rel
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  • Official Full Name
  • v-rel reticuloendotheliosis viral oncogene homolog
  • Background
  • NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.
  • Synonyms
  • REL; C-Rel; proto-oncogene c-Rel; OTTHUMP00000159786; OTTHUMP00000201246; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral; oncogene homolog; NFkB, c-Rel subunit
Cat.#:REL-4018CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken REL
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Cat.#:REL-250ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish REL
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Cat.#:REL-2424HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human REL 293 Cell Lysate
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Involved Pathway

REL involved in several pathways and played different roles in them. We selected most pathways REL participated on our site, such as Ras signaling pathway, Transcriptional misregulation in cancer, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with REL were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
ARF6; PLA2G2E; RAPGEF5; PLD1; GAB2; EFNA4; MAP2K1; HTR7; RELA; GNG13
Transcriptional misregulation in cancer
NFKBIZ; ETV4; HIST1H3D; HOXA10; LRP2BP; IGF1; HOXA9; TSPAN7; HIST2H3C2; HIST1H3H
Viral carcinogenesis
DDX3X; EGR3; GTF2A2; UBE3A; PIK3R5; TP53; ATF4; MRPS18B; KAT2B; ATP6V0D1

Protein Function

REL has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REL itself. We selected most functions REL had, and list some proteins which have the same functions with REL. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein JUN; GATA2; RXRB; MED12; H3F3B; BACH1; CDX1; PBX3; MEOX2; CDX2
Function chromatin binding
Related Protein DNMT3A; SKI; ZFP932; PAX3; NFKB2; CDC45; CRX; CIC; C19orf40; ENY2
Function protein binding
Related Protein CYCS; S100A12; LRRK2; ZFAND2B; STX11; SH2D4A; TA; GOLSYN; VCP; BCLAF1
Function transcription factor activity, sequence-specific DNA binding
Related Protein RUNX2A; PLAGL2; PGBD1; ESR2; ZNF615; SCAND2P; GRHL2A; NFIL3-6; RARG; FOXG1C
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein MEOX2; NFE2L2; RELA; TARDBP; REL; FUBP1; NFKB1; HMGA1; NFE2L1; BACH1

Interacting Protein

REL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REL here. Most of them are supplied by our site. Hope this information will be useful for your research of REL.
TTC21A; NECAP1; a8k5h9_human; STRA13; b2r8y4_human; 23500

REL Related Articles

Nichols, P; Li, L; et al. Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions. MABS 7:212-230(2015).
Heise, N; De Silva, NS; et al. Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappa B transcription factor subunits. JOURNAL OF EXPERIMENTAL MEDICINE 211:2103-2118(2014).