PACRG
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Official Full Name
PARK2 co-regulated
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Overview
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinsons disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinsons disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PACRG; PARK2 co-regulated; parkin coregulated gene protein; FLJ32724; Glup; HAK005771; PARK2CRG; Molecular chaperone/chaperonin binding protein; PARK 2 co regulated; PARK 2 coregulated; PARK2 co regulated; PARK2 coregulated; Parkin co regulated gene; Parkin co regulated gene protein; Parkin coregulated gene; RP3 495O10.2; parkin co-regulated gene protein; molecular chaperone/chaperonin-binding protein; RP3-495O10.2;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PACRG-3475HCL | Recombinant Human PACRG 293 Cell Lysate | HEK293 | N/A | ||
Human | PACRG-3474HCL | Recombinant Human PACRG 293 Cell Lysate | HEK293 | N/A | ||
Human | PACRG-6267H | Recombinant Human PACRG Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | Pacrg-4646M | Recombinant Mouse Pacrg Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rhesus Macaque | PACRG-3279R | Recombinant Rhesus monkey PACRG Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | PACRG-3097R | Recombinant Rhesus Macaque PACRG Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | PACRG-3097R-B | Recombinant Rhesus Macaque PACRG Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | PACRG-1782Z | Recombinant Zebrafish PACRG | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
PACRG involved in several pathways and played different roles in them. We selected most pathways PACRG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PACRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PACRG has several biochemical functions, for example, G-protein coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PACRG itself. We selected most functions PACRG had, and list some proteins which have the same functions with PACRG. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein coupled receptor binding | HAND2;GPRC5B;DNAJA1;RSPO3;PROK1;S1PR1;GNAI2A;FCN1;UCN2 |
Hsp70 protein binding | BAG6;CDK1;PACRG;PPEF2;TFRC;RNF207;CDKN1B;PPID;ST13 |
Hsp90 protein binding | FKBP6;RPS3;STUB1;NPAS2;EIF2AK3;GBP1;ARNTL;CSNK2A1;PPID |
actin binding | EPB41L3A;MYOT;AVIL;CAPZA2;PFN2L;CORO2B;WASLB;MSNB;NF2B |
alpha-tubulin binding | INO80;FNTA;HDAC6;ARL8B;CAV3;OFD1;ARL8A;SNCA;NCALD |
beta-tubulin binding | SLC6A2;HDAC6;IFT74;TBCD;SIRT2;RANBP10;RACGAP1;B4GALT1;GABARAP |
chaperone binding | SDF2L1;DNAJC10;ATP1A3;VWF;UBL4;DNAJB1;AHSA2;CDC37;TBCC |
heat shock protein binding | DNAJC7;CDC37;GPR37;DMPK;PDXP;BAK1;PACRG;DNAJA3A;HDAC2 |
ubiquitin protein ligase binding | CUL9;UBE2L3;KDM4A;FOXO1;VCP;PACRG;RNF20;WASH;TRAF1 |
PACRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PACRG here. Most of them are supplied by our site. Hope this information will be useful for your research of PACRG.
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