PLD1 Protein, phospholipase D1, phosphatidylcholine-specific


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Official Full Name phospholipase D1, phosphatidylcholine-specific
Background Phospholipase D1 catalyzes the hydrolysis of PC to produce phosphatidic acid and choline and is implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May also be involved in the regulation of perinuclear intravesicular membrane traffic. Phospholipase D2 may have a role in signal induced cytoskeletal regulation and/or endocytosis. The mechanisms that regulate phospholipase D2 are not known.
Synonyms Phospholipase D1 and Phospholipase D2; PLD1; phospholipase D1, phosphatidylcholine-specific; phospholipase D1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLD1-1770H Recombinant Human PLD1, GST-tagged E.coli GST
    Human PLD1-27923TH Recombinant Human PLD1, GST-tagged Wheat Germ GST
    Human PLD1-3123HCL Recombinant Human PLD1 293 Cell Lysate HEK293 N/A
    Rat PLD1-4509R Recombinant Rat PLD1 Protein Mammalian Cell His

    PLD1 involved in several pathways and played different roles in them. We selected most pathways PLD1 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism PHOSPHO1; LPCAT1; GPAM; GPAT2; CDS1; ETNK1; PPAP2CB; PCYT1BB; PLA2G1B; PCYT1AA
    Ether lipid metabolism EPT1; PAFAH1B1A; PLD1; PLA2G4B; PLB1; UGT8A; PLA2G6; LPCAT2; PLA2G7; PLA2G2A
    Metabolic pathways ACSL1B; HYAL3; NANP; MAN1A2; AMY2B; IDH3B; GMPPAB; DPYDB; GLDC; UCK2A
    Ras signaling pathway CALML3; FGF10; PTPN11; PIK3R5; RASAL2; Fasl; RRAS; RGL2; FGF12; RRAS2
    cAMP signaling pathway GRIA1; CALM4; PLN; PIK3CG; PDE4C; CREB3L3; MAPK9; PDE3A; HTR6; ATP1A1
    Sphingolipid signaling pathway PPP2R5D; SPTLC3; RAC3; PIK3R3; TP53; PLCB3; AKT2; SGMS1; MAPK12; GNAI1
    Phospholipase D signaling pathway RHEB; RRAS; GRM1; PIK3R5; PIK3R2; PTK2B; PDGFC; GNA12; PIK3CD; SHC3
    Endocytosis VPS26B; HRASA; SH3GLB1B; FOLR2; TFR1A; HLA-B; LDLRAP1; CDC42; EHD1A; PSD
    Fc gamma R-mediated phagocytosis MAPK1; PLD2; VAV2; PAK1; SCIN; FCGR2A; WASL; INPP5D; PLA2G6; LIMK2
    Glutamatergic synapse GRIN2D; GNAI1; PLCB3; PRKACB; SLC17A6; GRM4; GLS2; GRM1; MAPK1; GNG3
    GnRH signaling pathway CALM3; CAMK2G; PLCB2; CALML3; ELK1; PTK2BB; PLA2G4F; ATF4; SRC; MMP14B
    Pathways in cancer FGF16; GNB3; PTCH2; MECOM; TRAF5; PPARG; GSK3B; NRAS; MAP2K1; TRAF3
    Pancreatic cancer RALGDS; PLD1; PIK3CB; RAC2; PIK3R1; RAD51; TGFB3; BCL2L1; MAP2K1; ARHGEF6
    Choline metabolism in cancer DGKD; PIP5K1A; DGKB; AKT1; SLC22A2; DGKE; PCYT1A; MAP2K1; HRAS; SLC22A5

    PLD1 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD1 itself. We selected most functions PLD1 had, and list some proteins which have the same functions with PLD1. You can find most of the proteins on our site.

    Function Related Protein
    N-acylphosphatidylethanolamine-specific phospholipase D activity PLD4; PLD2; PLD3; PLD1; NAPEPLD
    phosphatidylinositol binding PIK3C2G; PLD2; ITPR1; CCDC88A; HIP1R; SNX27A; SEPT12; PIK3C2B; ARHGAP33; ARHGAP32
    phospholipase D activity PLD3; HMOX1; PLD1; PLD2; PLD4; PLD1A; GPLD1
    protein binding NPBWR1; GSTO1; SSX1; ZFYVE9; ACVR1L; CCDC68; CSDE1; PHYHIPL; C17orf59; ZBP1

    PLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD1.

    CFL1; PKN3; prkC; PLCG1; STXBP1

    Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).
    Alexandrescu, S; Tatevian, N; et al. Morphoproteomics provides support for TGF-beta pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 5:503-511(2012).

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