pik3r4
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 4
  • Background
  • Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.
  • Synonyms
  • PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide 3-kinase regulatory subunit 4; p150; VPS15; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; phosphoinositide 3-kinase adaptor protein; phosphatidylinositol 3-kinase-associ
Cat.#:PIK3R4-1719HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R4, His-tagged
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Cat.#:PIK3R4-12809MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R4 Protein
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Cat.#:PIK3R4-3183HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIK3R4 293 Cell Lysate
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Involved Pathway

PIK3R4 involved in several pathways and played different roles in them. We selected most pathways PIK3R4 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of autophagy
ULK2; Ifna11; INS1; IFNA13; PIK3R4; ATG4A; IFNA2; IFNA21; IFNA12; INS2

Protein Function

PIK3R4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R4 itself. We selected most functions PIK3R4 had, and list some proteins which have the same functions with PIK3R4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX39AA; DHX34; TWF2; PRKCG; SGK2; RTCB; MAP4K6; DNAH5; ERBB3A; HARS
Function protein binding
Related Protein MARCH2; ROCK1; CCT2; RASSF7; TNNT1; ACP1; BNIP3; P4HB; PAAF1; ZNF187
Function protein kinase activity
Related Protein MAP2K2A; STK30; DYRK1A; ACVR1BA; PAK2; GC3; WNK2; STK17B; PDK1; MAPK14B
Function protein serine/threonine kinase activity
Related Protein WNK2; IRAK3; VRK2; PRKACBB; MAPKAPK2; SMOK2B; CSNK1G1; NEK5; NEK3; ADCK4

Interacting Protein

PIK3R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R4.
ATG14; NRBF2; BECN1

PIK3R4 Related Articles

Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).
Feola, A; Cimini, A; et al. The Inhibition of p85 alpha PI3KSer83 Phosphorylation Prevents Cell Proliferation and Invasion in Prostate Cancer Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 114:2114-2119(2013).