pax4
Share
  • Official Full Name
  • paired box 4
  • Background
  • This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PAX4; paired box 4; KPD; MODY9; paired box protein Pax-4; paired box gene 4; paired domain gene 4;
Cat.#:PAX4-29532THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PAX4
+Inquiry
Cat.#:PAX4-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX4 Protein, His-tagged
+Inquiry
Cat.#:PAX4-12393MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAX4 Protein
+Inquiry
Cat.#:PAX4-4283RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAX4 Protein
+Inquiry
Cat.#:PAX4-8070ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAX4
+Inquiry
Cat.#:PAX4-3417HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAX4 293 Cell Lysate
+Inquiry

Involved Pathway

PAX4 involved in several pathways and played different roles in them. We selected most pathways PAX4 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Maturity onset diabetes of the young
HNF1B; NKX6-1; NKX6; MAFA; HES1; FOXA3; MNX1; NEUROD1; HHEX; PAX4

Protein Function

PAX4 has several biochemical functions, for example, DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding, transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX4 itself. We selected most functions PAX4 had, and list some proteins which have the same functions with PAX4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein POLR2H; ZNF80; H2AFVA; SCXB; PBRM1; POLR2EB; ZFP580; SMAD9; HOXD13; HIST2H2BB
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein JUN; BACH1; ZBTB16; ESRRB; RELA; CDX1; NFKB1; TAL1; ARID3B; SFPQ
Function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein PAX4; GZF1; MSC; BACH2; ARX; BACH1; PROP1; ZBTB16

PAX4 Related Articles

Bonnavion, R; Jaafar, R; et al. Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PLOS ONE 8:-(2013).
Lorenzo, PI; Moreno, CMJ; et al. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. HISTOCHEMISTRY AND CELL BIOLOGY 136:595-607(2011).