rad51c
Share
  • Official Full Name
  • RAD51 homolog C
  • Background
  • This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be;involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two;other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein;in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair.;This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast;tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor;progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have;been identified.
  • Synonyms
  • RAD51C; RAD51 homolog C (S. cerevisiae); RAD51 (S. cerevisiae) homolog C; DNA repair protein RAD51 homolog 3; RAD51L2; R51H3; RAD51-like protein 2; yeast RAD51 homolog 3; RAD51 homolog C, isoform 1; FANCO; BROVCA3; MGC104277
Cat.#:RAD51C-28601THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RAD51C
+Inquiry
Cat.#:RAD51C-680HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51C Protein, His-tagged
+Inquiry
Cat.#:RAD51C-13872MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAD51C Protein
+Inquiry
Cat.#:RAD51C-1607ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAD51C
+Inquiry
Cat.#:RAD51C-2555HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAD51C 293 Cell Lysate
+Inquiry

Involved Pathway

RAD51C involved in several pathways and played different roles in them. We selected most pathways RAD51C participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51C were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Homologous recombination
RAD51B; RAD51L1; SSBP1; RPA3; NBN; MUS81; BLM; POLD2; RAD51L3; SYCP3
Fanconi anemia pathway
HER6; POLI; HER9; USP1; FUZ; PALB2; ERCC4; ZBTB32; FANCC; POLK

Protein Function

RAD51C has several biochemical functions, for example, ATP binding, DNA binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51C itself. We selected most functions RAD51C had, and list some proteins which have the same functions with RAD51C. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TWF1; ABCG2B; DCLK1A; BCR; PFKFB1; NSFA; NLRP3; MYH9; ACTR1A; ABCA4
Function DNA binding
Related Protein PRM3; MYCN; MIER3; LMX1BA; CTCFL; ZNF350; MYPOP; FOXJ1B; NFYB; ZNF596
Function DNA-dependent ATPase activity
Related Protein XRCC2; SMARCA4; IGHMBP2; SMARCAL1; MSH5; RAD51D; CHD6; RAD51L1; XRCC3; RAD51C
Function contributes_to crossover junction endodeoxyribonuclease activity
Related Protein XRCC3; RAD51C; SLX4
Function double-stranded DNA binding
Related Protein RBMS1; DMC1; RAD51L1; TP73; MTERFD2; NTHL1; YBX1; AIM2; TP63; XRCC2
Function contributes_to four-way junction DNA binding
Related Protein RAD51L1; RAD51L3; RAD51B; RAD51D; MSH2; MSH6; XRCC3; RAD51C; XRCC2
Function protein binding
Related Protein HS3ST5; TBRG1; ANKRD32; CDK2AP1; NDUFB9; MAFG; IL1RAPL1; PLAA; CPSF4; MAP4
Function recombinase activity
Related Protein RAD51C; RAD51B; XRCC3; RBPJ; RAD51L3; RAD51; RAD51D; XRCC2; RAD51L1; DMC1
Function single-stranded DNA binding
Related Protein C10orf2; CNBPA; NABP2; SWSAP1; RAD51C; ERCC4; PEO1; SUB1; LUZP4; CDC45

Interacting Protein

RAD51C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51C here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51C.
XRCC3; RAD51B; RAD51D