• Official Full Name
  • PARK2 co-regulated
  • Background
  • This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinsons disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinsons disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PACRG; PARK2 co-regulated; parkin coregulated gene protein; FLJ32724; Glup; HAK005771; PARK2CRG; Molecular chaperone/chaperonin binding protein; PARK 2 co regulated; PARK 2 coregulated; PARK2 co regulated; PARK2 coregulated; Parkin co regulated gene; Parkin co regulated gene protein; Parkin coregulated gene; RP3 495O10.2; parkin co-regulated gene protein; molecular chaperone/chaperonin-binding protein; RP3-495O10.2
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PACRG Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PACRG
Source (Host):Species:Human
Product nameRecombinant Human PACRG 293 Cell Lysate
Source (Host):Species:Human
Product nameRecombinant Human PACRG 293 Cell Lysate

Protein Function

PACRG has several biochemical functions, for example, G-protein coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PACRG itself. We selected most functions PACRG had, and list some proteins which have the same functions with PACRG. You can find most of the proteins on our site.
Related Protein
Function G-protein coupled receptor binding
Related Protein GNAI2; FYN; GNA15; GNAV1; PYY; USP20; USP33; NPFFL; ADORA1; SAA1
Function Hsp70 protein binding
Related Protein GPR37; TFRC; DNAJC2; FAM119A; L7RN6; C11orf73; PARK2; DNAJB1; DNAJC10; PPEF2
Function Hsp90 protein binding
Related Protein ERBB2; UNC45B; FKBP6; STUB1; AHR; CDC37; PPID; RPS3; USP19; PPEF2
Function actin binding
Related Protein MTSS1LA; SPATA32; XIRP2; HIP1; KLHL33; PTK2; FMN2; SPATA31; MYO19; TNS1
Function alpha-tubulin binding
Related Protein FAM110C; HDAC6; NDEL1; SLC6A2; WASH1; SNCA; NCALD; TRPV4; INO80; PACRG
Function beta-tubulin binding
Function chaperone binding
Related Protein ST13; INS1; AHSA1L; TG; RNF207; STIP1; DNAJC10; DNAJA2; TFRC; SLC25A17
Function heat shock protein binding
Related Protein FKBP5; KCNJ11; DLST; HSPA6; PARK2; HSPA1A; BAX; BCOR; BAK1; FAF1
Function ubiquitin protein ligase binding
Related Protein ANAPC2; PINK1; RB1; UBE2K; WASH1; SLC22A18; CUL1B; ACVR1B; CUL5A; TUBA1B