Recombinant Human PACRG Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PACRG-6267H
• Product Overview: PACRG MS Standard C13 and N15-labeled recombinant protein (NP_001073847) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 29.3 kDa
• AA Sequence: MVAEKETLSLNKCPDKMPKRTKLLA QQPLPVHQPHSLVSEGFTVKAMMKN SVVRGPPAAGAFKERPTKPTAFRKF YERGDFPIALEHDSKGNKIAWKVEI EKLDYHHYLPLFFDGLCEMTFPYEF FARQGIHDMLEHGGNKILPVLPQLI IPIKNALNLRNRQVICVTLKVLQHL VVSAEMVGKALVPYYRQILPVLNIF KNMNVNSGDGIDYSQQKRENIGDLI QETLEAFERYGGENAFINIKYVVPT YESCLLNTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PACRG PARK2 co-regulated [ Homo sapiens (human) ]
• Official Symbol: PACRG
• Synonyms: PACRG; PARK2 co-regulated; parkin coregulated gene protein; FLJ32724; Glup; HAK005771; PARK2CRG; parkin co-regulated gene protein; molecular chaperone/chaperonin-binding protein; GLUP; RP3-495O10.2
• Gene ID: 135138
• mRNA Refseq: NM_001080378
• Protein Refseq: NP_001073847
• MIM: 608427
• UniProt ID: Q96M98