mid1
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  • Official Full Name
  • midline 1 (Opitz/BBB syndrome)
  • Background
  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the RING-B box-coiled coil (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined.
  • Synonyms
  • MID1; midline 1 (Opitz/BBB syndrome); midline-1; FXY; OS; RNF59; TRIM18; BBBG 1; BBBG1; Finger on X and Y mouse homolog of; GBBB 1; GBBB1; MID 1; Midin; Midline 1; Midline 1 ring finger; Midline 1 RING finger protein; Midline1; OGS 1; OGS1; OSX; Putative transcription factor XPRF; RING finger protein 59; RNF 59; TRI18; TRI18_HUMAN; TRIM 18; Tripartite motif containing protein 18; Tripartite motif protein TRIM18; Tripartite motif-containing protein 18; XPRF; Zinc finger X and Y; ZNFXY; OTTHUMP00000022896; OTTHUMP00000022898; OTTHUMP00000022899; OTTHUMP00000022900; OTTHUMP00000022901; OTTHUMP00000022902; tripartite
Cat.#:MID1-5328HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MID1 Protein, GST-tagged
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Cat.#:MID1-30200THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MID1
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Cat.#:Mid1-7951MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mid1 protein, His & T7-tagged
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Cat.#:MID1-9832MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MID1 Protein
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Cat.#:MID1-3682RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MID1 Protein
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Cat.#:MID1-5705CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MID1
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Cat.#:MID1-4321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MID1 293 Cell Lysate
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Cat.#:MID1-4322HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MID1 293 Cell Lysate
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Involved Pathway

MID1 involved in several pathways and played different roles in them. We selected most pathways MID1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MID1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
UBE2D1; UBE2Q1; FBXW11A; WWP2; UBOX5; AIRE; PIAS4A; HERC3; UBE2R2; UBE2NB

Protein Function

MID1 has several biochemical functions, for example, identical protein binding, ligase activity, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MID1 itself. We selected most functions MID1 had, and list some proteins which have the same functions with MID1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein SNX33; HAND1; TTC32; GOT2A; DVL1; EPOR; MDM2; LDHB; L3MBTL1; DYRK1A
Function ligase activity
Related Protein ACSL1; MARCH8; SH3RF2; ZNRF1; TNFAIP3; RNF6; TRIM31; HECW1B; HECW1; MYLIPB
Function microtubule binding
Related Protein KIF3CB; VAPB; KATNB1; KIF3B; CNN3; RACGAP1; LRPPRC; DPYSL2B; MTAP1B; APC2
Function phosphoprotein binding
Related Protein TRPV1; MTOR; PAFAH1B1; FKBP4; CBX4; PRKCSH; PIH1D1; GPRIN1; SFN; URI1
Function protein binding
Related Protein CHD2; HELT; GAK; DLGAP4; IKZF1; SH3RF2; RPS28; SCOC; CAB39; CLASP1
Function protein heterodimerization activity
Related Protein HNF1A; TBX15; KATNA1; EFHA1; HIST1H3G; SMC4; BCL2A; H2AFJ; DRD2; TGFB2
Function protein homodimerization activity
Related Protein IL17F; ASMT; BCL2A1; HOMER2; Defa-rs7; SLC14A2; ANXA9; PAFAH1B1; BMP2B; GLIPR2
Function ubiquitin protein ligase binding
Related Protein RALB; CDC34B; FZD6; TMEM189; USP2; AICDA; UBE2O; UBE2G1A; FAF2; MAP1LC3B
Function zinc ion binding
Related Protein ALPP; MYLIPB; MYNN; SEC23A; FTR72; RORCB; UNKL; ESR2B; QPCTLA; RBM10

Interacting Protein

MID1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MID1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MID1.
UBE2E2; UBE2D1; UBE2D3; UBE2E3