD1 is located at the centrosome. MAD1 participates in cell cycle control and tumor suppression. MAD1 functions as a homodimer and interacts with MAD2L1. It is thought that MAD1 recruits to MAD2, which then promotes binding of MAD2 to CDC20.
  • Synonyms
  • MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1 (mitotic arrest deficient, yeast, homolog) like 1; mitotic spindle assembly checkpoint protein MAD1; HsMAD1; MAD1; PIG9; TP53I9; TXBP181; MAD1-like protein 1; tax-binding protein 181; tumor protein p53 inducible protein 9; mitotic checkpoint MAD1 protein homolog; mitotic arrest deficient 1-like protein 1; mitotic-arrest deficient 1, yeast, homolog-like 1
Cat.#:MAD1L1-176HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAD1L1 Protein, MYC/DDK-tagged
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Cat.#:MAD1L1-682HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAD1L1, His-tagged
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Cat.#:MAD1L1-9427MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAD1L1 Protein
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Cat.#:MAD1L1-11153ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAD1L1
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Involved Pathway

MAD1L1 involved in several pathways and played different roles in them. We selected most pathways MAD1L1 participated on our site, such as Cell cycle, Progesterone-mediated oocyte maturation, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD1L1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
ARF1; NEK9; CSNK2B; PDS5B; MCM3; CDKN1B; NUPL2; DYNC1I2; E2F6; DHFR
Progesterone-mediated oocyte maturation
AKT2L; PIK3CA; ANAPC7; AKT2; CDC26; MAPK12A; CCNA1; FZR1A; PIK3R3A; PLK1
Viral carcinogenesis
HIST1H2BK; TBP; HIST1H2BE; GTF2A1L; MAPK3; TRAF5; HPN; GTF2H2C_2; HIST2H2BE; GTF2H2C

Protein Function

MAD1L1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAD1L1 itself. We selected most functions MAD1L1 had, and list some proteins which have the same functions with MAD1L1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SDC1; PAK1IP1; ASXL1; ADAMTS5; FAM13C; CARTPT; TIMM44; ARL6IP1; GPATCH4; TTC19

Interacting Protein

MAD1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD1L1.
MAD2L1; TPM3; TRIM29

MAD1L1 Related Articles

Danese, S; Panes, J; et al. Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases. GASTROENTEROLOGY 147:981-989(2014).
Allocca, M; Fiorino, G; et al. Blockade of lymphocyte trafficking in inflammatory bowel diseases therapy: importance of specificity of endothelial target. EXPERT REVIEW OF CLINICAL IMMUNOLOGY 10:885-895(2014).