sodium channel, voltage-gated, type IV, beta subunit
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
SCN4B; sodium channel, voltage-gated, type IV, beta subunit; LQT10; Navbeta4; sodium channel subunit beta-4;
Pantazis, A; Savalli, N; et al. Functional heterogeneity of the four voltage sensors of a human L-type calcium channel. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:18381-18386(2014).
Xiao, ML; Bosch, MK; et al. FGF14 localization and organization of the axon initial segment. MOLECULAR AND CELLULAR NEUROSCIENCE 56:393-403(2013).