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RACGAP1

  • Official Full Name

    Rac GTPase activating protein 1

  • Overview

    The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms

    RACGAP1; Rac GTPase activating protein 1; rac GTPase-activating protein 1; MgcRacGAP; protein CYK4 homolg; male germ cell RacGap; GTPase activating protein; CYK4; ID-GAP; HsCYK-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RACGAP1-1191H Recombinant Human RACGAP1 protein, His & GST-tagged E.coli His/GST Met106~Trp539 (Accession # Q9H0H5)
Human RACGAP1-2150H Recombinant Human RACGAP1, GST-tagged E.coli GST 334-632aa
Human RACGAP1-2565HCL Recombinant Human RACGAP1 293 Cell Lysate HEK293 N/A
Human RACGAP1-5834H Recombinant Human RACGAP1 Protein (Met106-Trp539), N-GST tagged E.coli N-GST Met106-Trp539
Human RACGAP1-4699H Recombinant Human RACGAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RACGAP1-1576H Recombinant Human RACGAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse RACGAP1-13860M Recombinant Mouse RACGAP1 Protein Mammalian Cell His
Mouse RACGAP1-7382M Recombinant Mouse RACGAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Racgap1-5346M Recombinant Mouse Racgap1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RACGAP1-7382M-B Recombinant Mouse RACGAP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RACGAP1-3771R Recombinant Rhesus monkey RACGAP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RACGAP1-3588R-B Recombinant Rhesus Macaque RACGAP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RACGAP1-3588R Recombinant Rhesus Macaque RACGAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RACGAP1-10032Z Recombinant Zebrafish RACGAP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RACGAP1 involved in several pathways and played different roles in them. We selected most pathways RACGAP1 participated on our site, such as Adaptive Immune System, Aurora B signaling, Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with RACGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemRNF220;CYBA;CDKN1B;CTSE;THEM4;MAP3K8;GAN;DCTN2;LRR1
Aurora B signalingSGOL1;AURKC;AURKB;CBX5;RACGAP1;KIF2C;CENPA;NPM1;KIF20A
Factors involved in megakaryocyte development and platelet productionLRRC16A;EHD1;CBX5;AKAP1;KIF4A;BA1L;KIF2B;KIF9;HBG1
HemostasisGNA13;CENPE;KIF4A;ABHD12;AKAP1;PROCA;TAE1;SERPINF2B;PRKCHB
Immune SystemLILRB1;GHRB;CLEC2B;UBA5;DEFB121;KLHL21;BTR12;KIF20A;SH3RF1
KinesinsKIF26A;KIF9;KIF15;KIF3C;KIF4;CENPE;KIF20A;KIFAP3;RACGAP1
MHC class II antigen presentationDCTN6;CTSLL;CTSH;KIF22;IFI30;OSBPL1A;ACTR1B;KIF3C;CTS7
RAC1 signaling pathwayNCKAP1;NOXO1;BAIAP2;ABI1;RACGAP1;IQGAP3;ABI2;NOXA1

RACGAP1 has several biochemical functions, for example, GTPase activator activity, alpha-tubulin binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RACGAP1 itself. We selected most functions RACGAP1 had, and list some proteins which have the same functions with RACGAP1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityARHGAP15;ARHGEF1;RGS3A;WNT11;ARHGAP4A;ACAP3B;SRGAP2A;ARHGAP36;SRGAP3
alpha-tubulin bindingDDL-2;FNTA;HDAC6;TRPV4;INO80;PACRG;SPAST;ARL8B;B4GALT1
beta-tubulin bindingSNCA;SERPINB1A;RACGAP1;RGS2;CCT5;GABARAPL1;PEX14;FGF13;CASC1
gamma-tubulin bindingNME2;B9D2;MARK4;CEP57L1;TUBGCP5;TUBGCP2;BLOC1S2;WASH;FEZ1
metal ion bindingCYP2K17;GLI4;ARSB;B4GALT5;ROR2;ITGB1;ZHX3;EBF2;CSRP1A
microtubule bindingNEIL2;WDR43;CEP350;PAFAH1B1A;EML1;KIF15;KIF6;DCX;MAPRE2
phosphatidylinositol-3,4,5-trisphosphate bindingARHGAP9;DAPP1;GAB2;ASAP1;NRGN;ARAP1;FAM21C;AKT1;FERMT2
protein bindingEDF1;GTF2H3;TADA3;ZNF295;ADARB1;CRB3;PRPF31;PROM1;CXCL9
protein kinase bindingMAP2K3;TRAF3;FOXO3;CDKN2B;CDK5R1;SPDYB;TBL2;DPYSL2;DNAJA3

RACGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RACGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RACGAP1.

KIF23; YWHAG; RAB11FIP3

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