The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO;precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display;isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed;18799455)).
SENP7; SUMO1/sentrin specific peptidase 7; SUMO1/sentrin specific protease 7; sentrin-specific protease 7; SUMO-1-specific protease 2; sentrin/SUMO-specific protease SENP7; KIAA1707; MGC157730
SENP7 has several biochemical functions, for example, cysteine-type peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP7 itself. We selected most functions SENP7 had, and list some proteins which have the same functions with SENP7. You can find most of the proteins on our site.
Function cysteine-type peptidase activity
Related Protein USP2A; CTSL2; CASP5; CAPN12; CTSM; DESI1; DESI2; FAM105B; CASP6L2; USP9X
Function protein binding
Related Protein SHKBP1; DRD1A; WDFY2; RAB27B; RNF111; SMAP2; TEX19.1; CYBA; ADAMTS13; GAB3
SENP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP7.
CBX5; TRIM28; BCL6
SENP7 Related Articles
Romeo, K; Louault, Y; et al. The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin. CELL REPORTS 10:771-782(2015).
Alegre, KO; Reverter, D; et al. Structural insights into the SENP6 Loop1 structure in complex with SUMO2. PROTEIN SCIENCE 23:433-441(2014).