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PLD1

Official Full Name

phospholipase D1, phosphatidylcholine-specific
Overview

Phospholipase D1 catalyzes the hydrolysis of PC to produce phosphatidic acid and choline and is implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May also be involved in the regulation of perinuclear intravesicular membrane traffic. Phospholipase D2 may have a role in signal induced cytoskeletal regulation and/or endocytosis. The mechanisms that regulate phospholipase D2 are not known.
Synonyms

Phospholipase D1 and Phospholipase D2; PLD1; phospholipase D1, phosphatidylcholine-specific; phospholipase D1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLD1-1770H	Recombinant Human PLD1, GST-tagged	E.coli	GST	725-1074aa	$319 / 25ug
Human	PLD1-27923TH	Recombinant Human PLD1, GST-tagged	Wheat Germ	GST		Inquiry
Human	PLD1-3123HCL	Recombinant Human PLD1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PLD1-4932H	Recombinant Human PLD1 Protein (Thr725-Thr1074), N-His tagged	E.coli	N-His	Thr725-Thr1074	Inquiry
Rat	PLD1-4509R	Recombinant Rat PLD1 Protein	Mammalian Cell	His		Inquiry
Rat	PLD1-4169R	Recombinant Rat PLD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PLD1-4169R-B	Recombinant Rat PLD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PLD1 Related Articles
PLD1 Related Research Area

PLD1 involved in several pathways and played different roles in them. We selected most pathways PLD1 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycerophospholipid metabolism	CRLS1;PLA2G1B;ETNK2;AGPAT3;AGPAT9L;LCLAT1;PLD1A;PLA2G4C;PLA2G12B
Ether lipid metabolism	PPAP2D;LPCAT2;PPAP2B;PLA2G4AA;PPAP2C;GAL3ST1A;PLD2;CEPT1;PAFAH1B1B
Metabolic pathways	ATP6V0A1B;COX5A;MINPP1A;FDPS;PLCB3;SAT1A.1;AMACR;PLA2G12B;CSGALNACT1
Ras signaling pathway	HGF;PLA2G4C;FGF3;RAC2;PIK3CG;ABL2;ABL1;KIT;PTPN11
cAMP signaling pathway	ORAI1;CALM2;GRIN2D;GRIN2B;ATP1B3;PPARA;NFKB1;EP300;FOS
Sphingolipid signaling pathway	ASAH1;PLCB1;MS4A2;PIK3R5;PIK3CB;NSMAF;LASS1;SPHK1;GNA12
Phospholipase D signaling pathway	PIP5K1C;TSC1;PDGFC;MAPK3;PDGFRB;ARF6;PIK3CD;LPAR4;PDGFRA
Endocytosis	SMURF1;SMAD3A;CAPZA2;STAMBPA;TGFB1A;SNX6;CYTH4;TGFB3;PLD2
Fc gamma R-mediated phagocytosis	ASAP1;VAV1;PPAP2A;PLD2;PPAP2B;FCGR2A;LYN;AKT2;WAS
Glutamatergic synapse	GRIN2D;PRKCB;GNG13;DLGAP1;GNG7;GRIA2;MAPK3;GNG5;PPP3CC
GnRH signaling pathway	MAPK12;CALM3A;CALM2;RAF1A;CALML3;GNAQ;ADCY1A;PRKACA;EGFRA
Pathways in cancer	LPAR2;PTGER4;STAT5B;CCNE1;RASSF5;CBLB;GNG5;CCNA1;RUNX1T1
Pancreatic cancer	TGFBR1;IKBKG;SMAD3;STAT1;IKBKB;RAC3;MAP2K1;CASP9;ARHGEF6
Choline metabolism in cancer	SLC5A7;RAC2;LYPLA1;PIP5K1C;HIF1A;PLCG1;MAPK3;SOS1;PRKCG

PLD1 has several biochemical functions, for example, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidylinositol binding, phospholipase D activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLD1 itself. We selected most functions PLD1 had, and list some proteins which have the same functions with PLD1. You can find most of the proteins on our site.

Function	Related Protein
N-acylphosphatidylethanolamine-specific phospholipase D activity	PLD4;NAPEPLD;PLD1;PLD3;PLD2
phosphatidylinositol binding	ESYT2;FCHO2;ING2;SNX29;SNX1A;ITPR2;PASK;SNX18B;HIP1RB
phospholipase D activity	PLD2;PLD1A;PLD4;PLD1;GPLD1;PLD3;HMOX1
protein binding	VPS8;PCGF6;HIST1H4G;USH1C;YEATS4;RHOT1;ZNF263;NTN1;EGR1

PLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLD1.

CFL1; PKN3; prkC; PLCG1; STXBP1

Huang, CF; Bruggeman, LA; et al. Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes. EXPERIMENTAL CELL RESEARCH 318:1075-1085(2012).

Alexandrescu, S; Tatevian, N; et al. Morphoproteomics provides support for TGF-beta pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 5:503-511(2012).

Fatty Acid Catabolism

Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway