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MAD1L1

Official Full Name

MAD1 mitotic arrest deficient-like 1 (yeast)
Overview

Mitotic arrest deficient-like 1 (yeast) is also known as MAD1 and MAD1L1. It is part of the MAD1 family which is crucial to development. MAD1 acts as a checkpoint gene during mitotic spindle assembly. During anaphase and telophase MAD1 is located at the spindle mid-zone of the cell, where it prevents anaphase until the chromosome is aligned at the metaphase plate. During metaphase MAD1 is located at the centrosome. MAD1 participates in cell cycle control and tumor suppression. MAD1 functions as a homodimer and interacts with MAD2L1. It is thought that MAD1 recruits to MAD2, which then promotes binding of MAD2 to CDC20.
Synonyms

MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1 (mitotic arrest deficient, yeast, homolog) like 1; mitotic spindle assembly checkpoint protein MAD1; HsMAD1; MAD1; PIG9; TP53I9; TXBP181; MAD1-like protein 1; tax-binding protein 181; tumor protein p53 inducible protein 9; mitotic checkpoint MAD1 protein homolog; mitotic arrest deficient 1-like protein 1; mitotic-arrest deficient 1, yeast, homolog-like 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAD1L1-682H	Recombinant Human MAD1L1, His-tagged	E.coli	His	C-term-350aa	$319 / 25ug
Human	MAD1L1-176H	Recombinant Human MAD1L1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	MAD1L1-1704H	Recombinant Human MAD1L1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MAD1L1-5448H	Recombinant Human MAD1L1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	MAD1L1-9427M	Recombinant Mouse MAD1L1 Protein	Mammalian Cell	His		Inquiry
Mouse	MAD1L1-5290M-B	Recombinant Mouse MAD1L1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mad1l1-3894M	Recombinant Mouse Mad1l1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	MAD1L1-5290M	Recombinant Mouse MAD1L1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	MAD1L1-11153Z	Recombinant Zebrafish MAD1L1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MAD1L1 Related Articles
MAD1L1 Related Research Area

MAD1L1 involved in several pathways and played different roles in them. We selected most pathways MAD1L1 participated on our site, such as Cell cycle, Progesterone-mediated oocyte maturation, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD1L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	NCAPD3;DCTN2;ENSA;NEK9;TMEM188;CEP57;MYCA;GINS2;RAD17
Progesterone-mediated oocyte maturation	HSP90AB1;GNAI1;BRAF;ADCY2B;SPDYA;PIK3R1;MAPK1;CCNA1;PRKACG
Viral carcinogenesis	RBPJ;HIST1H4M;PSMC1;HIST1H2BJ;RBL2;PMAIP1;RELA;HDAC11;BAD

MAD1L1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAD1L1 itself. We selected most functions MAD1L1 had, and list some proteins which have the same functions with MAD1L1. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PFDN4;MED18;LAPTM4B;AP5Z1;ACTR3;ADAM15;HNRNPUL1;POLD3;ACAN

MAD1L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD1L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD1L1.

MAD2L1; TPM3; TRIM29

Danese, S; Panes, J; et al. Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases. GASTROENTEROLOGY 147:981-989(2014).

Allocca, M; Fiorino, G; et al. Blockade of lymphocyte trafficking in inflammatory bowel diseases therapy: importance of specificity of endothelial target. EXPERT REVIEW OF CLINICAL IMMUNOLOGY 10:885-895(2014).

Metaphase (Mitotic Spindle) Checkpoints

Apoptosis Transcription Factors and Regulators